A5037247154- Medication Adherence and Compliance
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Inflammatory Bowel Disease
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Acute Lymphoblastic Leukemia research
- HIV/AIDS Research and Interventions
- Adolescent and Pediatric Healthcare
- Multiple Sclerosis Research Studies
- Economic and Financial Impacts of Cancer
- HIV, Drug Use, Sexual Risk
- Chronic Lymphocytic Leukemia Research
- Microscopic Colitis
- Epilepsy research and treatment
- Cannabis and Cannabinoid Research
- Biosimilars and Bioanalytical Methods
- Hepatitis B Virus Studies
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Safe Handling of Antineoplastic Drugs
- Healthcare Policy and Management
- Hemoglobinopathies and Related Disorders
Vanderbilt University Medical Center
2017-2025
Vanderbilt Health
2022-2025
Lipscomb University
2021
Muhimbili Orthopaedic Institute
2021
University of Nebraska Medical Center
2019
Florida College
2018-2019
University of Florida
2018-2019
Austin College
2018-2019
Texas College
2018-2019
American Medical Research
2018-2019
Estimating medication adherence through the use of pharmacy claims-based calculations such as possession ratio (MPR) and proportion days covered (PDC) plays a significant role in specialty practice. Although MPR PDC are frequently used clinical practice, calculation methodologies vary, making meaningful comparisons rates difficult. In addition, increasingly by insurance companies, pharmacies, accrediting bodies, drug manufacturers to demonstrate quality differences or benefit across...
<h3>Importance</h3> Awake prone positioning may improve hypoxemia among patients with COVID-19, but whether it is associated improved clinical outcomes remains unknown. <h3>Objective</h3> To determine the recommendation of awake COVID-19–related who have not received mechanical ventilation. <h3>Design, Setting, and Participants</h3> This pragmatic nonrandomized controlled trial was conducted at 2 academic medical centers (Vanderbilt University Medical Center NorthShore HealthSystem) during...
For high-price drugs, Medicare Part D beneficiaries who do not receive a low-income subsidy must pay percentage of the drug’s price for each medication fill. Without that subsidy, which lowers out-of-pocket spending, typically hundreds or thousands dollars single We estimated proportion in fee-for-service Medicare, with and without initiate treatment (that is, fill new prescription) drugs newly prescribed four conditions. Examining 17,076 prescriptions issued between 2012 2018 from eleven...
Medication adherence plays a significant role in specialty pharmacy practice and depends on numerous factors.1 The 2 most common metrics using prescription claims are proportion of days covered (PDC) medication possession ratio (MPR). Neither accounts for clinically appropriate gaps therapy nor confirms the is administered, and, despite similar data, these do not regularly provide equivalent results. MPR PDC results often used to distinguish higher-performing pharmacies can have impact...
Phosphodiesterase-5 inhibitors (PDE-5I) have demonstrated improvement in disease symptoms and quality of life for patients with pulmonary arterial hypertension (PAH). Despite these benefits, reported adherence to PDE-5I therapy is sub-optimal. Clinical pharmacists at an integrated practice site are a unique position mitigate barriers related PAH including medication costs. The primary objective this study was assess within care model academic institution. secondary the impact out-of-pocket...
Balanced crystalloids may improve outcomes compared with saline for some critically ill adults. Lower tonicity of balanced could worsen cerebral edema in patients intracranial pathology. The effect versus on clinical traumatic brain injury (TBI) requires further study. We planned an a priori subgroup analysis TBI enrolled the pragmatic, cluster-randomized, multiple-crossover Isotonic Solutions and Major Adverse Renal Events Trial (SMART) (ClinicalTrials.gov: NCT02444988, NCT02547779)....
Many payers and pharmacy benefit managers (PBMs) use step therapy requirements formulary alternatives to reduce prescription spending. The clinical utility ultimate outcomes for patients participating in these programs is an area of needed research. To evaluate medication time access required a or alternative after being prescribed specialty psoriasis (PsO) atopic dermatitis (AD). A single-center, retrospective review data collected from electronic health records the patient management...
Oral oncolytic therapy for the management of chronic lymphocytic leukemia (CLL) or small (SLL), such as ibrutinib, acalabrutinib, and venetoclax, have vastly changed CLL treatment. Although effective, adverse effects these agents remain challenging. Pharmacists an important role in managing oral chemotherapy, educating patients, intervening to reduce effects. To evaluate medication utilization patterns (adherence, persistence, discontinuation, switching therapy) pharmacists' patients...
Abstract Disclaimer In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time. Purpose To evaluate implementation electronic early treatment assessment monitoring (eTEAM) questionnaire within health...
Background Deutetrabenazine, a vesicular monoamine transporter 2 inhibitor, is one of few treatment options available for Huntington's disease (HD) chorea. There limited data describing clinical experience with deutetrabenazine doses >48 mg daily. Objective Describe outcomes Methods A dual site retrospective cohort study patients on titrated to mg/day HD chorea from April 2017 through December 2021 was conducted. Patients using concomitant strong CYP2D6 inhibitors at time initiation,...
Introduction: Combination therapy with protein kinase B-raf (BRAF) inhibitor, encorafenib, and mitogen-activated extracellular (MEK) binimetinib, is associated adverse events (AEs) that can lead to changes early in treatment. This study assessed the impact of pharmacist tailored monitoring on during first 90 days after initiation. Methods: single center, pre-post intervention included adult patients initiating encorafenib binimetinib for unresectable or metastatic melanoma, prescriptions...
Abstract Background In inflammatory bowel disease (IBD), including Crohn’s (CD) and ulcerative colitis (UC), nonadherence to biologic therapy increases risk of flare. The aim this study was identify factors for nonadherence. Methods This a single-center retrospective evaluating patients with IBD treated at tertiary care center prescribed self-injectable using the center’s specialty pharmacy. Adherence defined medication possession ratio (MPR). Nonadherence as MPR &lt;0.86. Results Four...
Abstract Purpose Results of the first ASHP national survey clinical services provided by health-system specialty pharmacies (HSSPs) are presented. Methods A questionnaire was developed 26 HSSP contacts after reviewing available literature on role and HSSPs. After pilot cognitive testing resulting in a final 119 questions, convenience sample 441 leaders HSSPs contacted using email invited to participate survey. The response rate 29%. Almost half respondents (48%) had offered pharmacy for 7...
Disease-modifying therapy (DMT) delays disease progression and improves quality of life for patients with multiple sclerosis (MS), but adherence to DMT is often suboptimal. Vanderbilt Specialty Pharmacy (VSP) embeds pharmacists within an outpatient MS clinic provide medication management address barriers adherence.We evaluated rates predictors among at integrated specialty pharmacy.We included who filled ≥3 prescriptions from VSP during the study period. Adherence was defined as possession...
Abstract Background The US National Viral Hepatitis Action Plan depends on additional providers to expand hepatitis C virus (HCV) treatment capacity in order achieve elimination goals. Clinical pharmacists manage and medication within interdisciplinary teams. study’s objective was determine sustained virologic response (SVR) rates for clinical pharmacist–delivered HCV therapy an open medical system. Methods Investigators conducted a multicenter retrospective cohort study of patients...
Abstract Purpose This report describes a health-system pharmacy’s response to natural disaster while staff members simultaneously prepared for the coronavirus disease 2019 (COVID-19) pandemic. By detailing our experience, we hope help other institutions that are current facing or could encounter similar crises. Summary In early March 2020, tornado destroyed health system’s warehouse storage of most clinical supplies, including personal protective equipment and fluids. The pharmacy purchasing...
Co-located bridge clinics aim to facilitate a timely transition outpatient care for inpatients with opioid use disorder (OUD); however, their effect on hospital length of stay (LOS) and postdischarge outcomes remains unclear.
BACKGROUND: Disease-modifying anti-rheumatic drugs (DMARDs) improve symptoms and delay progression of rheumatoid arthritis (RA), but adherence is often sub-optimal many patients change medication (either "switching" to a with different mechanism action or "cycling" the same action) during first year therapy. Some integrated health-system specialty pharmacies embed pharmacists in clinics help access adhere medication. OBJECTIVE: This study assessed DMARD switching, cycling, adherence,...
Specialty pharmacists monitor patients taking multiple sclerosis (MS) disease-modifying therapies (DMTs) to evaluate response therapy and intervene on adverse effects. These interventions have the potential avoid health care costs by discontinuing inappropriate avoiding downstream utilization.
Introduction/Objectives: Pre-exposure prophylaxis (PrEP) use in the southern United States is low despite its effectiveness preventing HIV acquisition and high regional prevalence. Our objectives were to assess PrEP knowledge, attitudes, prescribing practices among Tennessee primary care providers. Methods: We developed an anonymous cross-sectional electronic survey from March November 2019. Survey development was guided by Capability, Opportunity, Motivation, Behavior framework refined...