A5001251532- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Fungal and yeast genetics research
- Immune Response and Inflammation
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- RNA modifications and cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Peptidase Inhibition and Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Neurotoxicity Research
- Cardiac Fibrosis and Remodeling
- Fermentation and Sensory Analysis
- Yeasts and Rust Fungi Studies
- Thermal Regulation in Medicine
- Immune responses and vaccinations
- Polymer-Based Agricultural Enhancements
- Biomarkers in Disease Mechanisms
- Cytokine Signaling Pathways and Interactions
- Galectins and Cancer Biology
- Plant responses to water stress
Universidad de La Laguna
1999-2023
Harvard University
2009-2023
Boston University
2016
Massachusetts General Hospital
2016
University of Chicago
2011
Harvard University Press
2008-2009
Hospital Universitario Nuestra Señora de Candelaria
2006-2007
University of Groningen
2004
Consejo Superior de Investigaciones Científicas
1999
Patients with chronic obstructive pulmonary disease (COPD) have increased lymphoid follicle (LF) counts. B cell-activating factor of tumor necrosis family (BAFF) regulates cells in health, but its role COPD pathogenesis is unclear.To determine whether BAFF expression LFs correlates severity, LF size or number, and/or readouts B-cell function LFs.We correlated immunostaining lung explants biopsies from nonsmoking control subjects (NSC), smokers without (SC), and patients the number LFs,...
Hyperbilirubinaemia is a common complication of sepsis. Elevated bilirubin may induce inflammation and apoptosis. It was hypothesised that increased serum on Intensive Care Unit (ICU) admission contributes to sepsis-related acute respiratory distress syndrome (ARDS).Serum ICU measured in 1006 patients with Serial analysed prospectively sepsis who had ARDS for period 28 days. The effects clinical factors variants the UGT1A1 gene levels were determined. Outcomes risk mortality.During 60-day...
Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of susceptibility factors remains incomplete.
Introduction Common variants in genes related to inflammation, innate immunity, epithelial cell function, and angiogenesis have been reported be associated with risks for Acute Lung Injury (ALI) outcomes. We tested whether previously-reported associations can validated an independent cohort at risk ALI. Methods identified 37 genetic 27 previously ALI prepared allelic discrimination assays 12 SNPs from 11 MAF>0.05 genotyped these Caucasian subjects a of critically ill patients meeting...
MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagnostic biomarkers for human ARDS.This nested case-control study (N = 530) examined a cohort ARDS patients critically ill at-risk controls. Whole miRNA profiles logistic regression analyses identified correlated with ARDS. Stratification analysis also selected markers their role sepsis...
There is an urgent need to improve lung cancer outcome by identifying and validating markers of risk. We previously reported that the cytokinesis-blocked micronucleus assay (CBMN) a strong predictor Here, we validate our findings in independent external population test discriminatory power improvement Spitz risk prediction model upon extension with this biomarker.A total 1,506 participants were stratified into set 995 (527 cases/468 controls) from MD Anderson Cancer Center (Houston, TX)...
Rationale: Platelets are believed to contribute acute respiratory distress syndrome (ARDS) pathogenesis through inflammatory coagulation pathways. We recently reported that leucine-rich repeat–containing 16A (LRRC16A) modulates baseline platelet counts mediate ARDS risk.Objectives: To examine the role of LRRC16A in survival and its mediating effect platelets.Methods: A total 414 cases with from intensive care units (ICUs) were recruited who had exome-wide genotyping data, detailed counts,...
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
Sepsis is the most common cause of acute lung injury (ALI), leading to organ dysfunction and death in critically ill patients. Previous studies associated variants interleukin-1 receptor-associated kinase genes (IRAKs) with differential immune responses pathogens outcomes during sepsis, revealed that increased expression levels IRAK3 gene were correlated poor sepsis. Here we explored whether susceptibility to, of, severe After our discovery polymorphism, genotyped a subset seven...
Section:ChooseTop of pageAbstract <<Material and MethodsResultsDiscussionReferencesCITING ARTICLES
Abstract Ynt1 is the only high‐affinity nitrate uptake system in Hansenula polymorpha. Nitrate was directly correlated with levels and shown to be independent of reductase (NR) activity levels. failed transport chlorate and, as a result, strains lacking YNT1 were sensitive chlorate, wild‐type. Nitrite wild‐type strain partially inhibited by ‐disrupted which, turn, nitrite not nitrate. It concluded that takes place two different systems: nitrite‐specific transporter(s). The induced nitrate;...
The role of nitrate reductase (NR) in the regulation assimilation pathway was evaluated yeast Hansenula polymorpha. Posttranscriptional NR response to reduced nitrogen sources and effect a heterologous on transcriptional nitrate-assimilatory gene expression examined. strain bearing YNR1 (nitrate gene) under control methanol-induced MOX (methanol oxidase) promoter showed that is active presence sources. In cells incubated with glutamine plus nitrate, rapamycin abolished catabolite repression,...
To characterize predictors of insulin-like growth factor-1 and factor-binding protein-3 in acute critical illness with the hypothesis that factors associated will more strongly predict circulating than chronic clinical or genetic factors.
Previous evidence based on the experience of our laboratory showed that one-step gene disruption in yeast Hansenula polymorpha is not straightforward. A systematic study several factors which could affect frequency was carried out. We found more critical factor affecting H. length target region flanking marker gene. Target regions about 1 kb were necessary to obtain a 50%. However, marker, either homologous or heterologous, locus and strain examined did significantly disruption; highest...
Epidermal growth factor (EGF) is involved in alveolar epithelial repair, lung fluid clearance and inflammation, regulated by sex hormones. An unmatched, nested case–control study was conducted to evaluate the associations of EGF variants with acute respiratory distress syndrome (ARDS) role on between ARDS. Patients ARDS risk factors upon intensive care unit admission were enrolled. Cases 416 Caucasians who developed controls 1,052 did not develop followed for clinical outcomes 60-day...
Objectives: Acute respiratory distress syndrome is characterized by an overly exuberant inflammatory state in the lung. Specialized proresolving mediators are endogenous agonists for resolution of lung inflammation and injury health, yet their association with acute severity outcomes remains to be defined. In current study, we investigate associations between plasma levels specialized mortality. Design: Translational pilot study nested within a large prospective cohort patients risk factors...
Migraineurs have an interictal sympathetic nervous system (SNS) hypofunctionality and hypersensitivity to adrenergic amines. The GNAS1 T393C polymorphism has been associated with a distinct SNS sensitivity in healthy subjects. We tested variant two independent sets of In the case-control subset, 365 migraine patients [194 aura (MA)] vs. 347 controls were studied. A significant excess CC genotype was found migraneurs (31.2%) as opposed (20.2%; P = 0.003). Using logistic regression model...