A5033359877- Multisensory perception and integration
- Olfactory and Sensory Function Studies
- Tactile and Sensory Interactions
- Visual perception and processing mechanisms
- Color perception and design
- Biochemical Analysis and Sensing Techniques
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Obsessive-Compulsive Spectrum Disorders
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Attention Deficit Hyperactivity Disorder
- Categorization, perception, and language
- Genetics and Neurodevelopmental Disorders
- Behavioral and Psychological Studies
- Face Recognition and Perception
- Healthcare Technology and Patient Monitoring
- Neuroscience and Neural Engineering
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Child Development and Digital Technology
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Eating Disorders and Behaviors
Vanderbilt Health
2016-2025
Vanderbilt University
2016-2025
Vanderbilt University Medical Center
2015-2024
Bethesda Hospital East
2024
John F. Kennedy Center for the Performing Arts
2012-2023
Center for Autism and Related Disorders
2020-2023
Allen Institute for Brain Science
2009-2022
Kennedy Center
2019-2022
Institute of Psychology
2022
Institute of Behavioral Sciences
2022
The new DSM-5 diagnostic criteria for autism spectrum disorders (ASDs) include sensory disturbances in addition to the well-established language, communication, and social deficits. One disturbance seen ASD is an impaired ability integrate multisensory information into a unified percept. This may arise from underlying impairment which individuals with have difficulty perceiving temporal relationship between cross-modal inputs, important cue integration. Such impairments processing cascade...
1. The properties of visual-, auditory-, and somatosensory-responsive neurons, as well neurons responsive to multiple sensory cues (i.e., multisensory), were examined in the superior colliculus rhesus monkey. Although superficial layer responded exclusively visual stimuli inputs predominated deeper layers, there was also a rich nonvisual multisensory representation colliculus. More than quarter (27.8%) deep population from more single modality. In contrast, 37% only cues, 17.6% auditory...
Autism spectrum disorders (ASD) form a continuum of neurodevelopmental disorders, characterized by deficits in communication and reciprocal social interaction, as well repetitive behaviors restricted interests. Sensory disturbances are also frequently reported clinical autobiographical accounts. However, surprisingly few empirical studies have the fundamental features sensory multisensory processing ASD. The current study is structured to test for potential differences temporal function ASD...
The brain's ability to bind incoming auditory and visual stimuli depends critically on the temporal structure of this information. Specifically, there exists a window audiovisual integration within which are highly likely be bound together perceived as part same environmental event. Several studies have described bounds window, but few investigated its malleability. Here, plasticity in size was using perceptual learning paradigm participants were given feedback during two-alternative forced...
Autism spectrum disorders (ASD) are characterized by deficits in social reciprocity and communication, as well repetitive behaviors restricted interests. Unusual responses to sensory input disruptions the processing of both unisensory multisensory stimuli have also frequently been reported. However, specific aspects that disrupted ASD yet be fully elucidated. Recent published work has shown children with can integrate low-level audiovisual stimuli, but do so over an extended range time when...
Human multisensory systems are known to bind inputs from the different sensory modalities into a unified percept, process that leads measurable behavioral benefits. This integrative can be observed through illusions, including McGurk effect and sound-induced flash illusion, both of which demonstrate ability one modality modulate perception in second modality. Such integration is highly dependent upon temporal relationship inputs, with perceptual binding occurring within limited range...
Abstract Why are people with focal epilepsy not continuously having seizures? Previous neuronal signalling work has implicated gamma-aminobutyric acid balance as integral to seizure generation and termination, but is a high-level distributed brain network involved in suppressing Recent intracranial electrographic evidence suggested that seizure-onset zones have increased inward connectivity could be associated interictal suppression of activity. Accordingly, we hypothesize actively...
Visual and auditory cortices traditionally have been considered to be "modality-specific." Thus, their activity has thought unchanged by information in other sensory modalities. However, using functional magnetic resonance imaging (fMRI), the present experiments revealed that ongoing visual cortex could modulated information. In both cases, this cross-modal modulation of took form deactivation. Yet, deactivation response was not evident either cortical area during paired presentation...
Traditional cortical parcellation schemes have emphasized the presence of sharply defined visual, auditory, and somatosensory domains populated exclusively by modality-specific neurons (i.e., responsive to sensory stimuli from a single modality). However, modality-exclusivity this scheme has recently been challenged. Observations in variety species suggest that each these is subject influences other senses. Using cerebral cortex rat as model, present study systematically examined capability...
Wallace, Mark T., M. Alex Meredith, and Barry E. Stein. Multisensory integration in the superior colliculus of alert cat. J. Neurophysiol. 80: 1006–1010, 1998. The modality convergence patterns, sensory response properties, principles governing multisensory (SC) cat were found to have fundamental similarities those anesthetized animals. Of particular interest was observation that, a manner indistinguishable from animal, combinations two different stimuli significantly enhanced responses SC...
The development of multisensory neurons and integration was examined in the deep layers superior colliculus kittens ranging age from 3 to 135 d postnatal (dpn). Despite high proportion adult animals, no such were found during first 10 life. Rather, all sensory-responsive unimodal. (somatosensory-auditory) at 12 dpn, visually responsive not until 20 dpn. Early responded weakly sensory stimuli, had long latencies, large receptive fields, poorly developed response selectivities. Most...
1. Physiological methods were used to examine the pattern of inputs from different sensory cortices onto individual superior colliculus neurons. 2. Visual, auditory, and somatosensory influences anterior ectosylvian sulcus (AES) visual lateral suprasylvian (LS) cortex found converge multisensory neurons in cat colliculus. An excellent topographic relationship was between their target 3. Corticotectal derived solely unimodal Multisensory AES LS not antidromically activated 4. Orthodromic...
Multisensory integration refers to the process by which brain synthesizes information from different senses enhance sensitivity external events. In present experiments, animals were reared in an altered sensory environment visual and auditory stimuli temporally coupled but originated locations. Neurons superior colliculus developed a seemingly anomalous form of multisensory spatially disparate visual-auditory integrated same way that neurons normally location. The data suggest principles...
The majority of multisensory neurons in the cat superior colliculus (SC) are able to synthesize cross-modal cues (e.g., visual and auditory) thereby produce responses greater than those elicited by most effective single modality stimulus and, sometimes, predicted arithmetic sum their modality-specific responses. present study examined role corticotectal inputs from two cortical areas, anterior ectosylvian sulcus (AES) rostral aspect lateral suprasylvian (rLS), producing these response...