A5002397146- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Phagocytosis and Immune Regulation
- Antibiotic Resistance in Bacteria
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Cleft Lip and Palate Research
- Bacterial Infections and Vaccines
- Traditional Chinese Medicine Studies
- Bacterial biofilms and quorum sensing
- Nosocomial Infections in ICU
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Trace Elements in Health
- Tryptophan and brain disorders
- Nanoplatforms for cancer theranostics
- Streptococcal Infections and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Organ Transplantation Techniques and Outcomes
- Adenosine and Purinergic Signaling
Second Affiliated Hospital of Xi'an Jiaotong University
2025
Shanghai Institute of Hematology
2022-2024
Zhongshan Hospital
2021-2024
Fudan University
2006-2024
Sun Yat-sen University
2022-2024
Dalian Medical University
2024
Qingdao University
2023-2024
Affiliated Hospital of Qingdao University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Huashan Hospital
2001-2020
Although quinolone resistance usually results from chromosomal mutations, recent studies indicate that can also be plasmid mediated. The gene responsible, qnr, is distinct the known genes and in previous seemed to restricted Klebsiella pneumoniae Escherichia coli isolates University of Alabama Birmingham, where this was discovered. In Shanghai, frequency ciprofloxacin E. has exceeded 50% since 1993. Seventy-eight unique ciprofloxacin-resistant clinical Shanghai hospitals were screened for...
Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells HCC, suggesting that a better understanding of intrinsic processes by which tumor regulate macrophages could help identify strategies to improve response immunotherapy. As signaling lymphocytic activation molecule (SLAM) family members various functions, we investigated role specific SLAM receptors immunobiology HCC. Comparison transcriptomic landscapes...
Abstract The CXCL12/CXCR4 axis has been posited widely to have significant roles in many primary tumors and metastases. It is known that CXCR7 can also be engaged by CXCL12, but the exact function of controversial. This prompted us investigate expression, specific signal transduction hepatocellular carcinoma (HCC). In this study, CXCR4 were differentially expressed nine cell lines HCC, elevated expression both CXCL4 correlated with highly metastatic ability HCC cells. Moreover, was...
This study aimed to investigate the beneficial effects of myricetin in a diet-induced nonalcoholic steatohepatitis (NASH) model and underlying mechanism. C57BL/6J mice were fed standard chow or choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) for 8 weeks with treatment (100 mg/kg) vehicle by daily gavage. Hepatic inflammation, steatosis, fibrosis, hepatic stellate cells (HSC) activation assessed. We also analyzed M1 M2 macrophages its related markers livers from NASH RAW264.7...
Dysregulation of the aldehyde dehydrogenase (ALDH) family has been implicated in various pathological conditions, including cancer.However, a systematic evaluation ALDH alterations and their therapeutic relevance hepatocellular carcinoma (HCC) remains lacking.Herein, we found that 15 19 ALDHs were transcriptionally dysregulated HCC tissues compared to normal liver tissues.A four gene signature, ALDH2, ALDH5A1, ALDH6A1, ALDH8A1, robustly predicted prognosis defined high-risk subgroup...
Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive whether can drive the functional polarization of context cancer and how tumor affect iron-handing properties TAM. In this study, using hepatocellular carcinoma (HCC) as study model, we aimed explore effect mechanism reduced ferrous iron
Although sorafenib, a multi-kinase inhibitor, has provided noteworthy benefits in patients with hepatocellular carcinoma (HCC), the inevitable side effects, narrow therapeutic window, and low bioavailability seriously affect its clinical application. To be clinically distinctive, innovative drugs must meet needs of reaching tumor tissues cause limited effects to normal organs tissues. Recently, photodynamic therapy, utilizing combination photosensitizer light irradiation, was selectively...
Ferroptosis is identified as a novel type of cell death with distinct properties involved in physical conditions and various diseases, including cancers. It considered that ferroptosis provides promising therapeutic strategy for optimizing oncotherapy. Although erastin an effective trigger, the potential its clinical application largely restricted by poor water solubility concomitant limitations. To address this issue, innovative nanoplatform (PE@PTGA) integrated protoporphyrin IX (PpIX)...
The virus-encoded Tat protein strongly activates transcription of human immunodeficiency virus (HIV). A well-recognized mechanism involves interaction with the nascent RNA transcript viral tar gene; mutation greatly decreases activation by Tat. However, still provides a low level activation, demonstrating that it also has tar-independent mode action. We propose this action is through gene to produce tumor necrosis factor alpha. This cytokine and other compounds activate NF-kappa B...
<div>Abstract<p>Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells HCC, suggesting that a better understanding of intrinsic processes by which tumor regulate macrophages could help identify strategies to improve response immunotherapy. As signaling lymphocytic activation molecule (SLAM) family members various functions, we investigated role specific SLAM receptors immunobiology HCC. Comparison...
ABSTRACT Objective Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, various physiological functions. In this study, we aimed to define spectrum COMs analysis its features or possible influencing factors improve surveillance control disease. Materials Methods We organized a multicenter survey from 19 hospitals in 14 provinces. The clinical data COM cases were collected...
Sorafenib resistance is often developed and impedes the benefits of clinical therapy in hepatocellular carcinoma (HCC) patients. However, relationship between sorafenib tumor immune environment adjuvant drugs for sorafenib-resistant HCC are not systemically identified. This study first analyzed expression profiles cells to explore cell infiltration levels differentially expressed immune-related genes (DEIRGs). The prognostic value DEIRGs was using Cox regression Kaplan-Meier analysis based...