A5101417066- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Forensic and Genetic Research
- DNA Repair Mechanisms
- Sulfur Compounds in Biology
- Pneumothorax, Barotrauma, Emphysema
- Sphingolipid Metabolism and Signaling
- Metal complexes synthesis and properties
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Transgenic Plants and Applications
- Respiratory Support and Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Redox biology and oxidative stress
- Cardiac Arrest and Resuscitation
- Glycosylation and Glycoproteins Research
- Lysosomal Storage Disorders Research
- Genomic variations and chromosomal abnormalities
- Statistical Methods in Clinical Trials
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- Meat and Animal Product Quality
- Plant Gene Expression Analysis
Wuhan Business University
2024-2025
Analysis Group (United States)
2025
META Group
2025
Southeast University
2024-2025
Vanderbilt University Medical Center
2024
American College of Surgeons
2024
Beijing Radiation Center
2024
Henan Provincial People's Hospital
2017-2024
Zhengzhou University
2017-2024
Temple University Hospital
2024
<h3>Importance</h3> Awake prone positioning may improve hypoxemia among patients with COVID-19, but whether it is associated improved clinical outcomes remains unknown. <h3>Objective</h3> To determine the recommendation of awake COVID-19–related who have not received mechanical ventilation. <h3>Design, Setting, and Participants</h3> This pragmatic nonrandomized controlled trial was conducted at 2 academic medical centers (Vanderbilt University Medical Center NorthShore HealthSystem) during...
Acute kidney injury (AKI) is a life-threatening health condition associated with increasing morbidity and mortality. Despite extensive research on the mechanisms underlying AKI, effective clinical tools for prediction treatment remain scarce. Oxidative stress mitochondrial damage play critical role in AKI dopamine D4 receptor (DRD4) has been confirmed to be oxidative stress. In this study, we hypothesized that DRD4 could attenuate through its antioxidative antiapoptotic effects. vivo, was...
Stroke, primarily ischemic (85%), results from inadequate blood supply and is worsened by ferroptosis, characterized free radical generation lipid peroxidation. Monitoring ferroptosis essential for understanding its mechanisms developing treatments. Glutathione (GSH) a key biomarker, but current probes are limited short excitation/emission wavelengths, small Stokes shifts, inability to monitor dynamic GSH changes at the cellular membrane, where plays crucial role. To address these issues, we...
Objective: Venglustat is a small-molecule inhibitor of glucosylceramide synthase (GCS), which reduces the synthesis (GL-1), key precursor for complex glycosphingolipids [1]. This inhibition anticipated to have significant therapeutic potential in variety disorders, including lysosomal storage diseases and other conditions linked elevated levels GL-1 or related glycosphingolipids. Using model-based approach, we characterized pharmacokinetic (PK) properties healthy subjects patients quantified...
Introduction: Model-informed drug development (MIDD) plays an important role in pharmacometrics by combining mathematical models with clinical [1]. Traditional methods such as Nonlinear Mixed Effects Modeling especially developed from NONMEM software have long been the gold standard for population PK analyses. However, of artificial intelligence (AI) presents a potential improvement predictive accuracy and computational efficiency [2]. In this study, we aim to benchmark popPK analysis...
Background Xuebijing (XBJ) injection has been used to treat sepsis. However, the effect and mechanism of XBJ in treatment septic acute kidney injury (AKI) is unknown. This study aimed explore therapeutic on AKI elucidate its possible mechanisms.
N6-methyladenosine (m6A) was the most abundant modification of mRNA and lncRNA in mammalian cells played an important role many biological processes. However, whether m6A associated with recurrent spontaneous abortion (RSA) its roles were still unclear. Methods: Methylated RNA immunoprecipitation sequencing (MeRIP-Seq) used to study global pattern RSAs controls. (RNA-Seq) level two groups. Real-time quantitative PCR (RT-qPCR) verify METTL3 ZBTB4. MeRIP-qPCR conducted test ZBTB4 In order...
Post-traumatic stress disorder (PTSD) refers to a chronic impairing psychiatric occurring after exposure the severe traumatic event. Studies have demonstrated that medicinal cannabis oil plays an important role in neuroprotection, but mechanism by which it exerts anti-PTSD effects remains unclear. The complex (CCS) simulating conditions of long voyage for 4 weeks was used establish PTSD mice model. After that, behavioral tests were evaluate PTSD-like behaviors mice. Mouse brain tissue index...
Low temperature affects the quality and yield of non-heading Chinese cabbage.C2H2-type zinc finger proteins (C2H2-ZFPs) play an important role in various environmental stresses. To date, functions C2H2-ZFPs cabbage are still uncharacterized. Here, 163 were identified using sequenced NHCC001 genome classified into nine subfamilies. Then characterization was comprehensively investigated. Synteny analysis suggested that these genes highly conserved during evolution, which may be related to...
Background: Etoposide is a cancer drug that induces strand breaks in cellular DNA by inhibiting topoisomerase II (topoII) religation of cleaved molecules.Although cleavage always produces II-linked double-strand (DSBs), the action etoposide also results single-strand (SSBs), since two strands are independently inhibited etoposide.In addition, recent studies indicate DSBs remain undetected unless removed to produce free DSBs.Methodology/Principal Findings: To examine etoposide-induced damage...
Abstract Background Desbuquois dysplasia (DBQD) was a rare autosomal recessive skeletal dysplasia. Calcium activated nucleotidase 1 ( CANT1 ) mutation identified as common pathogenic change for DBQD type and Kim variant but not 2. To our knowledge, all patients with currently found could be explained by mutations in the gene, gene might directly diagnosed 1. Results We have two novel (mut1: c.594G > A [p.Trp198*], mut2: c.734C T [p.Pro245Leu]) three children from family of Chinese origin...
Patients with asthma and chronic obstructive pulmonary disease rely on inhaler therapy to reduce progression exacerbation risk. admitted the hospital are at an increased risk for exacerbations readmission if their upon discharge is not aligned current guidelines and/or affordable.
Objective: To quantify health utilities of the Glasgow Outcome Scale-Extended (GOSE) states after actual Traumatic Brain Injury (TBI). Background: Recovery TBI is measured using GOSE, a validated clinical trial endpoint. A recent public survey quantified some GOSE hypothetical as worse than death. However, no exist for disability TBI. Methods: This national computer-adaptive followed EQUATOR-CHERRIES guidelines and recruited adult survivors (injury>1 y prior) via their available...
In the oil dispersion of chitosan, formation a capillary bridge was triggered by adding small amount water to obtain an oleogel. With this method, types liquid and ratio oil/chitosan/water were explored achieve optimal MCT performed best, followed soybean oil, which chosen for its edibility cost. Increasing chitosan from 15% 45% reduced loss 46% 13%, raising water/chitosan 0 0.8 lowered 37% 13%. After normalization, 1:0.45:0.36, yielding solid-like appearance, minimal maximum gel strength...