A5049700288- Tuberculosis Research and Epidemiology
- Magnetic confinement fusion research
- Mycobacterium research and diagnosis
- Ionosphere and magnetosphere dynamics
- Solar and Space Plasma Dynamics
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced materials and composites
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Superconducting Materials and Applications
- Powder Metallurgy Techniques and Materials
- Neural Networks and Applications
- HIV Research and Treatment
- Electrical Contact Performance and Analysis
- Laser-Plasma Interactions and Diagnostics
- Injection Molding Process and Properties
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Intermetallics and Advanced Alloy Properties
- Antibiotics Pharmacokinetics and Efficacy
- Fusion materials and technologies
- Particle accelerators and beam dynamics
- Mechanical stress and fatigue analysis
University Hospitals of Cleveland
2009-2025
Case Western Reserve University
2016-2025
University School
2014-2025
MUJHU Research Collaboration
2012-2025
Specialty Materials (United States)
2025
CTS Corporation (United States)
2024
Johnson & Johnson (United States)
2024
Toshiba (United States)
2022-2023
Lawrence Livermore National Laboratory
2023
University of Pennsylvania
1997-2022
In toroidal systems with geodesic curvature an electrostatic acoustic mode occurs plasma motion in the magnetic surfaces, perpendicular to field. typical stellarators this should dominate ordinary sound waves associated along
Pulse coupled neural network (PCNN) models are described. The linking field modulation term is shown to be a universal feature of any biologically grounded dendritic model. Applications and implementations PCNNs reviewed. Application based variations simplifications summarized. PCNN image decomposition (factoring) model described in detail.
Previous work by Johnson and Greene on resistive instabilities is extended to finite-pressure configurations. The Mercier criterion for the stability of ideal magnetohydrodynamic interchange mode rederived, generalization earlier obtained, a relation between two noted. Conditions tearing instability are recovered with growth rate scaling resistivity in more complicated manner than η3/5. Nyquist techniques used show that favorable average curvature can convert into an overstable often stabilize it.
Infection with the human immunodeficiency virus (HIV) greatly increases risk of reactivation tuberculosis. We evaluated safety and efficacy three preventive-therapy regimens in a setting where exposure to tuberculosis is common.
Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.
Abstract Hydrogen peroxide decomposition rates were measured on five soils after incubation with and without added organic matter bentonite. The measurement was affected by soil type, addition of matter, bentonite drying the sample. two‐factor interactions × additive, bentonite, drying, additive highly significant. three‐factor interaction reaction rate greatly increased powdered milk but only partly lowered autoclaving.
Tuberculosis kills more people than any other infectious disease. Three pivotal trials testing 4-month regimens failed to meet non-inferiority margins; however, approximately four-fifths of participants were cured. Through a pooled analysis patient-level data with external validation, we identify populations eligible for treatment, define phenotypes that are hard treat and evaluate the impact adherence dosing strategy on outcomes. In 3,405 included in analyses, baseline smear grade 3+...
The effects of small electrical resistivity, viscosity, and thermal conductivity on hydromagnetic instabilities for diffuse linear pinch configurations are considered. For finite-pressure systems, higher order equations must be solved than in previous work that was applicable to stellarator or slab geometries. A careful treatment the problem matching perturbed solution across boundaries separate a resistive layer from outer regions clarifies relationship between ordinary obtained ideal...
Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis infection to pulmonary disease in humans remains limited. To define such mechanisms, we followed M. tuberculosis-infected adolescents longitudinally. Blood samples forty-four who ultimately developed (“progressors”) were compared with those 106 matched controls, remained healthy during two years follow up. We performed longitudinal whole blood transcriptomic analyses by RNA sequencing and plasma proteome...
Osteosarcoma is one of the most common bone cancers in children. Most patients with metastatic osteosarcoma die pulmonary disease and limited curative therapeutic options exist for such patients. We have previously shown that PD-1 limits efficacy CTL to mediate immune control K7M2 mouse model blockade PD-1/PD-L1 interactions can partially improve survival outcomes by enhancing function osteosarcoma-specific CTL. However, blockade-treated mice eventually succumb due selection PD-L1...
Immunological and clinical profiles were evaluated in 2 groups: human immunodeficiency virus (HIV)—uninfected HIV-infected patients, with newly diagnosed pulmonary tuberculosis (TB), tuberculin-skin-test—reactive healthy control subjects. HIV-uninfected patients TB also followed up longitudinally during after chemotherapy. At the time of diagnosis, purified protein derivative (PPD)—stimulated production interferon (IFN)—γ by peripheral blood mononuclear cells from was depressed, compared...
Moxifloxacin has promising preclinical activity against Mycobacterium tuberculosis, but not been evaluated in multidrug treatment of tuberculosis humans.To compare the impact moxifloxacin versus ethambutol, both combination with isoniazid, rifampin, and pyrazinamide, on sputum culture conversion at 2 mo as a measure potential sterilizing alternate induction regimens.Adults smear-positive pulmonary were randomized factorial design to receive (400 mg) ethambutol given 5 d/wk 3 (after wk daily...
The linking-field neural network model of Eckhorn et al. [Neural Comput. 2, 293–307 (1990)] was introduced to explain the experimentally observed synchronous activity among assemblies in cat cortex induced by feature-dependent visual activity. produces bursts pulses from neurons with similar activity, effectively grouping them phase and pulse frequency. It gives a basic new function: similarity. are obtained limit strong linking strengths. moderate-to-weak characterized few if any multiple...
Moxifloxacin has potent activity against Mycobacterium tuberculosis in vitro and a mouse model of antituberculosis (TB) chemotherapy, but data regarding its humans are limited.Our objective was to compare the antimicrobial safety moxifloxacin versus isoniazid during first 8 weeks combination therapy for pulmonary TB.Adults with sputum smear-positive TB were randomly assigned receive either 400 mg plus placebo, or 300 administered 5 days/week weeks, addition rifampin, pyrazinamide,...
Objective: Tumor necrosis factor (TNF), an important inflammatory mediator in tuberculosis, has been implicated causing accelerated HIV disease progression HIV-associated tuberculosis. However, TNF blockade, particularly by monoclonal antibody, associated with the reactivation of latent Mycobacterium tuberculosis infection impairment mycobacterial immunity. This phase 1 study examined safety, microbiology, immunology, and virology blockade using etanercept (soluble receptor, Enbrel) during...
Techniques for calculating hydromagnetic equilibria in toroidal systems which differ little from a uniform field are developed. The zeroth-order magnetic surfaces these appreciably concentric circular toroids. Care is taken to match onto reasonable external fields at the plasma boundary. Expressions various equilibrium properties including rotational transform, net current on each surface, and lines of force obtained. As an illustration theory it shown that application particular...
Application of resistive instability theory shows that toroidal effects can stabilize the tearing mode in devices like Princeton Large Torus. Contraction current channel is destabilizing. Finite fluid compressibility crucial to this phenomenon.
ABSTRACT We examined sputum bacterial loads in adults with newly diagnosed tuberculosis using quantitative culture and time-until-positive (DTP) BACTEC 460. Patients cavitary disease had higher CFU levels than those without cavities shorter DTPs. Within radiographic strata of moderately far advanced tuberculosis, counts were associated disease.
The objective of this study was to determine the population pharmacokinetic parameters levofloxacin, gatifloxacin, and moxifloxacin following multiple oral doses. Twenty-nine patients with tuberculosis at University Hospital in Vitória, Brazil, participated. Subjects received doses one drug (levofloxacin, 1,000 mg daily, or gatifloxacin moxifloxacin, 400 daily) as part a 7-day early bactericidal activity. Serum samples were collected over 24 h after fifth dose assayed using validated...
Journal Article Nucleotide sequence of Clostridium difficile toxin B gene Get access LA. Barroso, Barroso * Department Anaerobic Microbiology, Virginia Polytechnic Institute and State UniversityBlacksburg, VA 24061, USA To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar S.-Z. Wang, Wang C.J. Phelps, Phelps J.L Johnson, Johnson T.D. Wilkins Nucleic Acids Research, Volume 18, Issue 13, 11 July 1990, Page 4004,...
DNAs of type strains and representative members Actinomyces groups from the human periodontal flora other habitats were compared by using S1 nuclease procedure to determine their genetic relatedness. One rather common group flora, previously called "Actinomyces D08," is phenotypically distinct from, genetically unrelated to, described species. We propose name georgiae for this organism; strain ATCC 49285. Another israelii serotype II, which was found be A. (serotype I) species Actinomyces....