A5101506901- Cardiovascular Function and Risk Factors
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cytomegalovirus and herpesvirus research
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Neurological Disease Mechanisms and Treatments
- Cardiac Valve Diseases and Treatments
- Chronic Myeloid Leukemia Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Traditional Chinese Medicine Studies
- Pulmonary Hypertension Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Viral-associated cancers and disorders
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
Hebei Medical University
2019-2025
Guangdong Provincial People's Hospital
2019-2025
Hubei University of Medicine
2025
Southern Medical University
2003-2025
Central South University
2006-2025
Guizhou Provincial People's Hospital
2024-2025
Third Xiangya Hospital
2025
Guangdong Academy of Medical Sciences
2019-2025
Third Hospital of Hebei Medical University
2025
Human Longevity (United States)
2024
The aim of this study was to investigate the efficacy exenatide and insulin glargine in patients with newly diagnosed type 2 diabetes mellitus (T2DM) nonalcoholic fatty liver disease (NAFLD).We performed a 24-week randomized controlled multicentre clinical trial. Seventy-six were randomly assigned 1:1 receive or treatment. endpoints included changes fat content (LFC), visceral adipose tissue (VAT), subcutaneous (SAT) measured by magnetic resonance spectroscopy, blood glucose, enzymes, lipid...
Abstract Background A cluster of acute respiratory illness, now known as Corona Virus Disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases are more likely be to infected SARS-CoV-2 and result in severe outcomes elevated case-fatality rate. Meanwhile, have high prevalence the middle-aged elderly population. However, despite several researches COVID-19, implications related it still remains largely unclear....
Rats with streptozotocin (STZ)-induced diabetes were studied in order to identify abnormal microRNA (miRNA) expression profiles diabetic retinopathy (DR) and ascertain miRNAs associated DR. Histopathologically, we observed characteristic features of DR rats at 10 weeks after STZ injection. Investigation miRNA the retinas control using microarrays revealed that many abnormally expressed On basis their fold changes probability values, a total 37 selected for further validation by real-time PCR...
Type 2 diabetes (T2D) is characterized by progressive and inexorable β-cell dysfunction, leading to insulin deficiency. Novel strategies preserve the remaining β-cells restore function for treatment of are urgently required. Mesenchymal stem cells (MSCs) have been exploited in a variety clinical trials aimed at reducing burden immune-mediated disease. The aim present trial was assess safety efficacy umbilical cord-derived MSC (UCMSC) transplantation patients with T2D. UCMSC application were...
Magnesium (Mg), a nutritional element which is essential for bone development and mineralization, has role in the progression of osteoporosis. Osteoporosis multifactorial disease characterized by significant deterioration microstructure loss. Mg deficiency can affect structure an indirect way through two main regulators calcium homeostasis (parathyroid hormone vitamin D). In human osteoblasts (OBs), parathyroid regulates expression receptor activator nuclear factor-κ B ligand (RANKL)...
Metastatic prostate cancer is a terminal disease, and the development of reliable prognostic tools more effective therapy critically important for improved disease survival management. This study was aimed at identifying genes that are differentially expressed in metastatic nonmetastatic cells and, as such, could be critical metastasis. Long-SAGE analysis used to compare transplantable human subline, PCa1-met, with counterpart, PCa2. Both sublines were developed from patient's specimen via...
Background Accumulating evidence shows that the novel anti-inflammatory cytokine IL-35 can efficiently suppress effector T cell activity and alter progression of inflammatory autoimmune diseases. The two subunits IL-35, EBI3 p35, are strongly expressed in human advanced plaque, suggesting a potential role atherosclerosis coronary artery disease (CAD). However, plasma levels patients with CAD have yet to be investigated. Methods Plasma IL-10, TGF-β1, IL-12 IL-27 were measured using an ELISA...
Improvement of current GVHD prophylactic therapies remains an important goal in the allo-HSCT. We have described a novel prophylaxis regimen single institution trial. The Chinese Bone Marrow Transplant Cooperative Group (CBMTCG) initiated phase II multicenter study. study was designed as prospective, arm open-label, clinical primary endpoint improvement aGVHD by 25% over historical control (40%) patients. 508 patients were enrolled. All received cyclosporine A (CsA), methotrexate (MTX) and...
Abstract Renal fibrosis is the hallmark of chronic kidney diseases (CKD) and its development progression are significantly affected by epigenetic modifications. Rhein, a plant-derived anthraquinone, displays strong anti-fibrosis properties, but protective mode action remains incompletely understood. Here we explore mechanism Rhein anti-renal investigating regulation Klotho, known renal anti-fibrotic protein whose suppression after injury reportedly involves aberrant DNA methylation. We...
Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate (EMS)-induced soybean (Glycine max) population, consisting of 21,600 independent M2 lines, was developed. Over 1,000 M4 (5) families, with diverse abnormal phenotypes seed composition, shape, plant morphology maturity that are stably expressed across different environments generations were identified. Phenotypic analysis the...
<p dir="ltr"><a href="" target="_blank"><b>OBJECTIVE</b></a></p><p dir="ltr">Individuals with type 2 diabetes (T2D) frequently exhibit impaired lung function, potentially accelerating the onset of cardiovascular diseases (CVD), although prospective studies remain limited. We aimed to explore relationship between function impairment and risk CVD mortality within this high-risk population.</p><p dir="ltr"><b>RESEARCH DESIGN AND...
OBJECTIVE Individuals with type 2 diabetes (T2D) frequently exhibit impaired lung function, potentially accelerating the onset of cardiovascular disease (CVD), although prospective studies remain limited. We aimed to explore relationship between function impairment and risk CVD mortality within this high-risk population. RESEARCH DESIGN AND METHODS This study included 16,242 participants T2D free from UK Biobank. Obstructive physiology (OP), restrictive (RP), preserved ratio spirometry...
Background Modic changes are caused by various factors, such as degenerative processes, inflammation, biomechanical, genetic, and metabolic infection, smoking. Bacteria have been identified in human intervertebral discs 16S rRNA sequencing; however, the low microbial biomass disc tissue limits species-level analyses using this approach. In study, we employed 2bRAD-M (2b Restriction Site Associated DNA sequencing for Microbiome), a new technology capable of accurately characterizing bacteria,...