A5101749964- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Beetle Biology and Toxicology Studies
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Flavonoids in Medical Research
- Ferroptosis and cancer prognosis
- Erythrocyte Function and Pathophysiology
- RNA Research and Splicing
- Kruppel-like factors research
- Cancer-related Molecular Pathways
- Protein Kinase Regulation and GTPase Signaling
- Cancer therapeutics and mechanisms
- Natural product bioactivities and synthesis
- Advanced Breast Cancer Therapies
- Infectious Diseases and Mycology
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
Chongqing Medical University
2014-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2023
Shaanxi Provincial People's Hospital
2020
ABSTRACT Chrysin, a naturally occurring flavone, has been shown to inhibit cell proliferation and induce apoptosis in various cancers. However, the effect mechanisms of chrysin on cancer metastasis are still enigmatic. In this study, metastatic triple‐negative breast (TNBC) lines were used evaluate antimetastatic activity chrysin. The results showed that (5, 10 20 μM) significantly suppressed TNBC migration invasion dose‐dependent manner. Human matrix metalloproteinase (MMP) antibody array...
Aberrant activation of Wnt/β-catenin signaling plays an important role in the pathogenesis breast cancer. DACT1 (Dapper/Frodo) has been identified as involved antagonizing through interacting with Dishevelled (Dvl), a central mediator Wnt signaling, whereas its tumorigenesis remains unclear. We examined expression cancer cell lines and primary tumors semiquantitative or quantitative RT-PCR immunochemistry, further evaluated promoter methylation methylation-specific PCR (MSP). also explored...
// Xuedong Yin 1, * , Tingxiu Xiang Junhao Mu 1 Haitao Mao 2 Lili Li Xin Huang Chunhong 3 Yixiao Feng Xinrong Luo Yuxian Wei Weiyan Peng Guosheng Ren Qian Tao Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital Medical University, Chongqing, China Cancer Epigenetics Laboratory, Department Clinical Oncology, State in South China, Sir YK Pao Center for Ka Shing Institute Health Sciences, Chinese University Hong Kong CUHK Shenzhen Research Institute,...
// Qing Shao 1, * , Xinrong Luo 2, Dejuan Yang 1 Can Wang Qiao Cheng 2 Tingxiu Xiang Guosheng Ren Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital Medical University, Chongqing, China Department Endocrine Breast Surgery, These authors have contributed equally to this work Correspondence to: Xiang, email: larissaxiang@163.com Ren, rengs726@126.com Keywords: PLCD1, tumour suppressor, breast cancer, KIF3A, MMP7 Received: December 15, 2016 Accepted:...
Krüppel-associated box-containing zinc finger proteins (KRAP-ZFPs) are well recognized as key regulators of transcription, which play a crucial role in the regulation cell proliferation, differentiation, apoptosis and tumorigenesis. We previously identified KRAP-ZFP protein ZNF545 acting tumor suppressor involved pathogenesis. However, its expression biological function breast cancer remain elusive. In this study, we found that was frequently downregulated estrogen receptor-positive (ER+),...
// Xinrong Luo 1, 2, * , Xin Xiong Qing Shao 1 Tingxiu Xiang Lili Li 3 Xuedong Yin 2 Xia Qian Tao and Guosheng Ren Chongqing Key Laboratory of Molecular Oncology Epigenetics, The First Affiliated Hospital Medical University, Chongqing, China Department Endocrine Breast Surgery, Cancer Epigenetics Laboratory, Clinical Oncology, State in South China, Sir YK Pao Center for Ka Shine Institute Health Sciences, Chinese University Hong Kong CUHK Shenzhen Research Institute, Shatin, These authors...
Dysregulation of the long non-coding RNA prostate androgen regulated transcript 1 (lncRNA PART1) is involved in tumorigenesis various cancers. However, little known about its function and molecular mechanism development lung squamous cell carcinoma (LSCC). In this study, we examined expression PART1 LSCC clinical tissue samples lines, gain- loss-of-function experiments were performed to explore proliferation, invasion migration. We found that was overexpressed both tissues lines. Functional...
Identifying markers for breast cancer is important both diagnosis and the design of treatment strategies. Recent studies have implicated Paired box 5 (PAX5) as a suppressor in various types, where it silenced by hypermethylation. However, determining role PAX5 requires further study, relationship between methylation remains unclear. In this we found that expression was frequently or reduced cell lines well tissues. Restoring cells led to tumor suppression through inhibited proliferation...
Poly(ADP-ribose) polymerase (PARP)-1 may act in an error-prone pathway called alternative end joining (Alt-EJ) for DNA double-strand break (DSB) repair when nonhomologous is defective. We examined the recruitment of PARP-1 to chromatin response radiomimetic agents and effects inhibition on DSB meiotic recombination (MRE)-11-double-strand (RAD50) protein-Nijmegen breakage syndrome (NSB)-1 (MRN) complex Ku70-deficient breast cancer cells. The chromatin-binding affinity was enhanced...
The tumor microenvironment (TME) plays an important role in the development of breast cancer. Due to limitations experimental conditions, molecular mechanism TME cancer has not yet been elucidated. With bioinformatics, study become convenient and reliable.Gene expression clinical feature data were downloaded from Cancer Genome Atlas database Molecular Taxonomy Breast International Consortium database. Immune scores stromal calculated using Estimation Stromal Cells Malignant Tumor Tissues...
Abstract Purpose: Breast cancer is the leading malignant tumor in women worldwide. Since not responding to endocrine therapy and anti-human epidermal growth factor receptor 2 (HER2) therapy, triple-negative breast (TNBC) has highest recurrence rate among all subtypes of cancer. MicroRNAs have been proved be involved progression various tumors. It demonstrated that miR-301a promotes cell proliferation, migration invasion However, functions underlying mechanism TNBC are undefined. Methods:...
Abstract Background: Aberrant methylation of tumor suppressor genes is a common feature breast cancer. Identifying panel methylated that are sensitive and specific for cancer could help to diagnose predict prognosis Methods: We determined the status DACT1, PAX5, PLCD1, ZNF545 TET1 in 32 benign controls, 237 tissue samples 33 paired plasma samples. Results: PAX5 PLCD1 showed exceedingly high rates with percentages 69.2% 54.9%, whereas percentage were 33.8%, 28.7% 18.2% samples, respectively....