A5039770022- Immune cells in cancer
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Prenatal Substance Exposure Effects
- Neuroscience of respiration and sleep
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Neonatal Health and Biochemistry
- Blood Coagulation and Thrombosis Mechanisms
- Infant Health and Development
- Traumatic Brain Injury and Neurovascular Disturbances
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Health
- Congenital Heart Disease Studies
- Family and Disability Support Research
- Cerebral Venous Sinus Thrombosis
- Children's Physical and Motor Development
- Opioid Use Disorder Treatment
- Family and Patient Care in Intensive Care Units
- Attention Deficit Hyperactivity Disorder
- Childhood Cancer Survivors' Quality of Life
- Venous Thromboembolism Diagnosis and Management
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
Nationwide Children's Hospital
2017-2025
The Ohio State University
2009-2025
Research Network (United States)
2023-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024-2025
National Institutes of Health
2024
The Ohio State University Wexner Medical Center
2017-2022
Google (United States)
2022
Perinatal Institute
2019
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2009-2011
The Barbara Ann Karmanos Cancer Institute
2011
Abstract This study assessed the efficacy of a 5-week, intensive working memory training program for 52 children and adolescents (ages 7–17) who had Attention-Deficit/Hyperactivity Disorder (ADHD) other comorbid diagnoses. provided treatment replication since waitlist control group also completed was included in follow-up data analyses. Parents teachers paper-and-pencil measures memory, executive functioning, ADHD symptoms at baseline, posttreatment, 4-month follow-up. Parent ratings...
Neonatal hypoxic–ischemic encephalopathy is an important cause of death as well long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects infants with encephalopathy, but its on neurodevelopmental outcomes when given conjunction therapeutic hypothermia are unknown.
Abstract Our group and others have determined that immune effector cells from patients with advanced cancers exhibit reduced activation of IFN signaling pathways. We hypothesized increases in regulatory termed myeloid-derived suppressor (MDSC) could interfere the host response to tumors by inhibiting cell responsiveness IFNs. The C26 murine adenocarcinoma model was employed study function malignancy. C26-bearing mice had significantly elevated levels GR1+CD11b+ MDSC as compared control mice,...
The ability to predict neurodevelopmental impairment (NDI) for infants diagnosed with hypoxic ischemic encephalopathy (HIE) is important parental guidance and clinical treatment as well stratification of patients future neurotherapeutic studies.
ABSTRACT Neurologic insults in infancy can have significant long‐term effects on developmental processes including attention and learning; however, the heterogeneity of diagnoses treatments this population often lead to exclusion from interventional trials improve outcomes. This study sought determine whether hospitalized infants with neural capacity attend engage an intervention leveraging recorded mother's voice contingent non‐nutritive suck (NNS). Eighty‐four insult were randomized...
Importance Hypothermia begun less than 6 hours after birth reduces death or disability in infants with encephalopathy due to hypoxia-ischemia at 36 more weeks’ gestation. Trials of hypothermia for younger gestation are lacking. Objective To assess the probability that decreases 33 35 moderate severe hypoxic-ischemic encephalopathy. Design, Setting, and Participants This randomized clinical trial was conducted between July 2015 December 2022 birth. Bayesian intention-to-treat analyses were...
Introduction: Neurodevelopmental surveillance is critical for high-risk infants following neonatal intensive care discharge and traditionally performed in-person. COVID-19 interruption of regular necessitated a rapid development telehealth models effective standardized care. Methods: We used implementation science lean methodologies to develop an neurodevelopmental program infants. Interventions included reorganization visit flow processes toolkit neurological developmental assessments....
Aim: To define a developmental trajectory in infants with neonatal opioid withdrawal syndrome (NOWS) and determine whether impacted domain varies type of antenatal exposure. Methods: We performed retrospective cohort study treated pharmacologically for NOWS assessed using standardized schedule follow-up visits. compared outcomes the population to published norms one-sample t-tests. Multivariable models examined associations exposures addition opioids. Results: In our 285 9-12 month testing,...
<h3>BACKGROUND AND PURPOSE:</h3> Advanced imaging techniques have allowed earlier and more accurate detection of cerebral deep medullary vein thrombosis infarction. Our objective was to develop an MR scoring system evaluate the severity white matter injury in neonates with <h3>MATERIALS METHODS:</h3> This a retrospective study infants born ≥32 weeks9 gestation (2000–2016) diagnosed infarction on neuroimaging first 30 days life. A 102-point global score developed. images were scored by 2...
Aim: To examine associations between the deep medullary vein white matter injury global severity scoring system and neurodevelopmental impairment. Methods: This is a prospective observational cohort study of infants born at ≥32 weeks, diagnosed with thrombosis infarction on neuroimaging in first month life. Developmental testing was performed using validated measures for early, preschool, school-age follow-up. Results: Nineteen (37%) patients had major Global score higher among impairment...
Aim To determine whether infants with intrauterine drug exposure (IUDE) are similarly at risk for cerebral palsy (CP) as other high‐risk populations, CP classification differs based on IUDE status, and describe the association of specific substances among exposed infants. Method This was a retrospective analysis in follow‐up program ( n =5578) between January 2014 February 2018 history or who received diagnosis. rates were compared using two‐sample z ‐tests. assessed Fisher’s exact,...
Purpose: The aims of this study were, in a cohort children with neonatal opioid withdrawal syndrome (NOWS), (a) to report 1-year neurodevelopmental outcomes and specifically characterize speech, language, hearing (b) the prevalence cleft lip and/or palate. Method: This prospective observational includes newborns confirmed utero exposure who received pharmacological treatment for NOWS. During 1-year-old developmental visits, we administered standardized assessments (Bayley Scales Infant...
Progress in maternal child health has been hampered by poor rates of outpatient follow up for postpartum individuals. Primary care after delivery can effectively detect and treat several pregnancy-related complications comorbidities, but linkage to primary remains low. In this manuscript, we share the experience implementing a novel mother-infant dyad program, Multimodal Maternal Infant Perinatal Outpatient Delivery System (MOMI PODS), improve community resource access via integration into...
To test the hypothesis that cerebral blood flow (CBF) assessed with arterial spin labelling (ASL) MRI is increased and standardised neurological examination altered in infants neonatal opioid withdrawal syndrome (NOWS) compared those without.Prospective cohort study.Level IV intensive care unit outpatient primary centre.Infants NOWS receiving pharmacological treatment unexposed controls matched for gestational age at birth post-menstrual MRI.CBF by ASL on non-sedated 3-Tesla Hammersmith...