A5100327109- Statistical Methods and Inference
- Heart Failure Treatment and Management
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Emergency and Acute Care Studies
- Cerebrospinal fluid and hydrocephalus
- Advanced Causal Inference Techniques
- Cardiac Arrest and Resuscitation
- Dementia and Cognitive Impairment Research
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Sepsis Diagnosis and Treatment
- Dysphagia Assessment and Management
- Epigenetics and DNA Methylation
- Advanced MRI Techniques and Applications
- Insurance, Mortality, Demography, Risk Management
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Genetic Associations and Epidemiology
- Spinal Dysraphism and Malformations
- Cardiovascular Health and Disease Prevention
- Fetal and Pediatric Neurological Disorders
- Bayesian Methods and Mixture Models
- Scoliosis diagnosis and treatment
Vanderbilt University Medical Center
2017-2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
Anqing Normal University
2024
Shandong Normal University
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Soochow University
2023
Vanderbilt University
2011-2022
Xinjiang Normal University
2021
Saline (0.9% sodium chloride), the fluid most commonly used to treat diabetic ketoacidosis (DKA), can cause hyperchloremic metabolic acidosis. Balanced crystalloids, an alternative class of fluids for volume expansion, do not acidosis and, therefore, may lead faster resolution DKA than saline.To compare clinical effects balanced crystalloids with saline acute treatment adults DKA.This study was a subgroup analysis in 2 previously reported companion trials-Saline Against Lactated Ringer's or...
Cognitive-control theories assume that the experience of response conflict can trigger control adjustments. However, while some approaches focus on adjustments impact selection present (in trial N), other in next upcoming (N + 1). We aimed to trace over time by quantifying cortical noise means fitting oscillations and one f algorithm, a measure aperiodic activity. As predicted, trials increased exponent large sample 171 healthy adults, thus indicating reduction. While this adjustment was...
Abstract Objectives Blood culture contamination is a common problem in the emergency department ( ED ) that leads to unnecessary patient morbidity and health care costs. The study objective was develop evaluate effectiveness of quality improvement QI intervention for reducing blood an . Methods authors developed reduce then evaluated its prospective interrupted times series study. involved changing technique specimen collection from traditional clean procedure new sterile procedure, with...
Longitudinal data frequently occur in many studies, such as longitudinal follow-up studies. To develop statistical methods and theory for the analysis of these data, independent or noninformative observation censoring times are typically assumed, which naturally leads to inference procedures conditional on times. But situations this may not be true realistic; that is, responses correlated with well This article considers where correlations exist proposes a joint modeling approach uses some...
Abstract Background Heart failure is a major public health concern, affecting 6.7 million Americans. An estimated 16% of emergency department (ED) patients with acute heart (AHF) are discharged home. Our Get the Guidelines in Emergency Department Patients Failure (GUIDED-HF) toolkit aims to improve AHF self-care and facilitate safer transitions care for these patients. We describe implementation barriers facilitators, selection refinement strategies, future GUIDED-HF implementation. Methods...
Background ST-segment elevation myocardial infarction (STEMI) guidelines recommend screening arriving emergency department (ED) patients for an early ECG in those with symptoms concerning ischemia. Process measures target median door-to-ECG (D2E) time of 10 minutes. Methods and Results This 3-year descriptive retrospective cohort study, including 676 ED-diagnosed STEMI from geographically diverse facilities across the United States, examines alternative approach to quantifying performance:...
Summary Large observational databases derived from disease registries and retrospective cohort studies have proven very useful for the study of health services utilization. However, use large may introduce computational difficulties, particularly when event interest is recurrent. In such settings, grouping recurrent data into prespecified intervals leads to a flexible rate model reduction that remedies issues. We propose possibly stratified marginal proportional rates with piecewise‐constant...
// Qingbin Zhao 1 , Shudan Liao 2 Huiyi Wei Dandan Liu 3 Jingjie Li 4,5 Xiyang Zhang 5 Mengdan Yan and Tianbo Jin Department of Geratology, The First Affiliated Hospital Xi’an Jiaotong University, Xi’an, Shaanxi, China Cardiology, Center Hospital, Endocrinology, 4 Key Laboratory Resource Biology Biotechnology in Western (Northwest University), Ministry Education, Tiangen Precision Medical Institute, Correspondence to: Zhao, email: Keywords : coronary heart disease; single...
Summary Identification of novel biomarkers for risk assessment is important both effective disease prevention and optimal treatment recommendation. Discovery relies on the precious yet limited resource stored biological samples from large prospective cohort studies. Case‐cohort sampling design provides a cost‐effective tool in context biomarker evaluation, especially when clinical condition interest rare. Existing statistical methods focus making efficient inference relative hazard...
To determine whether baseline aortic stiffness, measured by pulse wave velocity (PWV), relates to longitudinal cerebral gray or white matter changes among older adults. Baseline cardiac magnetic resonance imaging will be used assess PWV while brain and hyperintensity (WMH) volumes at baseline, 18 months, 3 years, 5 7 years. Approach Results: Aortic (m/s) was quantified from resonance. Multimodal 3T included
In this paper, we consider the problem of testing significance covariates in a nonparametric regression model. We propose to use some bootstrap procedures better approximate finite sample distribution test statistics. establish asymptotic validity proposed procedures. Simulation results show that tests successfully overcome size distortions based on critical values obtained from null distributions.
Abstract Composite endpoints can encode multiple pieces of information and are increasingly adopted in clinical trials. Advocacy for using composite began decades ago cardiovascular trials, leading to incorporation patient-oriented outcomes consideration a hierarchical ranking system. The use coronavirus disease (COVID-19) trials has evolved similarly. We conducted literature review investigate the acute heart failure COVID-19 results showed more frequent ordinal which might be driven by...
Background: Delayed intervention for ST-segment elevation myocardial infarction (STEMI) is associated with higher mortality. The association of door-to-ECG (D2E) clinical outcomes has not been directly explored in a contemporary US-based population. Methods: This was three-year, 10-center, retrospective cohort study ED-diagnosed patients STEMI comparing mortality between those who received timely (<10 min) vs. untimely (>10 diagnostic ECG. Among survivors, we left ventricular ejection...
Summary In this article, we propose a positive stable shared frailty Cox model for clustered failure time data where the distribution varies with cluster-level covariates. The proposed accounts covariate-dependent intracluster correlation and permits both conditional marginal inferences. We obtain inference directly from model, then use stratified Cox-type pseudo-partial likelihood approach to estimate regression coefficient parameter. estimators are consistent asymptotically normal...
Abstract Aims This study aimed to assess short‐term outcomes among emergency department (ED) patients with acute heart failure (AHF) by preserved (≥50%) vs. reduced (<50%) ejection fraction (EF). Methods and results We conducted a retrospective, multicentre of adult ED AHF from 2017 2018 in an integrated healthcare system 21 hospitals. Among known EF, our primary outcome was 30 day all‐cause mortality, comparing EF (HFpEF) (HFrEF), adjusted for risk factors. ran separate multivariate...
Background: We conducted a secondary analysis of changes in the Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 over 30 days randomized trial self-care coaching versus structured usual care patients with acute heart failure who were discharged from emergency department. Methods: Patients 15 departments completed KCCQ-12 at department discharge and days. compared change scores between intervention arms, adjusted for enrollment demographic characteristics. used linear regression to describe...
Abstract Objective From the perspective of percutaneous coronary intervention (PCI) centers, locations ST‐segment elevation myocardial infarction (STEMI) diagnosis can include a referring facility, emergency medical services (EMS) transporting to PCI center, or center's department (ED). This challenges use door‐to‐balloon‐time as primary evaluative measure STEMI treatment pathways. Our objective was identify opportunities improve care by quantifying differences in timeliness mobilization...