A5100383901- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Crystallography and molecular interactions
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Cancer-related gene regulation
- Food composition and properties
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Metabolism and Genetic Disorders
- Plant tissue culture and regeneration
- Birth, Development, and Health
- Endoplasmic Reticulum Stress and Disease
- Plant Gene Expression Analysis
- Metabolism, Diabetes, and Cancer
- Polysaccharides Composition and Applications
- Biochemical Analysis and Sensing Techniques
Tianjin Medical University
2022-2025
First Affiliated Hospital of Zhengzhou University
2018-2025
State Key Laboratory of Plant Genomics
2025
Institute of Genetics and Developmental Biology
2025
Chinese Academy of Sciences
2009-2025
University of South China
2025
Hunan Cancer Hospital
2025
Central South University
2025
Chinese PLA General Hospital
2012-2025
Ningbo University
2024-2025
Accumulating evidence demonstrates that ferroptosis may be important in the pathophysiological process of traumatic brain injury (TBI). As a major hormone pineal gland, melatonin exerts many beneficial effects on TBI, but there is no information regarding after TBI. expected, TBI resulted time-course changes ferroptosis-related molecules expression and iron accumulation ipsilateral cortex. Importantly, we found treating with potently rescued induced mentioned above improved functional...
We present the analysis of evolution tumors in a case hepatocellular carcinoma. This is particularly informative about cancer growth dynamics and underlying driving mutations. sampled nine different sections from three seven more adjacent nontumor tissues. Selected were subjected to exon as well whole-genome sequencing. Putative somatic mutations then individually validated across all 9 tumor 7 sections. Among validated, 24 amino acid changes; addition, 22 large indels/copy number variants...
Introduction Immunoglobulin (Ig) refers to the nomenclature for all antibody proteins produced by B lymphocytes. The genetic locus encoding Ig is critical vertebrate humoral immune responses and diverse repertoires. Despite role of buffaloes as livestock their significance in disease transmission, loci this species have not been thoroughly annotated. This study aimed systematically characterize unique features, providing a foundation understanding buffalo function. Methods genomic assembly...
MicroRNA 370 (miR-370) is located within the DLK1/DIO3 imprinting region on human chromosome 14, which has been identified as a cancer-associated genomic region. However, role of miR-370 in malignances remains controversial. Here, we report that was repressed hepatocellular carcinoma (HCC) tissues and hepatoma cell lines. Using gain-of-function loss-of-function experiments, demonstrated inhibited malignant phenotype HCC cells vitro. Overexpression growth metastasis vivo. Moreover,...
// Qian-Qian Li 1, * , You-Ke Xie Yue Wu 1 Lin-Lin Ying Liu Xiao-Bo Miao Qiu-Zhen Kai-Tai Yao Guang-Hui Xiao Cancer Institute, Southern Medical University, Guangzhou 510515, China These authors have contributed equally to this work Correspondence to: Xiao, email: ghxiaohh@hotmail.com Keywords: sulforaphane, c-MYC, miR-214, cisplatin, lung cancer Received: June 11, 2016 Accepted: December 27, Published: January 05, 2017 ABSTRACT We herein report that sulforaphane (SFN), a potent anti-cancer...
Abstract In type 1 and 2 diabetes mellitus, increased cardiac fibrosis, stiffness associated diastolic dysfunction may be the earliest pathological phenomena in diabetic cardiomyopathy. Endothelial‐mesenchymal transition (EndMT) endothelia cells (ECs) is a critical cellular phenomenon that increases fibroblasts (CFs) fibrosis hearts. The purpose of this paper to explore molecular mechanism miR‐21 regulating EndMT perivascular vivo, hyperglycaemia up‐regulated mRNA level , aggravated collagen...
Abstract Background Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based assays are employed in more and clinical laboratories to quantify steroids. The steroid quantification by LC-MS/MS shows great value screening or diagnosing endocrine disorders; however, the number of functional steroids included methods is still limited. Methods Here, we describe performance validation a 20-steroid plasma panel LC-MS/MS. progestogens (including mineralocorticoids glucocorticoids), androgens...
Abstract SAP05, a secreted effector by the obligate parasitic bacteria phytoplasma, bridges host SPL and GATA transcription factors (TFs) to 26 S proteasome subunit RPN10 for ubiquitination-independent degradation. Here, we report crystal structures of SAP05 in complex with SPL5, GATA18 RPN10, which provide detailed insights into protein-protein interactions involving SAP05. employs two opposing lobes an acidic path hydrophobic contact TFs respectively. Our structures, conjunction...
Brain ischemic preconditioning (IPC) with mild episodes is well known to protect the brain against subsequent challenges. However, underlying mechanisms are poorly understood. Here we demonstrate critical role of master redox transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), in IPC-mediated neuroprotection and blood-brain barrier (BBB) preservation. We report that IPC causes generation endogenous lipid electrophiles, including 4-hydroxy-2-nonenal (4-HNE), which...
In the initiation and maintenance of arrhythmia, inflammatory processes play an important role. IL-2 is a pro-inflammatory factor which associated with morbidity arrhythmias, however, how affects cardiac electrophysiology still unknown. present study, we observed effect by qRT-PCR on transcription ion channel genes including SCN2A, SCN3A, SCN4A, SCN5A, SCN9A, SCN10A, SCN1B, SCN2B, SCN3B, KCNN1, KCNJ5, KCNE1, KCNE2, KCNE3, KCND3, KCNQ1, KCNA5, KCNH2 CACNA1C. Western blot assays...
Gene Ontology (GO) is one of the most popular bioinformatics resources. In past decade, Ontology-based gene semantic similarity has been effectively used to model gene-to-gene interactions in multiple research areas. However, existing approaches rely only on GO annotations and structure, or incorporate local co-functional network. This may lead inaccurate GO-based resulting from incomplete topology structure annotations.We present NETSIM2, a new network-based method that allows researchers...
Inflammatory responses contribute to the pathogenesis of various neurological diseases, and microglia plays an important role in process. Activated can differentiate into pro-inflammatory, tissue-damaging M1 phenotype or anti-inflammatory, tissue-repairing M2 phenotype. Regulating differentiation, hence limiting a harmful response, might help improve prognosis inflammation-related nervous system diseases. The present study aimed 1. observe anti-inflammatory effect lipoxin A4 (LXA4) on...
Amyotrophic lateral sclerosis (ALS) is known as a progressive paralysis disorder characterized by degeneration of upper and lower motor neurons, has an average survival time three to five years. Growing evidence suggested bidirectional link between gut microbiota neurodegeneration. Here we aimed report one female case with ALS, who benefited from washed transplantation (WMT), improved fecal (FMT), through transendoscopic enteral tube during 12-month follow-up. Notedly, the accidental scalp...
The reprogramming of fibroblasts to induced pluripotent stem cells raises the possibility that somatic could be directly reprogrammed cardiac progenitor (CPCs). present study aimed assess highly efficient protein-based approaches reduce or eliminate genetic manipulations generate CPCs for regeneration therapy. A combination QQ-reagent-modified Gata4, Hand2, Mef2c, and Tbx5 three cytokines rapidly efficiently human dermal (HDFs) into CPCs. This process enriched trimethylated histone H3 lysine...
The exposed N-terminal or C-terminal residues of proteins can act, in cognate sequence contexts, as degradation signals (degrons) that are targeted by specific E3 ubiquitin ligases for proteasome-dependent