A5062460881- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Neonatal and fetal brain pathology
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Gestational Diabetes Research and Management
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Infant Development and Preterm Care
- Health Systems, Economic Evaluations, Quality of Life
- Maternal and Perinatal Health Interventions
- Systemic Lupus Erythematosus Research
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Systemic Sclerosis and Related Diseases
- Meta-analysis and systematic reviews
- Neuroscience of respiration and sleep
- Anesthesia and Pain Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Assisted Reproductive Technology and Twin Pregnancy
- Statistical Methods in Clinical Trials
- Maternal and fetal healthcare
- Neonatal Health and Biochemistry
- Venous Thromboembolism Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
The University of Texas Health Science Center at Houston
2016-2025
Research Network (United States)
2022-2025
Houston Institute for Clinical Research
2024-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2022-2025
Center for Clinical Research (United States)
2015-2024
Memorial Hermann
2017-2024
University of Houston
2023-2024
Texas Medical Center
2017-2024
Fundació Salut i Envelliment UAB
2023
Jackson Memorial Hospital
2022
<h3>Importance</h3> Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy 36 weeks' later gestation. To our knowledge, hypothermia trials have not been performed in presenting hours. <h3>Objective</h3> estimate the probability that to 24 risk of 18 months among encephalopathy. <h3>Design, Setting, and Participants</h3> A randomized clinical trial was conducted between April 2008 June 2016 gestation moderate severe...
<h3>Importance</h3> Hypothermia at 33.5°C for 72 hours neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% 55%; longer cooling and deeper are neuroprotective in animal models. <h3>Objective</h3> To determine if duration (120 hours), (32.0°C), both superior neonates who full-term with moderate severe encephalopathy. <h3>Design, Setting, Participants</h3> A randomized, 2 × factorial design clinical trial performed 18 US centers the Eunice Kennedy Shriver National...
Patient-centered medical homes have not been shown to reduce adverse outcomes or costs in adults children with chronic illness.To assess whether an enhanced home providing comprehensive care prevents serious illness (death, intensive unit [ICU] admission, hospital stay >7 days) and/or reduces among illness.Randomized clinical trial of high-risk (≥3 emergency department visits, ≥2 hospitalizations, ≥1 pediatric ICU admissions during previous year, and >50% estimated risk for hospitalization)...
Hypothermia for 72 hours at 33.5°C neonatal hypoxic-ischemic encephalopathy reduces death or disability, but rates continue to be high. To determine if cooling 120 a temperature of 32.0°C disability age 18 months in infants with encephalopathy. Randomized 2 × factorial clinical trial neonates (≥36 weeks' gestation) US centers the Eunice Kennedy Shriver National Institute Child Health and Human Development Neonatal Research Network between October 2010 January 2016. A total 364 were randomly...
Importance Hypothermia begun less than 6 hours after birth reduces death or disability in infants with encephalopathy due to hypoxia-ischemia at 36 more weeks’ gestation. Trials of hypothermia for younger gestation are lacking. Objective To assess the probability that decreases 33 35 moderate severe hypoxic-ischemic encephalopathy. Design, Setting, and Participants This randomized clinical trial was conducted between July 2015 December 2022 birth. Bayesian intention-to-treat analyses were...
It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g less).
In vivo MRI volumetric analysis enables investigators to evaluate the extent of tissue loss following traumatic brain injury (TBI). However, studies pediatric TBI are sparse, and there have been no date in children examining specific subregions prefrontal temporal lobes. this study, volumetry was used volume differences whole brain, prefrontal, temporal, posterior regions moderate severe as compared uninjured similar age demographic characteristics. The group had significantly reduced...
This study evaluated the prevalence and specificity of diagnostic criteria for postconcussional syndrome (PCS) in 178 adults with mild to moderate traumatic brain injury (TBI) 104 extracranial trauma. Diagnostic Statistical Manual Mental Disorders, Fourth Edition (DSM-IV) International Classification Diseases (ICD-10) PCS were 3 months after injury. The results showed that was higher using ICD-10 (64%) than DSM-IV (11%). Specificity TBI limited because often fulfilled by patients authors...
There are no identified clinical markers that reliably predict long-term progression of interstitial lung disease (ILD) in systemic sclerosis (SSc; scleroderma). Elevated C-reactive protein (CRP) levels have been reported SSc patients. We examined the predictive significance CRP level for ILD a large early cohort.First, were compared between baseline samples 266 patients enrolled Genetics Versus Environment Scleroderma Outcome Study cohort and 97 unaffected matched controls. Subsequently,...
Preclinical studies using bone marrow derived cells to treat traumatic brain injury have demonstrated efficacy in terms of blood-brain barrier preservation, neurogenesis, and functional outcomes. Phase 1 clinical trials mononuclear infused intravenously children with severe safety potentially a central nervous system structural preservation treatment effect. This study sought confirm the safety, logistic feasibility, potential effect size preservation/inflammatory biomarker mitigation adults...
Abstract Objective To determine whether robotic ventral hernia repair is associated with fewer days in the hospital 90 after surgery compared laparoscopic repair. Design Pragmatic, blinded randomized controlled trial. Setting Multidisciplinary clinics Houston, USA. Participants 124 patients, deemed appropriate candidates for elective minimally invasive repair, consecutively presenting from April 2018 to February 2019. Interventions Robotic (n=65) versus (n=59). Main outcome measures The...
Objective: The aim of this study was to determine which initial surgical treatment results in the lowest rate death or neurodevelopmental impairment (NDI) premature infants with necrotizing enterocolitis (NEC) isolated intestinal perforation (IP). Summary Background Data: impact laparotomy versus peritoneal drainage for NEC IP on NDI extremely low birth weight is unknown. Methods: We conducted largest feasible randomized trial 20 US centers, comparing drainage. primary outcome a composite at...
We conducted a randomized exploratory study to assess safety and the probability of favorable outcome with adjunctive argatroban, direct thrombin-inhibitor, administered recombinant tissue-type plasminogen activator (r-tPA)-treated ischemic stroke patients.Patients treated standard-dose r-tPA, not receiving endovascular therapy, were receive no argatroban or (100 μg/kg bolus) followed by infusion either 1 (low dose) 3 per minute (high for 48 hours. Safety was incidence symptomatic...
Abstract Emerging urinary biomarkers continue to show promise in evaluating lupus nephritis (LN). Here, we screen urine from active LN patients for 1129 proteins using an aptamer-based platform, followed by ELISA validation two independent cohorts comprised of 127 inactive lupus, 107 LN, 67 non-renal and 74 healthy controls, three different ethnicities. Urine that best distinguish disease are ALCAM, PF-4, properdin, VCAM-1 among African-Americans, sE-selectin, VCAM-1, BFL-1 Hemopexin...
Inguinal hernia repair in preterm infants is common and associated with considerable morbidity. Whether the inguinal should be repaired prior to or after discharge from neonatal intensive care unit controversial. To evaluate safety of early vs late surgical for an hernia. A multicenter randomized clinical trial including diagnosed during initial hospitalization was conducted between September 2013 April 2021 at 39 US hospitals. Follow-up completed on January 3, 2023. In strategy, underwent...
Abstract Autologous bone marrow mononuclear cells (BMMNCs) infused after severe traumatic brain injury have shown promise for treating the injury. We evaluated their impact in children, particularly hypothesized ability to preserve blood–brain barrier and diminish neuroinflammation, leading structural CNS preservation with improved outcomes. performed a randomized, double-blind, placebo-sham-controlled Bayesian dose-escalation clinical trial at two children's hospitals Houston, TX Phoenix,...
This article presents a Bayesian approach to forecast mortality rates. formalizes the Lee–Carter method as statistical model accounting for all sources of variability. Markov chain Monte Carlo methods are used fit and sample from posterior predictive distribution. paper also shows how multiple imputations can be readily incorporated into handle missing data some possible extensions model. The methodology is applied U.S. male data. Mortality rate forecasts formed period 1990–1999 based on...
Vascular diseases are the principal causes of death and disability in people with diabetes. At same time, studies suggest a protective role diabetes development abdominal aortic aneurysms. We sought to determine whether is associated decreased hospitalization due thoracic aneurysms dissections (TAAD).We used 2006 2007 Nationwide Inpatient Sample (NIS) TAAD discharge rates. Control subjects were randomly selected achieve three controls per case. Predictor variables multilevel logistic...
Reporting of absolute risk difference (RD) is recommended for clinical and epidemiological prospective studies. In analyses multicenter studies, adjustment center necessary when randomization stratified by or there large variation in patients outcomes across centers. While regression methods are used to estimate RD adjusted baseline predictors clustering, no formal evaluation their performance has been previously conducted.We performed a simulation study evaluate 6 fitted under generalized...
Objective There are few clinical predictors of the progression systemic sclerosis (SSc)–related interstitial lung disease (ILD). The purpose this study was to examine predictive significance key cytokines for long‐term ILD and survival in 2 independent cohorts patients with early SSc. Methods Plasma levels 11 Th1/Th2 (interleukin‐1β [IL‐1β], IL‐5, IL‐6, IL‐8, IL‐10, IL‐12, IL‐13, tumor necrosis factor, CCL2, interferon‐inducible T cell α chemoattractant, interferon‐γ–inducible 10‐kd protein)...