A5113264269- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Microbial infections and disease research
- Bat Biology and Ecology Studies
- CRISPR and Genetic Engineering
- Vector-borne infectious diseases
- DNA Repair Mechanisms
- Immune Response and Inflammation
- Heat shock proteins research
- Effects of Environmental Stressors on Livestock
Zunyi Medical University
2024-2025
Introduction Immunoglobulin (Ig) refers to the nomenclature for all antibody proteins produced by B lymphocytes. The genetic locus encoding Ig is critical vertebrate humoral immune responses and diverse repertoires. Despite role of buffaloes as livestock their significance in disease transmission, loci this species have not been thoroughly annotated. This study aimed systematically characterize unique features, providing a foundation understanding buffalo function. Methods genomic assembly...
As an essential molecule for Treg cell function, TCR plays a critical role in various immune responses including development, tolerance, and self-antigen recognition. Current research has identified cells both lymphoid non-lymphoid tissues as important maintaining homeostasis preventing autoimmune reactions. However, the pairing types CDR3 characteristics of these are largely unknown. Through innovative analysis scRNA+TCR-seq data, we discovered that 10.1% to 21.4% dual exist mouse tissues....
Abstract At the 3’ end of C2 gene in mammalian TRB locus, a distinct reverse TRBV30 (named TRBV31 mice) has been conserved throughout evolution. In fully annotated locus 14 mammals (including six orders), we observed noteworthy variations localization and quality V30 genes Recombination Signal Sequences (RSSs) trees 13 mammals. Conversely, forward V29 RSSs were generally consistent with species tree their corresponding species. This finding suggested that evolution was not synchronous likely...
Abstract The quality of Recombination signal sequences (RSSs), location, and genetics mammalian V, D, J genes synergistically affect the recombination frequency genes; however, specific regulatory mechanism efficiency have not been elucidated. By taking advantage single-cell RNA-sequencing (scRNA-seq) high-throughput sequencing (HTS) to investigate V(D)J rearrangement characteristics in CDR3 repertoire, we found that distal proximal V (or genes) “to D” gene were involved significantly more...
Objective: The liver plays a dual role in regulating temperature and immune responses. Examining the influence of heat stress (HS) on T cells contributes significantly to understanding intricate interplay between system hepatic tissues under thermal stress. This study focused investigating characteristics T-cell receptor (TCR) β chain CDR3 repertoire bovine samples both HS pairfed (PF) environmental conditions.Methods: Sequencing data from six sourced GEO database underwent annotation....