A5065509019- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Diabetes Treatment and Management
- Obesity, Physical Activity, Diet
- Inflammatory Bowel Disease
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- Immunodeficiency and Autoimmune Disorders
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Mercury impact and mitigation studies
- Sarcoma Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Diabetes Management and Education
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Consumer Attitudes and Food Labeling
- Gout, Hyperuricemia, Uric Acid
- Microscopic Colitis
Guangdong Provincial People's Hospital
2017-2025
Peking University
2015-2025
First Hospital of Jilin University
2014-2025
Jilin University
2014-2025
Children's Hospital of Philadelphia
2021-2025
University of Pennsylvania
2021-2025
Ganzhou People's Hospital
2018-2024
Nova Southeastern University
2024
Southampton Hospital
2024
Guangdong Academy of Medical Sciences
2024
By mimicking the RIBE machinery, we provided an indirect radiotherapy approach based on RT-MP for eradication of MPE in mice.
Background: Tumor associated macrophages (TAMs) have strong plasticity and if reprogrammed, can clear tumor cells regulate the adaptive immune system for cancer immunotherapy. Deubiquitinating enzymes (DUBs), which remove ubiquitin (Ub) from Ub-modified substrates, been with oncogenic metabolism but are not well-known regulating TAMs repolarization. Methods: The expression of DUB related genes in (MΦs) was detected by reverse transcription-PCR. Flow cytometry immunofluorescence were used to...
Simultaneously targeted treatment of tumor cells and their surrounding growth-supporting immune is a promising strategy to reshape immunosuppressive microenvironment (TME) potentiate host innate adaptive antitumor responses.Methods: We designed series melittin-(RADA)n hybrid peptide sequences with varying self-assembling motifs RADA screened out melittin-(RADA)6 that has an optimal gel-formation ability in vitro activity.Results: The formed (MR52) hydrogel scaffold could be loaded specific...
Background: Since T cell exclusion contributes to tumor immune evasion and immunotherapy resistance, how improve infiltration into solid tumors becomes an urgent challenge. Methods: We employed deep learning profile the microenvironment (TIME) in triple negative breast cancer (TNBC) samples from TCGA datasets noticed that fibroblast growth factor receptor (FGFR) signaling pathways were enriched immune-excluded phenotype of TNBC. Erdafitinib, a selective FGFR inhibitor, was then used...
ABSTRACT Chrysin, a naturally occurring flavone, has been shown to inhibit cell proliferation and induce apoptosis in various cancers. However, the effect mechanisms of chrysin on cancer metastasis are still enigmatic. In this study, metastatic triple‐negative breast (TNBC) lines were used evaluate antimetastatic activity chrysin. The results showed that (5, 10 20 μM) significantly suppressed TNBC migration invasion dose‐dependent manner. Human matrix metalloproteinase (MMP) antibody array...
Background: The number of patients with type 2 diabetes (T2D) is increasing. Medication treatment great importance to stabilize blood glucose. Previous studies have reported that neuroticism, self-efficacy, and social support are factors associated medication adherence, but few fully investigated the mechanisms between these adherence in T2D. Purpose: To explore prevalence Methods: A cross-sectional study consisting 483 T2D was conducted from July December 2020. Questionnaires containing...
Abstract Brain metastases (BRM) are common in advanced lung cancer. However, their treatment is challenging due to the blood‐brain barrier (BBB) and immunosuppressive tumor microenvironment (ITME). Microparticles (MPs), a type of extracellular vesicle, can serve as biocompatible drug delivery vehicles that be further modulated with genetic engineering techniques. MPs prepared from cells induced different insults compared it found radiation‐treated cell‐released microparticles (RMPs) achieve...
Abstract Background To describe and analyze the patterns of adverse events associated with dipeptidyl peptidase-4 inhibitors (DPP-4is) (sitagliptin, saxagliptin, linagliptin, vildagliptin, alogliptin) from FDA Adverse Event Reporting System (FAERS) to highlight areas safety concerns. Methods spontaneously submitted FAERS between 2004 Q1 2019 Q2 were included. The online tool OpenVigil 2.1 was used query database. research relied on definitions preferred terms (PTs) specified by Medical...
Fear of childbirth (FOC) occurs before, during and after pregnancy is harmful to both the pregnant woman fetus. Identifying prevalence predictors FOC can help us generate strategies for alleviating women's FOC.A cross-sectional study was conducted among a convenience sample 646 women receiving antenatal care at subordinate hospital university in China. Data were collected using basic information form, Childbirth Attitude Questionnaire, Self-Efficacy Inventory, 10-item Connor-Davidson...
Abstract Our purpose was to perform a meta‐analysis evaluate the effect of Low‐level laser therapy (LLLT) on diabetic foot ulcers (DFUs). The PubMed, Cochrane, Embase, Web Science, Chinese BioMedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), VIP and Wanfang databases were searched systematically up August 27, 2020. Studies that met inclusion criteria included in analysis. A total 13 randomised controlled trials (RCTs) 413 patients analysed. Compared with...
Abstract Background Phthalates, widely used as chemical additives, are often found mixtures in the environment. However, combined impact of phthalate exposure on sarcopenia remains unclear. Objective This study aimed to investigate relationships between phthalates and adults. Methods We analyzed data from 3,536 participants National Health Nutrition Examination Survey (NHANES) conducted 2011 2018. Multivariable logistic regression, restricted cubic splines (RCSs), weighted quantile sum...
Abstract Objectives Real‐world data on ustekinumab for the treatment of pediatric Crohn's disease (CD) are limited. This study sought to evaluate effectiveness, long‐term durability, and safety in children with CD. Methods A retrospective longitudinal cohort CD treated from two large centers between 2015 2020 was performed. The primary outcome frequency steroid‐free clinical remission at 1 year. Secondary outcomes included time remission, biochemical drug escalation discontinuation, serum...
We evaluated the clinical and laboratory features of decreased serum calcium (albumin corrected or uncorrected) compared to non-hypocalcemia in SLE patients. Exploring value assessing activity prognosis disease. Retrospective analysis comparison data obtained during treatment period patients from 2018 2023. Both quantity titer anti-dsDNA antibodiesin with hypocalcemia were significantly increased, peripheral leucocytes, platelets, complement C3 C4 reduced, while urinary cast 24 h urine...
With the rapid spread of novel coronavirus (COVID-19), a sustained global pandemic has emerged. Globally, cumulative death toll is in millions. The rising number COVID-19 infections and deaths severely impacted lives people worldwide, healthcare systems, economic development. We conducted retrospective analysis characteristics patients. This includes clinical features upon initial hospital admission, relevant laboratory test results, imaging findings. aimed to identify risk factors for...
The present cross-sectional survey was performed to assess the prevalence and factors associated with fear of hypoglycemia (FoH) in hospitalized patients type 2 diabetes (T2D). Between July December 2020, 494 T2D were evaluated via structured questionnaires containing sociodemographic information, clinical Fear Hypoglycemia-15 scale (FH-15). Patients divided into FoH non-FoH groups according FH-15 score. Univariate multivariate logistic regression analyses determine FoH. Variables P values <...
Abstract Hyperplasia suppressor gene (HSG), also called human mitofusin 2, is a novel that markedly suppresses the cell proliferation of hyperproliferative vascular smooth muscle cells from spontaneously hypertensive rat arteries. This encodes mitochondrial membrane protein participates in fusion and contributes to maintenance operation network. In this report, we showed an adenovirus vector encoding HSG (Ad5-hHSG) had antitumor activity wide range cancer lines. We further focused on lung...
Background: Hyperuricemia (HUA) is a major public health issue with high prevalence worldwide. Wuling San (WLS) an effective treatment for HUA. However, the active compounds and related mechanism are unclear. In this study, we aimed to explore underlying pharmacological mechanisms of WLS against Methods: First, network pharmacology approach was used detect WLS, potential targets signaling pathways involved in HUA were predicted. Then, molecular docking strategy predict affinity between key...