A5077458512- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Bone and Joint Diseases
- RNA Research and Splicing
- Cytomegalovirus and herpesvirus research
- Cancer-related Molecular Pathways
- Renal Transplantation Outcomes and Treatments
- Angiogenesis and VEGF in Cancer
- Lymphoma Diagnosis and Treatment
- Acute Kidney Injury Research
- Diabetes and associated disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Nanowire Synthesis and Applications
- Retinoids in leukemia and cellular processes
The University of Texas MD Anderson Cancer Center
2016-2024
First Affiliated Hospital of GuangXi Medical University
2010-2023
Guangxi Medical University
2011-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2008
Institute of Hematology & Blood Diseases Hospital
2006
Molecular analysis is a promising source of clinically useful prognostic biomarkers. The aim this investigation was to identify biomarkers for patients with acute myeloid leukemia (AML) by using the gene expression profile dataset from public database.The and corresponding overall survival (OS) information three cohorts AML GSE12417 Cancer Genome Atlas project (TCGA-LAML) were included in present study. Prognostic screening performed package, whereas time-dependent receiver operating...
Improvement of current GVHD prophylactic therapies remains an important goal in the allo-HSCT. We have described a novel prophylaxis regimen single institution trial. The Chinese Bone Marrow Transplant Cooperative Group (CBMTCG) initiated phase II multicenter study. study was designed as prospective, arm open-label, clinical primary endpoint improvement aGVHD by 25% over historical control (40%) patients. 508 patients were enrolled. All received cyclosporine A (CsA), methotrexate (MTX) and...
Minimal residual disease (MRD) is an important prognostic factor for survival in adults with acute leukemia. The role of pretransplantation MRD status myelodysplastic syndrome excess blasts (MDS-EB) unknown. This study retrospectively analyzed the relationship between and long-term survival.Patients MDS-EB who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from March 5, 2005, to November 8, 2020, were included. was using univariate multivariate logistic regression...
The regulatory mechanism of hypoxia-inducible factor-1α (HIF-1α) is complex. HIF-1α may inhibit or promote apoptosis in osteoblasts under different physiological conditions, and induce bone regeneration repair injury coordination with angiogenesis. relationship between H2O2 HIFs complex, this study aimed to explore the role H2O2-induced apoptosis. Dimethyloxallyl glycine (DMOG) 2-Methoxyestradiol (2ME) were used stabilize HIFs, respectively. Cell viability was assessed CCK8. Apoptosis ROS...
Background: Tumor protein p53 ( TP53 ) mutations are not only a risk factor in acute myeloid leukemia (AML) but also potential biomarker for individualized treatment options. This study aimed to investigate pathways and genes associated with adult de novo AML. Methods: An RNA sequencing dataset of AML was downloaded from The Cancer Genome Atlas database. Differentially expressed (DEGs) were identified by edgeR the R platform. Key using following bioinformatics tools: gene set enrichment...
What is known and objectives Augmented renal clearance (ARC) characterized by enhanced clearance, which leads to insufficient vancomycin exposure treatment failure. In haematologic malignancy patients, determination of optimal dosage essential because high stake life-threatening bacterial infection increased clearance. The aim this study was describe pharmacokinetic parameters in with augmented children define the appropriate dosing regimen achieve an AUC0-24h/MIC ≥400. Methods Hematologic...
// Gang Yao 1, 2, * , Qi Zhang Thorsten R. Doeppner 3 Feng Niu 1 Qiaochuan Li 4 Yanping Yang Ulrike Kuckelkorn 5 Nina Hagemann Wei Dirk M. Hermann Yun Dai 6 Wen Zhou 7 Fengyan Jin Cancer Center, the First Affiliated Hospital, Jilin University, Changchun, Jilin, China 2 Department of Neurology, Second University Hospital Essen, Germany Hematology, Guangxi Medical Nanning, Guangxi, Biochemistry, Charité Universitätsmedizin Berlin, Medicine, Virginia Commonwealth Massey Richmond,...
Abstract Hepatic veno-occlusive disease or sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the present prospective study, we aimed to investigate incidence, management, and outcome VOD/SOS in patients with thalassemia major (TM) who received allo-HSCT. was diagnosed classified based on modified Seattle criteria. The prophylactic regimen for combination treatment dalteparin...
This study mainly used The Cancer Genome Atlas (TCGA) RNA sequencing dataset to screen prognostic snoRNAs of acute myeloid leukemia (AML), and for the construction signature AML. A total 130 AML patients with were screenning. SnoRNAs co-expressed genes differentially expressed (DEGs) functional annotation, as well gene set enrichment analysis (GSEA). Connectivity Map (CMap) also potential targeted drugs screening. Through genome-wide screening, we identified 30 that significantly associated...
In the bone marrow (BM), hematopoietic stem and progenitor cells (HSPCs) reside in specialized niches near osteoblast at endosteum. HSPCs that egress to peripheral blood are widely used for transplant, mobilization is most commonly performed with recombinant human granulocyte colony-stimulating factor (G-CSF). However, cellular targets of G-CSF initiate cascade remodeling not completely understood. Here, we examined whether T B lymphocytes modulate niche influence HSPC mobilization. We...
As an inherited anemia, thalassemia major (TM) is currently only curable with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here we report allo-HSCT protocol for patients TM who received a combination of granulocyte colony-stimulating factor-primed bone marrow and peripheral blood cells (G-BM & PBSCs) from matched sibling donor (MSD). The conditioning regimen consisted i.v. busulfan, cyclophosphamide, fludarabine, antithymocyte globulin. Chimerism analysis was performed all...
The clinical outcome of hematopoietic stem cell transplantation (HSCT) in those with severe beta-thalassemia (β-TM) is closely related to post-transplantation immune reconstitution (IR). However, the data on IR these settings are scarce.A prospective analysis and 47 children β-TM who underwent vivo T-cell depletion myeloablative conditioning matched sibling donor HSCT was performed. Immune reconstitution, including subset counts, as well generation new T B cells assays after HSCT,...
Background: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for hematological disorders. Tacrolimus widely used after HSCT, but it has highly interindividual variable pharmacokinetics. Population pharmacokinetics (PPK) researches of tacrolimus in children with β-thalassemia major (β-TM) undergoing HSCT are insufficient. Objective: To establish a PPK model β-TM and optimize initial dosing regimen achieving target concentration 5 to 15 ng/mL. Methods: Data on patients...
None declared. The peer review history for this article is available at https://publons.com/publon/10.1111/odi.13658.
Purpose: To determine the prevalence and underlying pathology of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia (NTDT). Patients methods: In this study, we enrolled 211 aged 4-63 years NTDT, including 79 β intermedia patients, 114 Hb H disease 18 E/β patients. All had oral tolerance test, serum ferritin (SF), model assessment (HOMA) liver iron concentration (LIC) measurement. One hundred twenty healthy age-matched controls were also used for...
Objective: The present study aimed to determine the prognostic value of HOXA cluster antisense RNA2 (HOXA-AS2) in acute myeloid leukemia (AML), and explore its potential molecular mechanisms.We also screening drugs targeting HOXA-AS2 AML.Methods: level 3 raw genome-wide RNA sequencing dataset AML was download from Cancer Genome Atlas (TCGA) Data Portal, mechanisms prediction were explored using multiple bioinformatics analysis approaches.Results: TCGA cohort indicated that significantly...
The aim of the present study was to identify potential molecular mechanisms and therapeutic targets in regards isocitrate dehydrogenase 2 (IDH2) R140Q-mutated acute myeloid leukemia (AML). An RNA sequencing dataset IDH2 wild-type adult de novo AML bone marrow samples obtained from Cancer Genome Atlas (TCGA) database. edgeR package used screen for differentially expressed genes (DEGs), were identified using Database Annotation, Visualization, Integrated Discovery (DAVID) v6.8, Biological...
Abstract The purpose was to predict the risk of acute kidney injury (AKI) within 100 days after hematopoietic stem cell transplantation (HSCT) in patients with hematologic disease by using a new predictive nomogram. Collect clinical data undergoing HSCT our hospital from August 2012 March 2018. Parameters non-zero coefficients were selected Least Absolute Selection Operator (LASSO). Then these parameters build nomogram model. Receiver operating characteristic (ROC) curve, calibration...
Abstract Hu8F4 is a T cell receptor (TCR)-like antibody with high affinity for leukemia-associated antigen PR1/HLA-A2 epitope. Adapted into chimeric (CAR) format, Hu8F4-CAR comprised of the scFv, human IgG1 CH2CH3 extracellular spacer domain, CD28 costimulatory and CD3ζ signaling domain. We have demonstrated efficacy Hu8F4-CAR-T cells against PR1/HLA-A2-expressing lines leukemic blasts from AML patients in vitro. Previous studies shown that modification Fc domains IgG4 regions can eliminate...
Objective To investigate the effects of different treatment protocols on non-Hodgkin's lymphoma (NHL) with bone marrow involvement (BMI).Methods The clinical data 148 patients NHL BMI,108 undergoing CHOP regimen,51 dose-intensive regimens,13 regimen+rituximab,and 27 hemopoietic stem cell transplantation (HSCT) after protocol remission.The curative were retrospectively analyzed.Results (1)The response rate (RR) for whole group was 80.4%,with a complete remission (CR) 60.7%.The treated...
To investigate the changes and mechanism of angiopoietin1 (Ang1) in murine bone marrow during G-CSF induced mobilization hematopoietic stem/progenitor cell.The proportion Lin-Sca1⁺cKit⁺ (LSK) cells peripheral blood C57BL/6 mice before after was detected by flow cytometry. Expression Ang1 osteocalcin (OCN) HSC were determined immunohistochemistry, enzyme linked immunosorbent assay (ELISA) real-time fluorescence quantitative PCR. The number osteoblasts counted under microscope.After treated...