A5074591388- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- Mental Health and Patient Involvement
- HIV Research and Treatment
- Health Policy Implementation Science
- Antifungal resistance and susceptibility
- Homelessness and Social Issues
- Fungal Infections and Studies
- Sex work and related issues
- Pneumonia and Respiratory Infections
- Adolescent Sexual and Reproductive Health
- Mobile Health and mHealth Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Public Health Policies and Education
- Adolescent and Pediatric Healthcare
- Acute Kidney Injury Research
- Data-Driven Disease Surveillance
- Health Literacy and Information Accessibility
Vanderbilt University Medical Center
2016-2025
Vanderbilt University
2016-2025
Mbarara University of Science and Technology
2021
Vanderbilt Health
2015-2020
Office of Infectious Diseases
2012-2019
Tennessee Department of Health
2016-2019
Office of Readiness and Response
2016
Centers for Disease Control and Prevention
2016
National Center for Advancing Translational Sciences
2016
Council of State and Territorial Epidemiologists
2016
Background: Because implementation remains the biggest challenge to Ending HIV Epidemic in United States (EHE), since 2019, National Institutes of Health (NIH) has funded 248 supplements identify best practices for delivering evidence-based interventions. NIH also a coordination center [Implementation Science (IS) Coordination Initiative “ISCI”] and 9 consultation hubs (“Hubs”) provide technical assistance cross-project information sharing, measure harmonization, data synthesis. This article...
Persistent neutrophilic meningitis presents a diagnostic challenge, because the differential diagnosis is broad and includes atypical infectious causes. We describe case of persistent due to Aspergillus fumigatus in an immunocompetent man who had no evidence sinopulmonary or cutaneous disease. An epidural glucocorticoid injection was identified as potential route entry for this organism into central nervous system, reported state health department.
Elimination of tuberculosis (TB) disease in the US hinges on ability tests to detect individual risk developing inform prevention. The relative performance 3 available TB tests-the tuberculin skin test (TST) and 2 interferon-γ release assays (IGRAs; QuantiFERON-TB Gold In-Tube [QFT-GIT] SPOT.TB [TSPOT])-in predicting development remains unknown.
We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-alpha) inhibitors for rheumatologic disorders. Although TNF-alpha have been reported to increase the risk other infectious diseases, our knowledge, an association between anti-TNF-alpha drugs and has not previously described.
Background Lack of a gold standard for latent TB infection has precluded direct measurement test characteristics the tuberculin skin and interferon-γ release assays (QuantiFERON Gold In-Tube T-SPOT.TB). Objective We estimated sensitivity/specificity prevalence in prospective, US-based cohort 10 740 participants at high risk infection. Methods Bayesian class analysis was used to estimate among subgroups based on age, foreign birth outside USA HIV Results Latent varied from 4.0% foreign-born,...
HIV-1 infection leads to chronic inflammation and an increased risk of non-AIDS mortality. Our objective was determine whether AIDS-defining events (ADEs) were associated with overall cause-specific related mortality after antiretroviral therapy (ART) initiation.We included HIV treatment-naïve adults from the Antiretroviral Therapy Cohort Collaboration (ART-CC) who initiated ART 1996 2014. Causes death assigned using Coding Death in (CoDe) protocol. The adjusted hazard ratio (aHR) for among...
Abstract Introduction Extrapulmonary tuberculosis ( EPTB ) is difficult to confirm bacteriologically and requires specific diagnostic capacities. Diagnosis can be especially challenging in under‐resourced settings. We studied modalities clinical outcomes of compared pulmonary PTB among HIV ‐positive adults antiretroviral therapy ART programmes low‐ middle‐income countries LMIC ). Methods collected data from TB patients (≥16 years) 22 participating the International Epidemiology Databases...
Abstract Background Tuberculosis (TB) elimination within the United States will require scaling up TB preventive services. Many public health departments offer care for latent tuberculosis infection (LTBI), although gaps in LTBI cascade are not well quantified. An understanding of these be required to design targeted interventions. Methods We conducted a cohort study through Epidemiologic Studies Consortium (TBESC) 15 local department (LHD) clinics across States. Data were abstracted on...
Abstract Introduction Since its global reemergence in 2022, monkeypox (mpox) has demonstrated increased incidence and severity among people with human immunodeficiency virus (HIV [PWH]). Predictors of mpox diagnosis, vaccination, outcomes PWH are limited. Methods We included primary care visits after 1 January 2022 at 9 US sites participating the Centers for AIDS Research Network Integrated Clinic Systems Network. identified diagnosed between June 31 May 2023, through a combination...
Prompt diagnosis and treatment of fungal meningitis are critical, but culture is insensitive. (1,3)-β-d-Glucan (BDG) testing FDA approved for serological invasive disease; however, BDG not cerebrospinal fluid (CSF), the appropriate cutoff value unknown. We aimed to validate diagnostic accuracy CSF measurements among patients exposed contaminated methylprednisolone acetate (MPA). A retrospective observational study was conducted at St. Joseph Mercy Hospital Vanderbilt University from November...
Management of tuberculosis (TB) is challenging in HIV/TB-coinfected children. The World Health Organization recommends nucleic acid amplification tests for TB diagnosis, a 4-drug regimen including ethambutol during intensive phase (IP) treatment, and initiation antiretroviral therapy (ART) within 8 weeks diagnosis. We investigated treatment outcomes by diagnostic modality, IP regimen, ART status.We conducted retrospective cohort study among children enrolled at the International Epidemiology...
The increased incidence of chronic diseases among people with HIV (PWH) is poised to increase the need for specialty care outside treatment settings. To reduce outcome disparities HIV-associated comorbidities in United States, it critical optimize access and quality underrepresented racial ethnic minority (URM) individuals HIV. We explored experiences URM other setting during their initial follow-up appointments. conducted qualitative interviews participants at three large academic medical...
National US data on the burden and risks for hepatitis C virus (HCV) infection in people with human immunodeficiency (HIV) during direct-acting antiviral (DAA) era are limited. These important to understand current progress guide future efforts toward HCV microelimination. We evaluated (1) prevalence (2011-2013, 2014-2017, 2018-2022) using a serial cross-sectional design (2) correlates viremia (2018-2022) adult HIV (PWH) within Centers AIDS Research Network of Integrated Clinic Systems...
Background People with HIV (PWH) have elevated cardiovascular risk. Underrepresented racial and ethnic groups in the southern United States are disproportionately affected, yet whether cardiology care for this at‐risk group improves blood pressure lipid control or prevents events is unknown. Methods Results We evaluated a cohort of PWH from underrepresented who received HIV‐related at 4 centers during 2015 to 2018 follow‐up through 2020. Primary outcomes were (<140/90 mm Hg) (low‐density...
Compared with the general public, people HIV (PWH) experience more psychological trauma and higher rates of post-traumatic stress disorder (PTSD), yet limited research explores how PWH may uniquely trauma. The primary goal this study was to investigate exposure typologies sequelae among inform screening interventions. Qualitative interviews were conducted a convenience sample 20 PTSD, receiving services from an urban, Tennessee-based Service Organization. Interview guides gain rich...
Background: Meaningful community engagement in research is critical yet challenging traditional academic models. To inform efforts, we characterized community–academic partnerships funded through the Ending HIV Epidemic (EHE) Initiative. Methods: From July to December 2023, and partner recipients of 2021 or 2022 EHE implementation science awards were invited independently complete an online survey assessing partnership experience, anticipated experienced levels engagement, throughout...
Programmatic data from the United States on tuberculosis (TB) recurrence are limited.
Objective Xpert MTB/RIF is recommended by the World Health Organization (WHO) as initial tuberculosis (TB) diagnostic test in individuals suspected of HIV-associated TB. We sought to evaluate field implementation among a cohort HIV/TB co-infected individuals, including availability, utilization and outcomes. Design Observational study (patient-level data) cross-sectional (site-level availability data). Methods Data were collected at 30 participating International epidemiologic Databases...
Objectives: Tennessee was 1 of 8 states that received funding from the Care and Prevention in United States Demonstration Project, which aimed to reduce HIV-related morbidity mortality among racial/ethnic sexual minority populations. The objective this study describe implementation a social network strategy (SNS) program, leverages personal connections networks, reach people with undiagnosed HIV infection for testing. We targeted young black men who have sex (MSM) at 3 agencies Memphis...
<h3>Importance</h3> Ehrlichiosis cases in the US have increased more than 8-fold since 2000. Up to 57% of patients with ehrlichiosis require hospitalization and 11% develop a life-threatening complication; however, risk factors for serious disease are not well documented. <h3>Objective</h3> To examine associated severe ehrlichiosis. <h3>Design, Setting, Participants</h3> An analytic cross-sectional study diagnosed by polymerase chain reaction (PCR) between January 1, 2007, December 31, 2017,...