Integration of a cDNA copy the human immunodeficiency virus (HIV) genome is mediated by an HIV-1-encoded enzyme, integrase (IN), and required for productive infection CD4+ lymphocytes. It had been shown that 3,5-dicaffeoylquinic acid two analogues were potent selective inhibitors HIV-1 IN in vitro. To determine whether inhibition dicaffeoylquinic acids was limited to 3,5 substitution, 3,4-, 4,5-, 1,5-dicaffeoylquinic tested replication tissue culture All found inhibit at concentrations...

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) and other retroviruses require integration of a double-stranded DNA copy the RNA genome into host cell chromosome for productive infection. The viral enzyme, integrase, catalyzes retroviral represents an attractive target developing antiretroviral agents. We identified several derivatives dicaffeoylquinic acids (DCQAs) that inhibit HIV-1 replication in tissue culture catalytic activities integrase vitro. specific step at which DCQAs vitro...

Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral that affects children worldwide. The etiology of ADHD complex and not fully understood. Earlier studies associated elevated levels manganese (Mn) with learning problems, attention deficits, ADHD. Furthermore, it has also been shown the dopamine (DA) system, primary site action pharmacological treatments, influenced by high Mn. Recent have suggested Mn accumulates in dopaminergic neurons via presynaptic transporter...

Introdução: A Hipertensão Arterial Sistêmica (HAS) é uma condição prevalente que aumenta o risco de complicações cardiovasculares e renais. O tratamento envolve IECA, BRA inibidores da neprilisina, visando controle pressão arterial a redução eventos adversos. Estratégias individualizadas, considerando comorbidades, são essenciais para manejo eficaz doença. Objetivo: Avaliar eficácia novos agentes anti-hipertensivos no hipertensão na do cardiovascular. Metodologia: Revisão integrativa estudos...

Niemann-Pick type C (NPC) disease is a rare neurodegenerative disorder with wide spectrum of clinical manifestations and genetic variability. This cross-sectional study aimed to comprehensively describe the neuropsychological impact NPC investigate its correlation specific genotypes. Eight patients from six unrelated families were included in this study. Their age at symptom onset ranged between 2 16 years, all presenting ataxia, dysarthria, cognitive impairment. Following initiation...

Several studies worldwide have pointed to depression and anxiety symptoms as being related adolescent smoking. The aim of this study was investigate, the potential link cigarette smoking with depression, anxiety, suicidal ideation influence gender on these relationships in Brazilian adolescents.Associations Children Depressive Inventory version 2 (CDI2) scores, Hamilton Anxiety Scale (HAM-A) poor school performance (i.e., grade retention) were examined 988 students (age range, 11-17 years)...

Abstract Background Early-onset depressive disorders can have severe consequences both from developmental and functional aspects. The etiology of is complex multi-factorial, with an intricate interaction among environmental factors genetic predisposition. While data studies on adults suggest that caffeine fairly safe, effects in children, who are period rapid brain development, currently unknown. Furthermore, systematic research addressing the relationship between symptoms children...

Sleep deprivation is extremely common in contemporary society, and considered to be a frequent cause of behavioral disorders, mood, alertness, cognitive performance. Although the impacts sleep have been studied extensively various experimental paradigms, very few studies addressed impact on central auditory processing (CAP). Therefore, we examined CAP, for which there sparse information. In present study, thirty healthy adult volunteers (17 females 13 males, aged 30.75±7.14 years) were...

Objective: The validity of a diagnosis ADHD in children with high intelligence quotient (IQ) remains controversial. Using multidisciplinary approach, rigorous diagnostic criteria, and worldwide-validated psychometric instruments, we identified group attending public schools southern Brazil for co-occurrence IQ ADHD. Method: Students schools, the first to fifth grades, were referred our Research Center behavioral and/or learning difficulties. These completed clinical, psychiatric,...

Abstract: We recently reported that lithium ions induced anup‐regulation of cysteine string protein (CSP) gene expression in nerve growthfactor (NGF)‐differentiated PC12 cells but not undifferentiated cells.Concomitantly, two other proteins regulated secretorypathways, synaptophysin (SY) and SNAP‐25, was unaffected by lithium. To assessfurther the specificity this effect lithium, we used cDNA arrays. Ourdata indicate increase level mRNA for suchas secretogranin II vesicular monoamine...

Objective: To test the effects of a virtual reality (VR) balance rehabilitation program in patients diagnosed with SCAs. Materials and methods: A prospective observational study was carried out cohort 28 SCAs, including eight females 20 males, 15–70 years age (mean, 41.5 ± 16.9 years). Patients were submitted to otorhinolaryngological assessment exclude any kind middle ear impairments that may hinder exam results, vestibular evaluation verify existence disorders, site lesion. The Dizziness...

Townes-Brocks syndrome (TBS) is a rare autosomal dominant condition characterized by renal, anal, limb, and auditory abnormalities. TBS diagnosis can be challenging in settings where genetic analysis not readily available. traits overlap with those of Goldenhar VACTERL syndromes. Here, we present the case 5-year-old Brazilian boy born an anorectal abnormality, limb external ears malformations, genitourinary anomalies, congenital heart defect. Genetic revealed SALL1 nonsense mutation. The...

Abstract: Lithium is a well established pharmacotherapy for the treatment of recurrent manic‐depressive illness. However, mechanism by which lithium exerts its therapeutic action remains elusive. Here we report that at 1 m M significantly increased expression cysteine string proteins (CSPs) in pheochromocytoma cell line (PC12 cells) differentiated nerve growth factor. These cells concomitantly exhibited CSPs their bodies and boutons. Enhanced CSP was also observed brain rats fed...

Recent studies have suggested that children with attention-deficit hyperactivity disorder (ADHD) may benefit from computerized cognitive training. Therapy implementation is especially complicated when ADHD associated learning disorders (LDs). This study tested the efficacy of a computer-based training program, namely, (CCT), in comorbid an LD (ADHD-LD), or without psychostimulant medication.After diagnostic evaluations, 27 ADHD-LD (8 unmedicated and 19 medicated) participated CCT, which...

Introduction Mucopolysaccharidoses (MPS) constitute a group of progressive and multisystemic inherited metabolic diseases that profoundly affect both the mental health patients wellbeing their families. This study aims to evaluate impact MPS on family functioning related factors. Methods results Twenty-five with MPS, including types I ( n = 4), II 11), IIIB 2), IVA 3), VI 5), families participated in this study. The mean patient age was 13 years [standard deviation (SD): 7.7 years]....

This study aimed to investigate the prevalence of autism spectrum disorder and its possible correlations with clinical characteristics in patients infantile epileptic spasms syndrome a single center Brazil.

Receiver operating characteristic curve analysis of the Child Behavior Checklist and Teacher's Report Form for assessing autism spectrum disorder in preschool-aged children Tiago S Bara,1,2 Antonio C Farias,1–4 Erico PG Felden,5 Mara L Cordeiro1,2,6 1Neurosciences Core, Pelé Pequeno Príncipe Research Institute, 2Faculdades Príncipe, 3Department Neuropediatrics, Children's Hospital, 4School Medicine, University Positivo, Curitiba, 5Centro de Ciências da Saúde e do Esporte (CEFID) Universidade...

Mucopolysaccharidosis type III (MPS III) or Sanfilippo syndrome is the most common form of MPS, in which neurological involvement all stages disease prominent. The current study aimed to comprehensively describe profile children and adolescents with MPS who visited largest pediatric hospital South America. A prospective/retrospective cohort analysis was performed on 10 patients from eight unrelated families. Most <12 months age had achieved development milestones within expected range for...

Human parvovirus B19 (B19) infection can produce a spectrum of clinical syndromes, including neurological manifestations, most notably encephalitis. Although symptoms suggestive autoimmune disease in patients with have been previously described, clear association encephalitis has yet to be established.We describe the case 6-year-old boy who was hospitalized due status epilepticus, which evolved super-refractory epilepticus that only mildly responsive anticonvulsant drugs.A cerebrospinal...

Abstract Lithium salts are used to treat manic‐depressive disorders; however, the mechanism by which lithium produces its therapeutic benefit remains obscure. The action of may involve alterations proteins important for regulating synaptic function. In this context, we observed recently that at therapeutically relevant concentrations enhanced expression cysteine string protein (csp) level both mRNA and protein, in cell culture rat brain. Several lines evidence have shown csps vital...