A5025817533- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
- Pharmacovigilance and Adverse Drug Reactions
- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Studies on Chitinases and Chitosanases
- Cellular transport and secretion
- Intensive Care Unit Cognitive Disorders
- Pneumothorax, Barotrauma, Emphysema
- Substance Abuse Treatment and Outcomes
- Protease and Inhibitor Mechanisms
- Respiratory Support and Mechanisms
- Opioid Use Disorder Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological disorders and treatments
- Anesthesia and Pain Management
- Invertebrate Immune Response Mechanisms
- Enhanced Recovery After Surgery
- Glycosylation and Glycoproteins Research
- Genetic Neurodegenerative Diseases
- Pain Management and Opioid Use
- Prenatal Substance Exposure Effects
- Hereditary Neurological Disorders
- Lysosomal Storage Disorders Research
- Clinical practice guidelines implementation
Vanderbilt University Medical Center
2019-2025
META Group
2025
Analysis Group (United States)
2025
Vanderbilt University
2013-2024
Cytovale (United States)
2023
Vanderbilt Psychiatric Hospital
2021
John F. Kennedy Center for the Performing Arts
2013-2015
University of Tennessee at Knoxville
2009-2015
Importance Cefepime and piperacillin-tazobactam are commonly administered to hospitalized adults for empirical treatment of infection. Although has been hypothesized cause acute kidney injury cefepime neurological dysfunction, their comparative safety not evaluated in a randomized clinical trial. Objective To determine whether the choice between affects risks or dysfunction. Design, Setting, Participants The Antibiotic Choice on Renal Outcomes (ACORN) trial compared vs whom clinician...
<h3>Importance</h3> Awake prone positioning may improve hypoxemia among patients with COVID-19, but whether it is associated improved clinical outcomes remains unknown. <h3>Objective</h3> To determine the recommendation of awake COVID-19–related who have not received mechanical ventilation. <h3>Design, Setting, and Participants</h3> This pragmatic nonrandomized controlled trial was conducted at 2 academic medical centers (Vanderbilt University Medical Center NorthShore HealthSystem) during...
Importance The impact of awake prone positioning (APP) on clinical outcomes in patients with COVID-19 and acute hypoxemic respiratory failure (AHRF) remains uncertain. Objective To assess the association APP improved among AHRF, to identify potential effect modifiers. Data Sources PubMed, Embase, Cochrane Library, ClinicalTrials.gov were searched through August 1, 2024. Study Selection Randomized trials (RCTs) examining adults AHRF that reported intubation rate or mortality included....
A three base-pair deletion in the widely expressed TOR1A gene causes childhood onset, neurological disease of DYT1 dystonia. Mouse Tor1a knockout also specifically affects developing nervous system. However, both cases, basis neuronal tissue specificity is unknown. TorsinA one four predicted mammalian torsin ATPases associated with assorted cellular activities (AAA+) proteins, raising possibility that expression a functionally homologous compensates for torsinA loss non-neuronal tissues. We...
Different models of learning health systems are emerging. At Vanderbilt University Medical Center, the Learning Health Care System (LHS) Platform was established with goal creating generalizable knowledge. This differentiates LHS from other efforts that have adopted a quality improvement paradigm. By supporting pragmatic trials at intersection research, operations, and clinical care, designed to yield evidence for advancing content processes care through carefully designed, rigorous study....
TorsinA (also known as torsin-1A) is a membrane-embedded AAA+ ATPase that has an important role in the nuclear envelope lumen. However, most torsinA localized peripheral endoplasmic reticulum (ER) lumen where it slow mobility incompatible with free equilibration between ER subdomains. We now find nuclear-envelope-localized present on inner membrane (INM) and ask how reaches this subdomain. The system contains two transmembrane proteins, LAP1 LULL1 TOR1AIP1 TOR1AIP2, respectively), reversibly...
Balanced crystalloids may improve outcomes compared with saline for some critically ill adults. Lower tonicity of balanced could worsen cerebral edema in patients intracranial pathology. The effect versus on clinical traumatic brain injury (TBI) requires further study. We planned an a priori subgroup analysis TBI enrolled the pragmatic, cluster-randomized, multiple-crossover Isotonic Solutions and Major Adverse Renal Events Trial (SMART) (ClinicalTrials.gov: NCT02444988, NCT02547779)....
Introduction Patients with suspected bacterial infection frequently receive empiric, broad-spectrum antibiotics prior to pathogen identification due the time required for bacteria grow in culture. Direct-from-blood diagnostics identifying presence or absence of and/or resistance genes from whole blood samples within hours collection could enable earlier antibiotic optimisation patients have infections. However, few randomised trials evaluated effect using direct-from-blood testing on...
Synaptogenesis requires orchestrated intercellular communication between synaptic partners, with trans-synaptic signals necessarily traversing the extracellular synaptomatrix separating presynaptic and postsynaptic cells. Extracellular matrix metalloproteinases (Mmps) regulated by secreted tissue inhibitors of (Timps), cleave membrane-associated targets to sculpt environment modulate signaling. Here, we test roles Mmp at neuromuscular junction (NMJ) model synapse in reductionist Drosophila...
Neural development requires N-glycosylation regulation of intercellular signaling, but the requirements in synaptogenesis have not been well tested. All complex and hybrid MGAT1 (UDP-GlcNAc:α-3-D-mannoside-β1,2-N-acetylglucosaminyl-transferase I) function, Mgat1 nulls are most compromised condition that survive long enough to permit studies. At Drosophila neuromuscular junction (NMJ), mutants display selective loss lectin-defined carbohydrates extracellular synaptomatrix, an accompanying...
ABSTRACT Congenital disorders of glycosylation (CDGs) constitute a rapidly growing family human diseases resulting from heritable mutations in genes driving the production and modification glycoproteins. The symptomatic hypoglycosylation causes multisystemic defects that include severe neurological impairments, revealing particularly critical requirement for tightly regulated nervous system. most common CDG, CDG-Ia (PMM2-CDG), arises phosphomannomutase type 2 (PMM2) mutations. Here, we...
Matrix metalloproteinase (MMP) functions modulate synapse formation and activity-dependent plasticity. Aberrant MMP activity is implicated in fragile X syndrome (FXS), a disease caused by the loss of RNA-binding protein FMRP characterized neurological dysfunction intellectual disability. Gene expression studies Drosophila suggest that Mmps cooperate with heparan sulfate proteoglycan (HSPG) glypican co-receptor Dally-like (Dlp) to restrict trans-synaptic Wnt signaling synaptogenic defects fly...
Co-located bridge clinics aim to facilitate a timely transition outpatient care for inpatients with opioid use disorder (OUD); however, their effect on hospital length of stay (LOS) and postdischarge outcomes remains unclear.
Effective methods for engaging clinicians in continuing education learning-based practice improvement remain unknown.To determine whether a smartphone-based app using spaced with retrieval is an effective method to increase evidence-based practice.A prospective, unblinded, single-center, crossover randomized clinical trial was conducted at single academic medical center from January 6 April 24, 2020. Vanderbilt University Medical Center prescribing intravenous fluids were invited participate...
Synaptogenesis requires orchestrated intercellular communication between synaptic partners, with trans-synaptic signals necessarily traversing the extracellular synaptomatrix separating presynaptic and postsynaptic cells. Extracellular matrix metalloproteinases (Mmps) regulated by secreted tissue inhibitors of (Timps), cleave membrane-associated targets to sculpt environment modulate signaling. Here, we test roles Mmp at neuromuscular junction (NMJ) model synapse in reductionist Drosophila...
Problem In an ideal learning health care system (LHS), clinicians learn from what they do and learn, closing the evidence-to-practice gap. operationalizing LHS, great strides have been made in knowledge generation. Yet, considerable challenges remain to broad uptake of identified best practices. To bridge gap generating actionable applying that clinical practice, ultimately improving outcomes, new information must be disseminated implemented by frontline clinicians. date, dissemination this...
Patients with substance use disorders are overrepresented among general hospital inpatients, and their admissions associated longer lengths of stay increased readmission rates. Amid the national opioid crisis, attention has been given to integration addiction routine medical care in order better engage such patients minimize fragmentation care. General consultation services transitional, hospital-based "bridge" clinics have emerged as potential solutions. We designed Bridging Recovery...
Introduction Antibiotics are time-critical in the management of sepsis. When infectious organisms unknown, patients treated with empiric antibiotics to include coverage for gram-negative organisms, such as antipseudomonal cephalosporins and penicillins. However, observational studies, some (eg, cefepime) associated neurologic dysfunction while most common penicillin (piperacillin–tazobactam) is acute kidney injury (AKI). No randomised control trials have compared these regimens. This...