A5101824404- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Cleft Lip and Palate Research
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Craniofacial Disorders and Treatments
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Tumors and Oncological Cases
- Cancer, Hypoxia, and Metabolism
- Environmental Education and Sustainability
- Consumer Behavior in Brand Consumption and Identification
- Digital Media and Visual Art
- Microbial Metabolic Engineering and Bioproduction
- Microbial Fuel Cells and Bioremediation
- Cancer-related gene regulation
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
Inner Mongolia People's Hospital
2024
Xuzhou Medical College
2024
Shanghai University of Traditional Chinese Medicine
2022-2023
Suzhou Institute of Systems Medicine
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
Athlone Institute of Technology
2021
People’s Hospital of Rizhao
2021
La Trobe University
2018-2019
Northeast Normal University
2016
Chinese PLA General Hospital
2015
MiR-125a has been characterized as a tumor suppressor in several cancers. However, the role of miR-125a cervical cancer is unknown. In this study, we found expression was downregulated patients, and negatively correlated with size, FIGO stage, preoperative metastasis. Kaplan-Meier analysis showed that predicted favorable outcome for patients. Dual luciferase assays identified STAT3 gene novel direct target miR-125a. Functional studies overexpression significantly suppressed growth, invasion...
Ferroptosis is a kind of cell death triggered by intracellular phospholipid peroxidation. Human umbilical vein blood endothelial progenitor cells-Exosomes (EPCs-Exos) affect ferroptosis. This study sought to explore the mechanism EPCs-Exos in human (HUVEC) were isolated and identified. HUVECs treated with Erastin at IC50 concentration. Ferroptosis-related indexes iron ion content detected using kits. HUVEC migration angiogenesis before/after ferroptosis inhibitor treatment observed scratch...
Background: Gynecological malignancies, such as endometrial cancer (EC) and uterine are prevalent. Increased Acyl-CoA synthetase long-chain family member 1 (ACSL1) activity may contribute to aberrant lipid metabolism, which is a potential factor that contributes the pathogenesis of cancer. This study aimed elucidate molecular mechanisms by ACSL1 involved in metabolism cancer, providing valuable insights for targeted therapeutic strategies. Methods: Xenograft mouse models were used assess...
To illustrate the biological function of long non-coding RNA (lncRNA) SNHG3 in deterioration colorectal cancer (CRC) by regulating miR-370-5p/EZH1 axis.SNHG3 levels fifty pairs CRC and non-tumor tissues were examined quantitative real-time polymerase chain reaction (qRT-PCR). Its correlation to tumor staging, lymph node metastasis prognosis was analyzed. Cell counting kit-8 (CCK-8) 5-Ethynyl-2'- deoxyuridine (EdU) assay conducted assess influence on cell proliferation vitro. In addition,...
Atherosclerosis (AS) is a major health problem and targeting the associated molecular pathways critical for developing therapies. The present study investigated effect of coptisine on human umbilical vein endothelial cells (HUVECs) in response to angiotensin II (Ang II) induction by focusing cellular senescence, apoptosis inflammation. HUVECs were treated with different Ang concentrations long non‑coding RNA small nucleolar host gene 12 (SNHG12), microRNA (miRNA/miR)‑603 nicotinamide...
Somatic mutations promote the transformation of normal cells to cancer. Accurate identification such facilitates cancer diagnosis and treatment, but biological technological noises, including intra-tumor heterogeneity, sample contamination, uncertainties in base sequencing read alignment, pose a big challenge somatic mutation discovery. A number callers have been developed predict them from paired tumor/normal or unpaired tumor data. However, small size currently available experimentally...
It is of considerable interest to detect somatic mutations in paired tumor and normal sequencing data. A number callers that are based on statistical or machine learning approaches have been developed small variants. However, they take into consideration only limited information about the reference potential variant allele both samples at a candidate site. Also, differ how biological technological noises addressed. Hence, expected produce divergent outputs. To overcome drawbacks existing...
ABSTRACT Objective Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, various physiological functions. In this study, we aimed to define spectrum COMs analysis its features or possible influencing factors improve surveillance control disease. Materials Methods We organized a multicenter survey from 19 hospitals in 14 provinces. The clinical data COM cases were collected...
Abstract Evidence from previous studies showed that the dysregulation of microRNA (miR) is frequently associated with tumor progression. The aberrant miR‐210 expression has been identified in a variety tumors. However, its biological roles esophageal squamous cell carcinoma (ESCC) still need further elucidation. Thus, current study we explore ESCC findings our reveal down‐regulated ESCC, which indicates poor prognosis and aggressive Moreover, restoration was found to enhance viability,...
The enteroinvasive bacterium Shigella flexneri is known as a highly host-adapted human pathogen. There had been no other reservoirs reported until recently. Here 34 isolates obtained from animals (yaks, dairy cows and beef cattle) 2016 to 2017 268 S. China were sequenced determine the relationships between animal infer evolutionary history of animal-associated flexneri. 18 (15 yak 3 cattle isolates) in PG1 separated into 4 lineages, 16 (1 yak, 5 10 cow PG3 clustered 8 lineages. most recent...
Abstract Background Somatic mutations promote the transformation of normal cells to cancer. Accurate identification such facilitates cancer diagnosis and treatment. A number callers have been developed predict them from paired tumor/normal or unpaired tumor sequencing data. However, small size currently available experimentally validated somatic sites limits evaluation then improvement callers. Fortunately, NIST reference material NA12878 genome has well-characterized with publicly...
Abstract Motivation It is of considerable interest to detect somatic mutations in paired tumor and normal sequencing data. A number callers that are based on statistical or machine learning approaches have been developed small variants. However, they take into consideration only limited information about the reference potential variant allele both samples at a candidate site. Also, differ how biological technological noises addressed. Hence, expected produce divergent outputs. Results To...
Research on the logo of catering enterprises, with enterprise culture, traditional environmental characteristics, characteristics products as theme positioning, and in-depth analysis Characteristics, elements use expression Logo enterprises.The results show that: enterprises should pay attention to innovative application Chinese pattern, mining cultural implications behind patterns, through modern design thinking computer technology for processing refining, create distinctive corporate...
Bioinformatics research on electricigens is the key process in microbial fuel cell(MFC) research.A variety of bioinformatics analysis methods have been applied this field.In review,the mainstream applications are summarized studies electricigen genome,functional genome and metabolic network,such as gene expression analysis,genome comparative analysis,metabolic network reconstruction silico simulation.Metabolic part between upstream downstream engineering,which also challenge current related...
Objective To investigate the expressions of matrix metalloproteinase-2 (MMP2) and tissue inhibitor MMP2 (TIMP2) in human malignant melanoma transplanted subcutaneously nude mice.Methods A non-sense oligonucleotide (N-ODN) an antisense oligodeoxynucleotide (ASODN)against heparanase mRNA were designed synthesized.Cultured A375 cells classified into 4 groups to be transfected with N-ODN,ASODN 10,20,30 μmol/L,respectively,via liposomes.The receiving no treatment served as blank control...