A5041777840- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Cerebral Palsy and Movement Disorders
- Family and Disability Support Research
- Infant Health and Development
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Congenital Heart Disease Studies
- Pediatric Pain Management Techniques
- Language Development and Disorders
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
- Tactile and Sensory Interactions
- Heavy Metal Exposure and Toxicity
- Child and Adolescent Health
- Childhood Cancer Survivors' Quality of Life
- Respiratory Support and Mechanisms
- EEG and Brain-Computer Interfaces
- Birth, Development, and Health
- Multisensory perception and integration
- Neonatal and Maternal Infections
- Epilepsy research and treatment
- Trace Elements in Health
- Anesthesia and Neurotoxicity Research
Nationwide Children's Hospital
2016-2025
Children's Healthcare of Atlanta
2021-2025
Emory University
2021-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2021-2025
Research Network (United States)
2018-2025
The Ohio State University
2017-2025
United Cerebral Palsy
2025
Grady Memorial Hospital
2025
Emory University Hospital Midtown
2025
Cohort (United Kingdom)
2024
Cerebral palsy (CP) is the most common childhood physical disability. Early intervention for children younger than 2 years with or at risk of CP critical. Now that an evidence-based guideline early accurate diagnosis exists, there a need to summarize effective, CP-specific and conduct new trials harness plasticity improve function increase participation. Our recommendations apply primarily high CP, aged 0 years.To systematically review best available evidence about interventions across 9...
Neonatal hypoxic–ischemic encephalopathy is an important cause of death as well long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects infants with encephalopathy, but its on neurodevelopmental outcomes when given conjunction therapeutic hypothermia are unknown.
Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment the second postnatal week can improve survival without bronchopulmonary and adverse neurodevelopmental effects unknown. We conducted trial involving infants who had gestational age of less than 30 weeks been intubated for at least 7 days 14 28 days. Infants were randomly assigned receive either (4 mg...
To identify developmental trajectories of impaired hand function in infants aged 3 to 15 months with unilateral cerebral palsy (CP). Sixty-three (37 male; median gestational age 37 weeks [interquartile range 30-39.1 weeks]) recruited as part a randomized trial confirmed diagnosis CP were included. All received early upper limb therapy. The Hand Assessment for Infants (HAI) was completed at baseline and until 12 corrected age. Group-based trajectory modelling identified groups similar...
Cerebral organoids (COs) are rapidly accelerating the rate of translational neuroscience based on their potential to model complex features developing human brain. Several studies have examined electrophysiological and neural network COs; however, no study has comprehensively investigated developmental trajectory properties in whole-brain COs correlated these with developmentally linked morphological cellular features. Here, we profiled neuroelectrical activities over span 5 months a...
We conducted a randomized trial to test the hypothesis that mother's voice played through pacifier-activated music player (PAM) during nonnutritive sucking would improve development of ability and promote more effective oral feeding in preterm infants.Preterm infants between 34 0/7 35 6/7 weeks' postmenstrual age, including those with brain injury, who were taking at least half their feedings enterally less than orally, randomly assigned receive 5 daily 15-minute sessions either PAM recorded...
Objective: The aim of this study was to determine which initial surgical treatment results in the lowest rate death or neurodevelopmental impairment (NDI) premature infants with necrotizing enterocolitis (NEC) isolated intestinal perforation (IP). Summary Background Data: impact laparotomy versus peritoneal drainage for NEC IP on NDI extremely low birth weight is unknown. Methods: We conducted largest feasible randomized trial 20 US centers, comparing drainage. primary outcome a composite at...
Early diagnosis of cerebral palsy (CP) is critical in obtaining evidence-based interventions when plasticity greatest. In 2017, international guidelines for early detection CP were published on the basis a systematic review evidence. Our study aim was to reduce age at throughout network 5 diverse US high-risk infant follow-up programs through consistent implementation these guidelines.
The ability to predict neurodevelopmental impairment (NDI) for infants diagnosed with hypoxic ischemic encephalopathy (HIE) is important parental guidance and clinical treatment as well stratification of patients future neurotherapeutic studies.
With improved survival rates, short- and long-term respiratory complications of premature birth are increasing, adding significantly to financial health burdens in the United States. In response, May 2010, National Institutes Health (NIH) Heart, Lung, Blood Institute (NHLBI) funded a 5-year $18.5 million research initiative ultimately improve strategies for managing preterm low weight infants. Using collaborative, multi-disciplinary structure, resulting Prematurity Respiratory Outcomes...
For parents, the experience of having an infant in NICU is often psychologically traumatic. No parent can be fully prepared for extreme stress and range emotions caring a critically ill newborn. As health care providers familiar with NICU, we thought that understood impact on parents. But were not to see children our own families as patients. Here are some lessons has taught us. We offer these hope helping professionals consider balanced view NICU's families.
Premature infants are at risk for abnormal sensory development due to brain immaturity birth and atypical early experiences in the Neonatal Intensive Care Unit. This altered can have downstream effects on other more complex developmental processes. There currently no interventions that address rehabilitation of function neonatal period. study is a randomized controlled trial preterm enrolled 32–36 weeks postmenstrual age either standard care or plus multisensory intervention order effect as...
Periventricular hemorrhagic infarction (PVHI) is a major contributing factor to poor neurodevelopmental outcomes in preterm infants. We hypothesized that surviving infants with unilateral PVHI would have more favorable than those bilateral PVHI.This was multicenter, retrospective study of who were admitted 3 NICUs North Carolina from 1998 2004. The clinical course and late neuroimaging studies 69 weighed <1500 g had confirmed on early cranial ultrasonography reviewed. A predictive model for...
<h3>Background</h3> Sensory experience is the basis for learning in infancy. In older children, abnormal sensory reactivity associated with behavioural and developmental disorders. We hypothesised that preterm infants, during infancy would be perinatal characteristics correlate 2-year neurodevelopmental outcomes. <h3>Methods</h3> conducted a prospective observational study of infants birth weight ≤1500 g using Test Function Infants (TSFI) first year. gestational age ≤30 weeks were tested...
Aim Neurodevelopmental delay in childhood is common infants born preterm, but difficult to predict before leave the neonatal intensive care unit ( NICU ). We hypothesized that event‐related potential ERP ) methodology characterizing cortical differentiation of speech sounds hospitalized would cognitive and language outcomes during early childhood. Methods conducted a prospective study 57 (34 male, gestational age at birth 24–40wks), quantifying amplitude responses discharge (median 37.1wks),...