A5081914967- Multisensory perception and integration
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Sepsis Diagnosis and Treatment
- Tactile and Sensory Interactions
- Intensive Care Unit Cognitive Disorders
- Neuroendocrine regulation and behavior
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Hearing Loss and Rehabilitation
- Stress Responses and Cortisol
- Lung Cancer Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Adipose Tissue and Metabolism
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Birth, Development, and Health
- Cholinesterase and Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Organ Transplantation Techniques and Outcomes
Vanderbilt University Medical Center
2014-2025
Vanderbilt University
2012-2024
John F. Kennedy Center for the Performing Arts
2014-2024
Case Western Reserve University
2023
Cleveland Clinic
2023
Allen Institute for Brain Science
2013-2014
Kennedy Center
2014
University of Florida
2007
The new DSM-5 diagnostic criteria for autism spectrum disorders (ASDs) include sensory disturbances in addition to the well-established language, communication, and social deficits. One disturbance seen ASD is an impaired ability integrate multisensory information into a unified percept. This may arise from underlying impairment which individuals with have difficulty perceiving temporal relationship between cross-modal inputs, important cue integration. Such impairments processing cascade...
Importance Cefepime and piperacillin-tazobactam are commonly administered to hospitalized adults for empirical treatment of infection. Although has been hypothesized cause acute kidney injury cefepime neurological dysfunction, their comparative safety not evaluated in a randomized clinical trial. Objective To determine whether the choice between affects risks or dysfunction. Design, Setting, Participants The Antibiotic Choice on Renal Outcomes (ACORN) trial compared vs whom clinician...
Abstract Altered sensory processing is observed in many children with autism spectrum disorder (ASD), growing evidence that these impairments extend to the integration of information across different senses (that is, multisensory function). The serotonin system has an important role development and function, alterations serotonergic signaling have been suggested a ASD. A gain-of-function coding variant transporter (SERT) associates aversion humans, when expressed mice produces traits...
Circadian photoperiod, or day length, changes with the seasons and influences behavior to allow animals adapt their environment. Photoperiod is also associated seasonal rhythms of affective state, as evidenced by seasonality several neuropsychiatric disorders. Interestingly, tends be more prevalent in women for disorders such major depressive disorder bipolar (BD). However, underlying neurobiological processes contributing sex-linked behaviors are largely unknown. Mesolimbic dopamine input...
Patients diagnosed with end-stage liver disease (ESLD) often struggle a heavy symptom burden that compromises their quality of life. Introduction specialty palliative care (PC) may help address these issues but is underutilized in ESLD. This study aimed to assess the performance surprise question (SQ) this population as potential screen identify patients life expectancy less than 12 months. A retrospective cohort analysis was performed. In previous (COMPASS Trial, NCT03022630), attending...
Patch-clamp and multi-electrode array electrophysiology techniques are used to measure dynamic functional properties of neurons. Whole-cell cell-attached patch-clamp recordings in brain slices can be performed voltage-clamp current-clamp configuration reveal cell-type-specific synaptic cellular parameters governing neurotransmission. Multi-electrode provide spike activity from multiple neurons, enabling larger sample sizes, long-term recordings. We our guide preparing acute rodent with...
Abstract Background Robotic-assisted bronchoscopy has recently emerged as an alternative to electromagnetic navigational for the evaluation of peripheral pulmonary lesions. While robotic-assisted is proposed have several advantages, such easier learning curve, it unclear if comparable diagnostic utility bronchoscopy. Methods R obotic versus E lectromagnetic L es I on A ssessme NT (RELIANT) investigator-initiated, single-center, open label, noninferiority, cluster randomized controlled trial...
Human psychophysical and animal behavioral studies have illustrated the benefits that can be conferred from having information available multiple senses. Given central role of multisensory integration for perceptual cognitive function, it is important to design paradigms models provide mechanistic insights into neural bases these processes. Prior focused on large mammals, yet mouse offers a host advantages, most importantly wealth genetic manipulations relevant human disease. To begin employ...
Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, age, sex have been linked to seasonality in neuropsychiatric disorders, as seen Seasonal Affective Disorder, Major Depressive Bipolar Disorder. The nucleus accumbens key locus for regulation of motivated behaviors disorders. Using periadolescent young adult male female mice, here we assessed photoperiod's...
Abstract When the ancestors of modern Eurasians migrated out Africa and interbred with Eurasian archaic hominins, namely, Neanderthals Denisovans, DNA ancestry integrated into genomes anatomically humans. This process potentially accelerated adaptation to environmental factors, including reduced ultraviolet radiation increased variation in seasonal dynamics. However, whether these groups differed substantially circadian biology introgression adaptively contributed human chronotypes remain...
Abstract Photoperiod or the duration of daylight has been implicated as a risk factor in development mood disorders. The dopamine and serotonin systems are impacted by photoperiod consistently associated with affective Hence, we evaluated, at multiple stages postnatal development, expression key dopaminergic ( TH ) serotonergic Tph2 , SERT Pet-1 genes, midbrain monoamine content mice raised under control Equinox (LD 12:12), Short winter-like 8:16), Long summer-like 16:8) photoperiods....
Early life stimuli during critical developmental time frames have been linked to increased risk for neurodevelopmental disorders later in life. The serotonergic system of the brain is implicated mood and impacted by duration daylight, or photoperiod. Here we sought investigate sensitive periods prenatal postnatal development photoperiodic programming DRN serotonin neurons, midbrain metabolite levels along with affective behaviors adolescence (P30) adulthood (P50). To address these questions...
When the ancestors of modern Eurasians migrated out Africa and interbred with Eurasian archaic hominins, namely Neanderthals Denisovans, DNA ancestry integrated into genomes anatomically humans. This process potentially accelerated adaptation to environmental factors, including reduced ultra-violet radiation increased variation in seasonal dynamics. However, whether these groups differed substantially circadian biology, introgression adaptively contributed human chronotypes remains unknown.
Introduction Antibiotics are time-critical in the management of sepsis. When infectious organisms unknown, patients treated with empiric antibiotics to include coverage for gram-negative organisms, such as antipseudomonal cephalosporins and penicillins. However, observational studies, some (eg, cefepime) associated neurologic dysfunction while most common penicillin (piperacillin–tazobactam) is acute kidney injury (AKI). No randomised control trials have compared these regimens. This...
<title>Abstract</title> <bold>Background: </bold>Vancomycin, an antibiotic with activity against Methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP) despite the fact that MRSA rarely implicated CAP. Conducting polymerase chain reaction (PCR) testing on nasal swabs to identify presence of colonization has been proposed as antimicrobial stewardship intervention reduce use vancomycin. Observational studies have...
Abstract Background Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP) despite the fact that MRSA rarely implicated CAP. Conducting polymerase chain reaction (PCR) testing on nasal swabs to identify presence of colonization has been proposed as antimicrobial stewardship intervention reduce use vancomycin. Observational studies have shown reductions vancomycin...
Abstract • Background : Robotic assisted bronchoscopy has recently emerged as an alternative to electromagnetic navigational for the evaluation of peripheral pulmonary lesions. While robotic is proposed have several advantages, such easier learning curve, it unclear if comparable diagnostic utility bronchoscopy. Methods R obotic versus E lectromagnetic Bronchoscopy Pulmonary L es I on A ssessme NT (RELIANT) investigator-initiated, single-center, open label, noninferiority, cluster randomized...
While speech perception is thought of as an auditory-first process, it clear that integrating visual has dramatic behavioral impacts. This audiovisual integration impaired in children with autism. We investigated the role temporal processing on integration. measured binding window (TBW), a probabilistic construct reflecting interval time within which two sensory signals may be perceptually bound, and related this to McGurk Effect, measure Three age groups participants, 6-9, 10-13, 14-18yo...
A strong factor influencing multisensory integration is the temporal relationship between sensory inputs that are combined. Individuals with Autism Spectrum Disorders (ASD) exhibit both atypical and processing deficits relative to their typically developing (TD) peers. series of behavioral fMRI studies from our lab have focused on link these two processes. Using speech non-speech stimuli parametrically varied relationships auditory visual components, we showed indeed altered in ASD, largest...