A5100418953- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Bioactive Natural Diterpenoids Research
- Medicinal Plant Pharmacodynamics Research
- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
- Traditional Chinese Medicine Studies
- Analytical chemistry methods development
- Medical Research and Treatments
- Angiogenesis and VEGF in Cancer
- Drug-Induced Hepatotoxicity and Protection
- Biological Activity of Diterpenoids and Biflavonoids
- Analytical Chemistry and Chromatography
- Healthcare and Venom Research
- Neurological Disease Mechanisms and Treatments
- Phytochemical compounds biological activities
- Analytical Methods in Pharmaceuticals
- Pharmacy and Medical Practices
- Food Quality and Safety Studies
- Pharmacogenetics and Drug Metabolism
Bethune International Peace Hospital
2025
Hebei Normal University of Science and Technology
2023-2025
Hubei University of Arts and Science
2025
Nanjing University of Chinese Medicine
2015-2024
Third Hospital of Hebei Medical University
2017-2024
Hebei Medical University
2017-2024
Sichuan University
2023-2024
Yinchuan First People's Hospital
2008-2024
Sichuan Agricultural University
2011-2024
Huazhong University of Science and Technology
2016-2024
In an effort to elucidate the molecular mechanisms underlying cerebral vascular alteration after stroke, authors measured spatial and temporal profiles of blood–brain barrier (BBB) leakage, angiogenesis, endothelial growth factor (VEGF), associated receptors, angiopoietins receptors embolic stroke in rat. Two four hours onset ischemia, VEGF mRNA increased, whereas angiopoietin 1 (Ang 1) decreased. Three-dimensional immunofluorescent analysis revealed coincidence between increases...
Baicalein is the main active compound of Scutellaria baicalensis Georgi, a medicinal herb with multiple pharmacological activities, including broad anti-virus effects. In this paper, preclinical study baicalein on treatment COVID-19 was performed. Results showed that inhibited cell damage induced by SARS-CoV-2 and improved morphology Vero E6 cells at concentration 0.1 μM above. The effective could be reached after oral administration 200 mg/kg crystal form β in rats. Furthermore,...
We investigated the effects of NO on angiogenesis and synthesis vascular endothelial growth factor (VEGF) in a model focal embolic cerebral ischemia rat. Compared with control rats, systemic administration an donor, DETANONOate , to rats 24 hours after stroke significantly enlarged perimeters increased number proliferated cells numbers newly generated vessels ischemic boundary regions, as evaluated by 3-dimensional laser scanning confocal microscopy. Treatment VEGF levels regions measured...
Chronic kidney disease (CKD) results in significant dyslipidemia and profound changes lipid lipoprotein metabolism. The associated dyslipidemia, turn, contributes to progression of CKD its cardiovascular complications. To gain an in-depth insight into the disorders metabolism advanced CKD, we applied UPLC-HDMS-based lipidomics measure serum metabolites 180 patients with 120 age-matched healthy controls. We found increases levels total free fatty acids, glycerolipids, glycerophospholipids...
Nano metal oxides are becoming widely used in industrial, commercial and personal products (semiconductors, optics, solar cells, catalysts, paints, cosmetics, sun-cream lotions, etc.). However, the relationship of surface features (exposed planes, defects chemical functionalities) with physiochemical properties is not well studied primarily due to lack a simple technique for their characterization. In this study, solid state 31P MAS NMR map surfaces on various ZnO samples assistance...
Vacuolar H(+)-ATPases (V-ATPases) are essential for acidification of intracellular compartments and proton secretion from the plasma membrane in kidney epithelial cells osteoclasts. The cellular proteins that regulate V-ATPases remain largely unknown. A screen bind V-ATPase E subunit using yeast two-hybrid assay identified cDNA clone coded aldolase, an enzyme glycolytic pathway. interaction between aldolase was confirmed vitro by precipitation assays subunit-glutathione S-transferase...
Tanshinone IIA is an active component of a traditional Chinese medicine based on Salvia miltiorrhiza, which reduces sudden cardiac death by suppressing ischaemic arrhythmias. However, the mechanisms underlying anti-arrhythmic effects remain unclear.A model myocardial infarction (MI) in rats ligating left anterior descending coronary artery was used. or quinidine given daily, before (7 days) and after (3 months) MI; electrical activity monitored ECG recording. Whole-cell patch-clamp...