A5042518391- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Chronic Disease Management Strategies
- Transplantation: Methods and Outcomes
- Nursing Diagnosis and Documentation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Pediatric health and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Organ Transplantation Techniques and Outcomes
- Pleural and Pulmonary Diseases
- Polyomavirus and related diseases
- Delphi Technique in Research
- Frailty in Older Adults
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Health and Mental Health
- Emergency and Acute Care Studies
- Viral-associated cancers and disorders
- Nutrition and Health in Aging
- Obstructive Sleep Apnea Research
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2025
Pulmonary and Critical Care Associates
2012-2023
Spaulding Rehabilitation Hospital
2017-2022
Society of Thoracic Surgeons
2018
Lovelace Respiratory Research Institute
2014-2017
Pulmonary Associates
2017
Hospital Universitario de Gran Canaria Doctor Negrín
2014-2016
GlaxoSmithKline (Sweden)
2015
AstraZeneca (Canada)
2015
Patients with chronic obstructive pulmonary disease (COPD) are afflicted by comorbidities. Few studies have prospectively evaluated COPD comorbidities and mortality risk.To evaluate risk.We followed 1,664 patients in five centers for a median of 51 months. Systematically, 79 were recorded. We calculated risk using Cox proportional hazard, developed graphic representation the prevalence strength association to form "comorbidome". A comorbidity index (COPD specific test [COTE]) was constructed...
Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume 1 second (FEV1) over time. Yet it possible that a normal FEV1 could also lead COPD persons whose maximally attained less than population norms.We stratified participants three independent cohorts (the Framingham Offspring Cohort, the Copenhagen City Heart Study, and Lovelace Smokers Cohort) according lung function (FEV1 ≥80% or <80% of predicted value) at cohort inception...
Multimorbidity frequently affects the ageing population and their co-existence may not occur at random. Understanding interactions that with clinical variables could be important for disease screening management. In a cohort of 1969 chronic obstructive pulmonary (COPD) patients 316 non-COPD controls, we applied network-based analysis to explore associations between multiple comorbidities. Clinical characteristics (age, degree obstruction, walking, dyspnoea, body mass index) 79 comorbidities...
The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial. To evaluate the prevalence and stability a high level eosinophils (≥300 cells·μL –1 ) its relationship to outcomes, we determined at baseline over 2 years 424 COPD patients (forced expiratory volume 1 s (FEV 60% predicted) 67 smokers without from CHAIN cohort, 308 BODE cohort. We related eosinophil levels exacerbations survival using Cox hazard analysis. In patients, 15.8% cohort 12.3% had...
Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but its role in pathogenesis chronic obstructive pulmonary disease (COPD) unclear. We measured CC16 expression humans with and without COPD function a cigarette smoke (CS)-induced murine model. Airway was patients, smokers non-smokers. exposed wildtype (WT) CC16(-/-)mice to CS or air for up 6 months, expression, inflammation, alveolar septal apoptosis, airspace enlargement, mucin 5AC (MUC5AC) small...
The relationship between interstitial lung abnormalities (ILA) and exercise capacity has not been comprehensively evaluated.To assess the validity of 6-minute walk test in subjects with ILA, to examine association ILA distance (6MWD).Spearman correlation coefficients were used strength relationships 6MWD relevant measures dyspnea, health-related quality life, pulmonary function a cohort 2,416 people who smoke from COPDGene study. Unadjusted adjusted linear logistic regression models 6MWD.In...
Patients with chronic obstructive pulmonary disease (COPD) have increased lymphoid follicle (LF) counts. B cell-activating factor of tumor necrosis family (BAFF) regulates cells in health, but its role COPD pathogenesis is unclear.To determine whether BAFF expression LFs correlates severity, LF size or number, and/or readouts B-cell function LFs.We correlated immunostaining lung explants biopsies from nonsmoking control subjects (NSC), smokers without (SC), and patients the number LFs,...
<h3>Background</h3> The Global Obstructive Lung Disease (GOLD) 2011 revision recommends the multidimensional assessment of COPD including comorbidities and has developed a disease categories system (ABCD) attempting to implement this strategy. added value provided by quantifying integrating them indices not been explored. <h3>Objective</h3> Compare prognostic GOLD ABCD versus BMI, Obstruction, Dyspnea, Exercise (BODE) index, explore evaluation assessment. <h3>Methods</h3> From patients who...
Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of characteristically affecting elderly occur at earlier age in subjects diagnosis COPD.
Rationale: Patients with chronic obstructive pulmonary disease (COPD) frequently have albuminuria (indicative of renal endothelial cell injury) associated hypoxemia.Objectives: To determine whether (1) cigarette smoke (CS)-induced and injury explains the association between COPD, (2) CS-induced is linked to increases in oxidative stress–advanced glycation end products (AGEs) receptor for AGEs (RAGE) pathway, (3) enalapril (which has antioxidant properties) limits progression by reducing...
We tested whether emphysema progression accompanies enhanced tissue loss in other body compartments 1817 patients from the ECLIPSE chronic obstructive pulmonary disease (COPD) cohort. Clinical and selected systemic biomarker measurements were compared subjects grouped by quantitative tomography scan quartiles using percentage of low attenuation area (LAA%). Lowest highest quartile had amino-acid metabolomic profiles. related LAA% to 3 years decline lung function (forced expiratory volume 1 s...
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) document has modified the grading system directing pharmacotherapy, but how this relates to previous one from 2015 and comorbidities, hospitalizations, mortality risk is unknown.The aim of study was evaluate changes in GOLD groups 2017 assess impact on severity, within each group.We prospectively enrolled followed, a mean 5 years, 819 patients with chronic obstructive pulmonary disease (84% male) clinics Spain United States....
Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We RNA-sequencing profiling of large-airway epithelium, alveolar macrophage blood samples from the same subset COPD cases controls COPDGene who underwent bronchoscopy at a single center. Using statistical set enrichment approaches, we sought improve understanding by studying sets pathways across these tissues, beyond individual genomic determinants. differential...
The availability of chest computed tomography (CT) imaging can help diagnose comorbidities associated with chronic obstructive pulmonary disease (COPD). Their systematic identification and relationship all-cause mortality have not been explored. Furthermore, whether their CT-detected prevalence differs from clinical diagnosis is unknown.The 10 CT-assessed was retrospectively determined at baseline in 379 patients (71% men) mild to severe COPD attending clinics. Anthropometrics, smoking...
Background The lifetime risk of developing clinical COPD among smokers ranges from 13% to 22%. Identifying at-risk individuals who will develop overt disease in a reasonable timeframe may allow for early intervention. We hypothesised that readily available and physiological variables could help identify ever-smokers at higher chronic airflow limitation (CAL). Methods Among 2273 Lovelace Smokers’ Cohort (LSC) participants, we included 677 (mean age 54 years) with normal spirometry baseline...
Rationale: Contrary to the general population, in patients with chronic obstructive pulmonary disease (COPD) a low body mass index (BMI) is associated excess mortality, while obesity appears protective (obesity paradox). We hypothesized that BMI distinct number and expression of comorbidities COPD. The type comorbidity may relate mortality variability. Objectives Methods: followed 1659 COPD for median 51 months [IQR 27-77] detailed records tracking function, exercise capacity, dyspnea,...
Chronic obstructive pulmonary disease (COPD), although frequent in older individuals, can also occur at younger age; this latter population has not been well described. We reviewed the functional progression of 1708 patients with COPD attending clinics. Those three or more annual spirometries were divided into those who, enrolment, ≤ 55 (n = 103) ≥ 65 463) years age (younger and COPD, respectively). Baseline changes lung function (forced expiratory volume 1 s (FEV1)) BODE (body mass index,...
Abstract Rationale and objective Patients with chronic obstructive pulmonary disease (COPD), usually diagnosed after the 6th decade, frequently suffer from comorbidities. Whether COPD patients 50 years or younger (Young COPD) have similar comorbidities same frequency mortality impact as aged-matched controls older is unknown. Methods We compared comorbidity number, prevalence type in 3 groups of individuals ≥ 10 pack-years smoking: A Young ( ≤ years) group (n = 160), an age-balanced control...
Rationale: The mean pulmonary arterial wedge pressure (mPAWP) is the critical hemodynamic factor differentiating group 1 hypertension (PAH) from 2 associated with left heart disease. Despite discrepancy between mPAWP upper physiologic normal and current PAH definitions, implications of initial for clinical trajectory are poorly understood. Objectives: To model longitudinal trajectories in over 10 years examine factors membership. Methods: Adult patients two or more right catheterizations...
The value and timing of multidimensional assessments in chronic obstructive pulmonary disease (COPD) remains unclear because there is little information about their variability relationship to outcome. aim this study was determine the progression COPD using clinical spirometric over time with mortality as We determined annual intra-individual forced expiratory volume 1 s (FEV1) BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index 403 patients at least five...