Abstract The circular RNA ciRS-7 has been reported to be involved in the pathogenesis of various tumors, including gastric and colorectal cancer. However, role esophageal squamous cell carcinoma (ESCC) remains unsolved. In this study, we found that expression was significantly upregulated ESCC cancer tissues compared with matched normal associated poor patient survival. Overexpression abrogated tumor-suppressive roles miR-7 proliferation, migration invasion vitro as well tumor growth lung...

As the first line of innate immune cells to migrate towards tumour tissue, neutrophils, can immediately kill abnormal and activate long-term specific adaptive responses. Therefore, enzymes mediated elevation reactive oxygen species (ROS) bioinspired by neutrophils be a promising strategy in cancer immunotherapy. Here, we design core-shell supramolecular hybrid nanogel via surface phosphatase triggered self-assembly oligopeptides around iron oxide nanoparticles simulate productive neutrophil...

Background Spinal cord injuries, often resulting from spine fractures, can lead to severe lifelong symptoms such as paraplegia and even mortality. Over the past few decades, there has been a concerning increase in annual incidence mortality rates of spinal which also placed growing financial strain on healthcare systems. This review aims offer comprehensive overview injuries by estimating their global incidence, prevalence, impact terms years lived with disability, using data obtained 2019...

Stromal cell-derived factor-1 (SDF-1) and its receptor, CXC chemokine receptor-4 (CXCR4), are important regulators in the migration of bone marrow mesenchymal stem cells (BMSCs). However, mechanisms underlying this effect acute pancreatitis (AP) have not been investigated. In study, BMSCs were identified by specific cell surface markers differentiation potentials, labeled with chloromethylbenzamido-1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (CM-Dil) for vivo tracking....

Abstract We have identified the most appropriate method of isolating human umbilical cord matrix‐derived mesenchymal stem cells (UCM‐MSCs) and compared morphological, phenotypic, proliferative differentiation characteristics UCM‐MSCs with bone marrow‐derived MSCs (BM‐MSCs) blood‐derived (UCB‐MSCs). Three explant culture methods three enzymatic were regards to time for primary culture, cell number, morphology, immune phenotype potential. Morphological, UCM‐MSCs, BM‐MSCs UCB‐MSCs also...

Abstract The administration of mesenchymal stem cells/multipotent stromal cells (MSCs) to enhance tissue repair is currently undergoing clinical trials. Some studies, including our previous work, have also revealed the beneficial effect MSCs in severe acute pancreatitis (SAP); however, their mechanisms or mode action remain controversial. In this study, we demonstrated that intravenously (i.v.)-administered human (hMSCs) remarkably promoted recovery from experimental SAP without significant...

Acute pancreatitis (AP) is a common acute abdominal disease, 10-20% of which can evolve into severe AP (SAP) causing significant morbidity and mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential repairing SAP, but detailed mechanism remains unknown. We demonstrate here that microRNA-9 (miR-9) modified BMSCs (pri-miR-9-BMSCs) significantly reduce pancreatic edema, infiltration, hemorrhage, necrosis, release amylase lipase. Meanwhile, decreased local/systemic...

Abstract Background Intestinal fibrosis is the final pathological outcome of chronic intestinal inflammation without specific therapeutic drugs, which leads to ileus and surgical intervention. characterized by excessive deposition extracellular matrix (ECM). The role mast cells (MCs), are members sentinel immune cell population, unknown in fibrosis. Methods In this study, we analyzed changes MCs, tryptase proteins, ECM components human fibrotic control patient intestines. We constructed...

Background Numerous studies have already identified an association between excessive consumption of red meat and colorectal cancer (CRC). However, there has been a lack detailed understanding regarding the disease burden linked to diet high in CRC. Objective We aim offer evidence-based guidance for developing effective strategies that can mitigate elevated CRC certain countries. Methods used data from Global Burden Disease (GBD) Study 2019 evaluate global, regional, national mortality rates...

Objective The objective of this study was to assess the global burden disease for developmental and intellectual disabilities caused by iodine deficiency from 1990 2019. Methods Using data (GBD) 2019, we conducted a cross-country inequity analysis examine worldwide issue Absolute relative inequality were assessed slope index concentration index, respectively. After summarising latest evidence, also projected age-standardized prevalence years lived with disability (YLD) rates up 2030 using...

Pinellia ternata (Thunb.) Breit is a widely used medicinal herb in Traditional Chinese Medicine (TCM). Still, its sustainable cultivation threatened by continuous cropping obstacles, which disrupt soil ecosystems, reduce yield, and degrade quality. Objectives: This study explores the potential of microbial inoculants to mitigate these challenges through integrated metabolomic transcriptomic analyses. Methods: Soil samples from fields with without issues were compare effects on secondary...

BACKGROUND: Chronic cerebral hypoperfusion-induced white matter lesions are an important cause of vascular cognitive impairment in aging life. TGF-β1 (transforming growth factor β1) is widely recognized as a multifunctional cytokine participating numerous pathophysiological processes the central nervous system. In this study, we aimed to evaluate neuroprotective potentials ischemic lesions. METHODS: A mouse model bilateral common carotid artery stenosis was established imitate The agonist...

Acute pancreatitis (AP), a common acute abdominal disease, 10%-20% of which can evolve into severe (SAP), is significant morbidity and mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) have been reported to potential therapeutic role on SAP, but the specific mechanism unclear. Therefore, we conducted this experiment shed light probable mechanism. We validated that SDF-1α significantly stimulated expressions VEGF, ANG-1, HGF, TGF-β, CXCR4 in BMSCs, were inhibited by its receptor...

Patients with chronic postsurgical pain (CPSP) frequently exhibit comorbid cognitive deficits. Recent observations have emphasized the critical effects of gut microbial metabolites, like short-chain fatty acids (SCFAs), in regulating function. However, underlying mechanisms and effective interventions remain unclear. According to hierarchical clustering 16S rRNA analysis, over two-thirds CPSP rats had impairment, impairment an aberrant composition SCFA-producing bacteria. Then, using feces...

Sterol carrier protein X (SCPx) is a 58-kDa that localized to peroxisomes. The amino acid sequence of the suggests SCPx may function as thiolase. gene encoding also codes for 15.3-kDa called sterol 2 (SCP2). Here we report structure this (SCP2), which spans approximately 80 kb and consists 16 exons 15 introns. Multiple transcription start sites were identified. 5′ flanking region has characteristics other peroxisomal promoters, include absence TATA box G+C-enriched containing several reverse...

Abstract Mast cells (MCs) are potent tissue-resident immune that distributed in the intraepithelial space of intestine and have been implicated regulating homeostasis coordinating epithelial responses inflamed mucosa inflammatory bowel disease (IBD). IL-33 functions as an endogenous danger signal or alarmin segments. MCs highly express receptor ST2. However, mechanisms underlying regulation MC-dependent IL-33/ST2 signaling at barrier surface remain largely unknown. We confirmed required for...

It was well known that cancer-associated fibroblasts (CAFs) were an essential factor in tumor progression. However, the actual mechanism of stromal activation and promoting effects remain unclear. Here, we showed KLF5 expression more frequently observed gastric compared with normal mucosal fibroblasts. Moreover, stroma closely associated clinicopathological features such as size, invasion depth, cell grade lymph node metastasis, poor prognosis patients cancer. In addition, further...

Early identification and timely therapeutic strategies for potential critical patients with coronavirus disease 2019 (COVID-19) are of crucial importance to reduce mortality. We aimed develop validate a prediction tool 30-day mortality these on admission.

Abstract Background Hepatic ischemia–reperfusion injury (HIRI) is a common complication of liver surgery, which can lead to extrahepatic metabolic disorders, such as cognitive impairment. Recent observations have emphasized the critical effects gut microbial metabolites in regulating development injury. Herein, we investigated potential contribution microbiota HIRI-related Methods HIRI murine models were established by surgery morning (ZT0, 08:00) and evening (ZT12, 20:00), respectively....