A5103060243- Ovarian function and disorders
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Gut microbiota and health
- Reproductive Health and Technologies
- Immune cells in cancer
- RNA modifications and cancer
- Endometrial and Cervical Cancer Treatments
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Inflammasome and immune disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Acupuncture Treatment Research Studies
- Ginseng Biological Effects and Applications
- Nausea and vomiting management
- Drug Transport and Resistance Mechanisms
- Electromagnetic Fields and Biological Effects
Zhongshan Hospital
2010-2024
Shanghai Institute of Hematology
2022-2024
Fudan University
2010-2024
Shanghai Changzheng Hospital
2023-2024
Chongqing Medical University
2021-2024
Shaanxi Normal University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2024
Second Military Medical University
2014-2023
Changhai Hospital
2014-2023
First Hospital of Jiaxing
2023
Abstract Gastric cancer remains a leading cause of cancer-related death worldwide, largely due to inadequate screening methods, late diagnosis, and limited treatment options. Liquid biopsy has emerged as promising non-invasive approach for prognosis by detecting circulating tumor components like DNA (ctDNA) in the blood. Numerous gastric cancer-specific ctDNA biomarkers have now been identified. CtDNA analysis provides insight into genetic epigenetic alterations tumors, holding promise...
The hepatotoxicity of two types multi-walled carbon nanotubes (MWCNTs), acid-oxidized MWCNTs (O-MWCNTs) and Tween-80-dispersed (T-MWCNTs), were investigated with Kunming mice exposed to 10 60 mg kg(-1) by intravenous injection for 15 d. Compared the PBS group, body-weight gain decreased level total bilirubin aspartate aminotransferase increased in MWCNT-exposed group a significant dose-effect relationship, while tumor necrosis factor alpha did not show statistical change within Spotty...
Background. Allicin, the major component of freshly crushed garlic, is one most biologically active compounds garlic; it has been reported to induce apoptosis in cancer cells; however, mechanism by which allicin exerts its apoptotic effects not fully understood. The aim present study was further elucidate pathways induced human ovarian cell line SKOV3. Methods. Cell proliferation and were measured cell-counting assay flow cytometry analysis. Activation signaling pathway screened...
Androgen excess could profoundly lead to follicular dysplasia or atresia, and finally result in polycystic ovary syndrome (PCOS); however, the exact mechanism remains be fully elucidated.PCOS model rats were induced by dehydroepiandrosterone, their fertility was assessed. The ovarian granulosa cells (GCs) from matured follicles of PCOS collected identified immunofluorescence. mitochondrial ultrastructure observed transmission electron microscope function determined detecting adenosine...
The toxicity of polyethylene-glycol functionalized (PEGylated) multi-walled carbon nanotubes (MWCNTs) and non-PEGylated MWCNTs in vivo was evaluated compared. Mice were exposed to by intravenous injection. activity level glutathione, superoxide dismutase gene expression liver, as well some biochemical parameters the tumor necrosis factor alpha blood measured over 2 months. pathological electron micrographic observations liver evidently indicate that damage caused is slightly more severe than...
Background: It is reported that various diseases such as non-alcoholic fatty liver disease (NAFLD) are associated with imbalance of microbiome. And FXR has been well investigated in diseases. Purpose: The objective this study was to identify the role farnesoid X receptor agonist obeticholic acid via targeting gut microbiota NAFLD. Patients and methods: Male C57BL/6 mice were fed either a normal-chow diet or high-fat (HFD). Obeticholic acid(30mg/(kg·d)) and/or combination antibiotics...
Background Polycystic ovary syndrome (PCOS) is a kind of endocrine and metabolic disorder, disturbing the females reproductive age. Here, we aimed to investigate characteristics overweight women with PCOS analyze possible mechanisms. Methods We conducted cross-sectional study on 947 patients PCOS, who were classified according body mass index (BMI) as (BMI ≥ 24 kg/m 2 ) or non-overweight ≤ 23.9 ). The clinical symptoms, features, status, inflammatory levels comprehensively assessed compared...
Abstract Background Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease that has great impact on women’s physical and mental health. It burden to social patients’ economy. In recent years, researchers’ understanding of PCOS reached new level. However, many reports have different directions, overlapping phenomena exist. Therefore, clarifying the research status important. This study aims summarise predict hot spots in future by Bibliometricx. Results The keywords...
Objective . To explore the effect of Cryptotanshinone on reversing reproductive and metabolic disturbances in polycystic ovary syndrome (PCOS) model rats possible regulatory mechanisms. Methods PCOS were induced by subcutaneous injection dehydroepiandrosterone (DHEA) verified histological screening vaginal exfoliated cells. After intervention, rats’ body weight morphological observed; serum biochemical assessments analyzed radioimmunoassay (RIA) key genes proteins related with anabolism...
The mechanism of Nova1's role in hepatocellular carcinoma has not been delineated. Also its interaction with GABAA receptor γ2 HCC is unveiled. This study aimed to make it clear the distribution, prognostic value GABAARγ2 human carcinoma. And tumorigenesis under regulation alternative splicing factor Nova1. Immunohistochemistry staining was used investigate distribution and clinical significance protein expression In vivo tumorigenticity test conducted nude mice by Later, western blot...
Ovarian cancer (OC) is a highly malignant gynecologic tumor with few treatments available and poor prognosis the currently diagnostic markers interventions. More effective methods for diagnosis treatment are urgently needed. Although current evidence implicates ferroptosis in development therapeutic responses of various types tumors, it unclear to what extent affects OC. To explore potential ferroptosis-related genes as biomarkers molecular targets OC intervention, this study collected...
Background: Tumor-associated neutrophils (TANs) contribute to tumor progression, invasion, and angiogenesis. However, most studies focus on infiltration while the roles of circulating in progression remain unclear. This study was aimed verify pro-tumor effects its' mechanism HCC. Methods: We collected clinical data 127 HCC patients underwent TACE. The prognostic factors for overall survival (OS) were analyzed by Kaplan-Meier curve Cox models. Circulating sorted co-cultured with human cell...
Gut microbiota disorders are closely related to polycystic ovarian syndrome (PCOS). Buzhong Yiqi prescription (BZYQ) has a significant clinical effect on the treatment of patients with obesity exhibiting PCOS and phlegm-dampness caused by spleen deficiency (SPSD). Hence, this study aimed explore gut fecal metabolite alterations in such treated BZYQ. Fifty eligible manifesting SPSD participated agreed undergo 3 months BZYQ treatment. Results showed that significantly alleviated serum...
Abstract Metabolic reprogramming is a hallmark of neutrophil activation in sepsis. LncRNAs play important roles manipulating cell metabolism; however, their specific involvement sepsis remains unclear. Here we found that 11 lncRNAs and 105 mRNAs were differentially expressed three transcriptome datasets (GSE13904, GSE28750, GSE64457) gene expression blood leukocytes neutrophils septic patients healthy volunteers. After Gene Ontology biological process analysis lncRNA–mRNA pathway network...
Dysregulation of the aldehyde dehydrogenase (ALDH) family has been implicated in various pathological conditions, including cancer.However, a systematic evaluation ALDH alterations and their therapeutic relevance hepatocellular carcinoma (HCC) remains lacking.Herein, we found that 15 19 ALDHs were transcriptionally dysregulated HCC tissues compared to normal liver tissues.A four gene signature, ALDH2, ALDH5A1, ALDH6A1, ALDH8A1, robustly predicted prognosis defined high-risk subgroup...
Objective. To explore the effects of puerarin to treat endometriosis (EMT) model rats and possible regulatory mechanisms. Methods. EMT were surgically induced by autotransplantion endometrial tissues. The appropriate dosage was determined observing pathologic morphology ectopic tissues detecting levels estradiol (E2) prostaglandin E2 (PGE2) both serum related genes proteins analyzed Real-time PCR immunohistochemistry (IHC) Results. Puerarin could reduce PGE2 prevent growth endometrium...
Abstract Background Though c ircular RNAs (circRNAs) are the key regulators in tumor carcinogenesis, they remain largely unexplored hepatocellular carcinoma (HCC). Methods The expression of RanGAP1-derived circRNAs (circ_0063531, circ_0063534, circ_0063513, circ_0063518, circ_0063507, circ_0063723) were evaluated eight paired HCC and normal tissues, correlation between circRanGAP1 (circ_0063531) clinicopathological characteristics 40 patients was determined. association miR-27b-3p or NRAS...
High androgen levels in patients suffering from polycystic ovary syndrome (PCOS) can be effectively reversed if the herb Scutellaria baicalensis is included traditional Chinese medicine prescriptions. To characterize effects of baicalin, extracted S. baicalensis, on biosynthesis NCI-H295R cells and hyperandrogenism PCOS model rats to elucidate underlying mechanisms. The optimum concentration intervention time for baicalin treatment were determined by...