A5100725998- Antibiotics Pharmacokinetics and Efficacy
- Intensive Care Unit Cognitive Disorders
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Biosimilars and Bioanalytical Methods
- Acute Lymphoblastic Leukemia research
- Metabolomics and Mass Spectrometry Studies
- Hemoglobinopathies and Related Disorders
- Neutropenia and Cancer Infections
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
- Anesthesia and Sedative Agents
- EEG and Brain-Computer Interfaces
- Acute Kidney Injury Research
- Fungal Infections and Studies
First Affiliated Hospital of GuangXi Medical University
2014-2025
Guangxi Medical University
2014-2025
Peking University Third Hospital
2017-2025
Peking University
2017-2025
Shanghai Sixth People's Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Ningxia Medical University
2024
Fudan University
2009-2023
Zhongshan Hospital
2010-2023
Zunyi Medical University
2023
Systemic inflammation often induces neuroinflammation and disrupts neural functions, ultimately causing cognitive impairment. Furthermore, neuronal is the key cause of many neurological conditions. It particularly important to develop effective neuroprotectants prevent control inflammatory brain diseases. Baicalin (BAI) has a wide variety potent neuroprotective enhancement properties in various models injury through antioxidation, anti-inflammation, anti-apoptosis, stimulating neurogenesis....
Postoperative delirium (POD) is a common postsurgical complication that seriously affects patients' prognosis and imposes heavy burden on families society. Type 2 diabetes mellitus (T2DM) major risk factor for POD. The susceptibility mechanisms of POD in T2DM individuals the role exercise preconditioning remain unclear. Adult rats with without were used to assess promotive effect postoperative delirium-like behavior. diabetic also subjected swimming program before surgery. potential...
Objective: Traditional Chinese medicine (TCM) has been used as a complementary treatment for cancer patients, but there no quantitative comprehensive analysis of TCM's efficacy. The purpose this paper is to explore the current status and hotspots TCM in research from 2002 2022 provide reference future research. Methods: We retrieved articles published between Web Science database analyzed them using R software, VOSviewer, CiteSpace software. Results: A total 7,129 were included study....
The 3D culture of intestinal organoids entails embedding isolated crypts and bone marrow mesenchymal stem cells within a growth factor-enriched matrix gel. This process leads to the formation hollow microspheres with structures resembling epithelial cells, which are referred as organoids. These encompass various functional cell types found in small intestine closely mimic organizational patterns intestine, earning them name “mini-intestines”. Intestinal tumors prevalent digestive system...
Objective The aim of this study is to establish a population pharmacokinetic (PK) model for patients undergoing continuous veno-venous hemodiafiltration (CVVHDF) and optimize the dosing regimen colistin sulfate. Methods A prospective observational in single center was conducted on who were administrated with sulfate CVVHDF at least 48 h. Blood samples obtained prior four six blood (primarily C 0.5h , 1h 2h 4h 6h ) after dosing. concentration determined by ultra-high performance liquid...
Artesunate (ART) is the derivative of artemisinin isolated from traditional Chinese medicine qinghao. Although several studies reported efficiency artesunate in treatment malaria, inhibiting fibroblasts and collagen synthesis, association between scar formation unclear. The research was designed to study significance on expression transforming growth factor (TGF-β1) small mother against decapentaplegic (SMAD3) rabbit's ear hypertrophic model. Twenty-four New Zealand white rabbits were...
Background: It is reported that various diseases such as non-alcoholic fatty liver disease (NAFLD) are associated with imbalance of microbiome. And FXR has been well investigated in diseases. Purpose: The objective this study was to identify the role farnesoid X receptor agonist obeticholic acid via targeting gut microbiota NAFLD. Patients and methods: Male C57BL/6 mice were fed either a normal-chow diet or high-fat (HFD). Obeticholic acid(30mg/(kg·d)) and/or combination antibiotics...
Stress-induced α-synuclein aggregation, especially the most toxic species (oligomers), may precede synaptic and cognitive dysfunction.Under pathological conditions, is degraded primarily through autophagic/lysosomal pathway.We assessed involvement of autophagy in aggregation impairment following general anesthesia surgical stress.Autophagy was found to be suppressed aged rat hippocampus after either 4-h propofol alone or 2-h during a laparotomy surgery.This inhibition accompanied by profound...
Pancreatic cancer is a common malignant tumor with high incidence and mortality rate. The prognosis of patients pancreatic considerably poor due to the lack effective treatment in clinically. Despite numerous studies have revealed that baicalein, natural product, responsible for suppressing multiple cells proliferation, motility invasion. mechanism by which baicalein restraining progression remains unclear. In this study, we firstly verified plays critical role inhibiting tumorigenesis vitro...
Background Presenteeism is defined as the behavior of people who insist on attending work despite complaints ill health that should prompt rest and absence from work. Due to heavy workloads irreplaceable duties nursing service, nurses are a typical representative group suffering presenteeism. Although more scholars have recently begun focusing presenteeism, an abundant number studies tended focus presenteeism's external objective factors. There is, thus, lack based variables related...
The diagnostic and economic value of carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9) CA72-4 for gastrointestinal malignant tumors lacked evaluation in a larger scale.To reassess the three tumor biomarkers.A retrospective analysis all 32857 subjects who underwent CEA, CA19-9, CA72-4, gastroscopy colonoscopy from October 2006 to May 2018 was conducted. Then, we assessed discrimination clinical usefulness. Total cost, cost per capita cost-effectiveness ratios were used evaluate two...
Paroxysmal kinesigenic dyskinesia (PKD) is associated with a disturbance of neural circuit and network activities, while its neurophysiological characteristics have not been fully elucidated. This study utilized the high-density electroencephalogram (hd-EEG) signals to detect abnormal brain activity PKD provide biomarker for clinical diagnosis progression monitoring. The resting hd-EEGs are recorded from two independent datasets then source-localized measuring oscillatory activities function...
Delayed neurocognitive recovery (dNCR) is a common postoperative complication in geriatric surgical patients for which there no efficacious therapy. Cholecystokinin octapeptide (CCK-8), an immunomodulatory peptide, regulates memory and learning. Here, we explored the effects mechanism of action CCK-8 on dNCR.We applied laparotomy to establish model dNCR aged mice. Morris water maze fear conditioning tests were used evaluate cognition. Immunofluorescence was detect density CCK-8, A1 reactive...
To build a population pharmacokinetic model for Chinese adult patients and develop initial dosage regimens with different degrees of renal function to achieve target steady-state trough concentrations in the range 10 - 15 20 mg/l.Data on serum vancomycin concentration was collected from retrospective study including 72 patients. NONMEM used model, one-compartment chosen describe concentration-time profile. Internal evaluation by bootstrap visual predictive check (VPC) performed evaluate...
Transplantation of Schwann cells (SCs) can promote axonal regeneration and formation the myelin sheath, reduce inflammation, repair to damaged nerve. Our previous studies have shown that transplantation free or micro-encapsulated olfactory ensheathing relieve neuropathic pain. There are no related reports regarding whether SCs alleviate pain mediated by P2X2/3 receptors. In present study, we in alginic acid transplanted them into region surrounding injured sciatic nerve rat model chronic...
An amendment to this paper has been published and can be accessed via the original article.