Abstract Adverse event reports submitted to the US Food and Drug Administration (FDA) were analyzed map safety profile of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). We conducted a disproportionality analysis adverse events (AEs) EGFR-TKIs (gefitinib, erlotinib, afatinib, osimertinib) by data mining using FDA reporting system (AERS) database, calculating odds ratios (ROR) with 95% confidence intervals. The AERS database contained 27,123 EGFR-TKI-associated AERs...

A recent large epidemiological study found fluoroquinolone use is associated with an increased risk of aortic aneurysm or dissection. We aimed to examine (ciprofloxacin, levofloxacin and moxifloxacin) dissection through data mining the US Food Drug Administration Adverse Event Reporting System (FAERS).Reports FAERS from 1 January 2004 31 December 2016 were analysed. Pharmacovigilance tools used for quantitative detection signals that is, drug-associated adverse events, including reporting...

In the Chinese coronavirus epicenter, Wuhan, 16 cabin hospitals were built to admit patients with confirmed infection (COVID-19). These serve role of effectively quarantine and treat mild cases infected COVID-19. Each hospital has pharmacists provide services pharmaceutical care patients. Pharmacists also assistance through remote internet platforms across China. this commentary, we describe pharmacy at share our experiences international community.

Abstract Background To describe and analyze the patterns of adverse events associated with dipeptidyl peptidase-4 inhibitors (DPP-4is) (sitagliptin, saxagliptin, linagliptin, vildagliptin, alogliptin) from FDA Adverse Event Reporting System (FAERS) to highlight areas safety concerns. Methods spontaneously submitted FAERS between 2004 Q1 2019 Q2 were included. The online tool OpenVigil 2.1 was used query database. research relied on definitions preferred terms (PTs) specified by Medical...

Because of contradictory evidence from clinical trials, the association between angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer needs further evaluation. As such, current study is to assess disproportionate reporting primary malignant among reports for ACEIs submitted FDA adverse event system utilizing a pharmacovigilance approach. We conducted disproportionality analysis events associated with 10 by calculating reported odds ratios (ROR) information component (IC) 95%...

Previous studies have demonstrated that medication adherence has an impact on health-related quality of life (HRQoL). However, other medication-related factors may influence HRQoL not been extensively studied, especially based the Medication-Risk Questionnaire (MRQ), and such are mostly done in Western countries. Our objective was to explore risk associated with among community-dwelling elderly chronic diseases mainland China, regarding MRQ.The study conducted a community health service...

Background Middle mediastinal masses comprise a wide variety of tumors but may also reflect lymphadenopathy, and thus remain an interesting diagnostic challenge. We performed positron emission tomography (PET) in order to evaluate the ability PET predict malignancy these tumors. compared histologic findings, videomediastinoscopy, computed (CT), PET-CT patients with disease. Methods Thirty-two were evaluated CT, videomediastionoscopy, all studies within four weeks each patient. 11C-choline as...

Capecitabine has been reported to be associated with severe gastrointestinal (GI) adverse drug reactions (gastrointestinal ulceration, haemorrhage, and obstruction). However, statistical correlations have not demonstrated, specific GI reactions, such as obstruction, are listed on its label.

There is a lack of data on drug-related problems (DRPs) among elderly patients from surgical departments. The current study aimed at identifying and categorizing types DRPs assessing the severities DRPs. Medication orders for hospitalized aged ≥65 years six surgery departments were reviewed to determine over 6 months in tertiary teaching hospital Chongqing, China. classified based Pharmaceutical Care Network Europe classification V8.02. severity ratings assessed using National Coordinating...

Backgrounds: Proteasome inhibitors (PI) cause toxic peripheral neuropathy (PN), which is one of the dose-limiting adverse events these treatments. Recent preclinical studies find that factor Xa inhibitor (FXaI), rivaroxaban, promotes PN in animals receiving oxaliplatin. Cancer patients can receive combined therapy PI and FXaI. This study aimed to identify characterize interaction signals for concomitant use FXaI resulting PN. Methods: Reports from United States FDA Adverse Event Reporting...

There is no consensus information on infections associated with nonbenzodiazepines. Knowledge about related to newly marketed hypnotics (orexin receptor antagonists and melatonin agonists) scarce. The study aimed detect infection signals for nonbenzodiazepines, orexin antagonists, agonists by analyzing data from the U.S. Food & Drug Administration adverse event reporting system.A disproportionality analysis was performed quantitatively calculating odds ratio 95% confidence interval. Data...

Multiple engineering projects have confirmed that hydraulic machinery operating in sediment-laden rivers suffers from sediment abrasion. Guide vanes are among the most severely worn flow-passing components and long been a key research focus machinery. This study conducted wear tests using asymmetric incoming flow with 10° impact angle an NACA0012 aluminum alloy airfoil as object. The development of was analyzed, revealing it primarily occurs at airfoil’s leading edge progresses through three...

Abstract The prognostic utility of presentation or "peak" high-sensitivity troponin T (hsTnT) levels following ST-segment elevation myocardial infarction (STEMI) has been previously reported, but hsTnT, unlike other bio-markers myocyte damage, have a 2nd ‘plateau-phase’ release which lasts over week. We reported correlations between plateau-phase hsTnT levels, and cardiac MRI determined infarct size, though whether these are more highly associated with late mortality than (or highest) needs...