A5102870129- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Interprofessional Education and Collaboration
- HIV/AIDS Research and Interventions
Johns Hopkins University
2008-2022
Johns Hopkins Medicine
2013-2022
Vanderbilt University
2020
Vanderbilt University Medical Center
2020
Rush University
2019
Respiratory Health Association
2019
Baltimore City Health Department
2008
Charlottesville Medical Research
2008
Albemarle (United States)
2008
District of Columbia Department of Health
2008
The risk and timing of tuberculosis among recently exposed close contacts patients with infectious are not well established.
Elimination of tuberculosis (TB) disease in the US hinges on ability tests to detect individual risk developing inform prevention. The relative performance 3 available TB tests-the tuberculin skin test (TST) and 2 interferon-γ release assays (IGRAs; QuantiFERON-TB Gold In-Tube [QFT-GIT] SPOT.TB [TSPOT])-in predicting development remains unknown.
Abstract Background Predictors of latent tuberculosis infection (LTBI) among close contacts persons with infectious (TB) are incompletely understood, particularly the number exposure hours. Methods We prospectively enrolled adult patients culture-confirmed pulmonary TB and their at 9 health departments in United States Canada. Patients were interviewed screened for LTBI during contact investigations. Results was diagnosed 1390 (46%) 3040 contacts, including 624 (31%) 2027 US/Canadian-born...
Abstract Background Close contacts of persons with pulmonary tuberculosis (TB) have high rates TB disease. Methods We prospectively enrolled patients and their close at 9 US/Canadian sites. were interviewed to identify index patient, contact, exposure risk factors for TB. Contacts evaluated latent infection (LTBI) TB, the effectiveness LTBI treatment preventing contact was examined. Results Among 4490 contacts, multivariable age ≤5 years, birth, human immunodeficiency virus infection, skin...
BACKGROUND: Video directly observed therapy (vDOT) was introduced to increase flexibility and meet patient-specific needs for TB treatment. This study aimed assess the reach effectiveness of vDOT treatment under routine conditions in Alameda County, CA, USA, a busy, urban setting, from 2018 2020.METHODS: We prospectively evaluated routinely collected data estimate 1) (proportion patients initiated on vs. in-person DOT); 2) prescribed doses with verified administration by DOT).RESULTS: Among...
In-person directly observed therapy (DOT) is commonly used for tuberculosis (TB) treatment monitoring in the US, with increasing usage of video-DOT (vDOT). We evaluated impact COVID-19 on TB adherence, and utilization effectiveness vDOT. abstracted routinely collected data individuals treated disease Baltimore, Maryland between April 2019 2021. Our primary outcomes were to assess vDOT defined as proportion prescribed doses (7 days/week) verified by observation (in-person versus video-DOT),...
We examined cytokine immune response profiles among contacts to tuberculosis patients identify immunologic and epidemiologic correlates of tuberculosis.We prospectively enrolled 1272 culture-confirmed pulmonary at 9 United States Canadian sites. Epidemiologic characteristics were recorded. Blood was collected stimulated with Mycobacterium culture filtrate protein, tumor necrosis factor (TNF-α), interferon gamma (IFN-γ), interleukin 10 (IL-10) concentrations determined using immunoassays.Of...
Background In-person directly observed therapy (DOT) is standard of care for tuberculosis (TB) treatment adherence monitoring in the US, with increasing use video-DOT (vDOT). In Minneapolis, vDOT became available 2019. Objective this paper, we aimed to evaluate and effectiveness a program setting, including comparison verified among those receiving in-person DOT. We also sought understand impact COVID-19 on TB technology adoption. Methods abstracted routinely collected data individuals MN,...
Determining the human immunodeficiency virus (HIV) status of tuberculosis (TB) patients and contacts is important. Despite existing guidelines, not all are tested, testing rarely performed.In a study conducted at nine US/Canadian sites, we introduced formal procedures for offering HIV to TB contacts. Data were collected via interviews medical record review. Characteristics associated with accepting examined.Of 651 patients, 601 (92%) offered testing, 511 (85%) accepted, 51 (10%)...
Background: Healthcare workers (HCWs) undergo annual testing for latent tuberculosis infection (LTBI).Objective: Compare acceptability of tuberculin skin test (TST) and interferon-gamma release assay (IGRA) among HCWs.Methods: HCWs at four medical centers in the US were administered an questionnaire including a brief objective description both tests eliciting attitudes regarding TST IGRAs, confidence results, likelihood taking LTBI treatment.Results: Of 406 participants, 75% had never heard...
Incorrect CME Quiz Question in: Association of Cholesteryl Ester Transfer Protein Genotypes With CETP Mass and Activity, Lipid Levels, Coronary Risk
Abstract BACKGROUND In-person directly observed therapy (DOT) is commonly used for tuberculosis (TB) treatment monitoring in the US, with increasing usage of video-DOT (vDOT). We evaluated impact COVID-19 on TB adherence, and utilization effectiveness vDOT. METHODS abstracted routinely collected data individuals treated disease Baltimore, Maryland between April 2019 2021. Our primary outcomes were to assess vDOT defined as proportion prescribed doses (7 days/week) verified by observation...
<sec> <title>BACKGROUND</title> In-person directly observed therapy (DOT) is commonly used for tuberculosis (TB) treatment adherence monitoring in the US, with increasing usage of video-DOT (vDOT). In Minneapolis, vDOT became available 2019. </sec> <title>OBJECTIVE</title> We aimed to evaluate programmatic utilization and effectiveness over time, impact COVID-19 on TB technology adoption. <title>METHODS</title> abstracted routinely collected data individuals receiving disease MN between...