A5051821019- Liquid Crystal Research Advancements
- Spine and Intervertebral Disc Pathology
- Photonic Crystals and Applications
- Healthcare and Venom Research
- Synthesis and biological activity
- Transition Metal Oxide Nanomaterials
- Acupuncture Treatment Research Studies
- Silicone and Siloxane Chemistry
- Advanced battery technologies research
- Mast cells and histamine
- Photonic and Optical Devices
- Medical Imaging and Analysis
- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Spinal Cord Injury Research
- Pain Mechanisms and Treatments
- Cancer Cells and Metastasis
- Cervical and Thoracic Myelopathy
- PI3K/AKT/mTOR signaling in cancer
- Anesthesia and Pain Management
- Cancer-related Molecular Pathways
- Supercapacitor Materials and Fabrication
- Milk Quality and Mastitis in Dairy Cows
- Advancements in Battery Materials
- Photochromic and Fluorescence Chemistry
Jiangsu Province Hospital
2018-2025
Nanjing Medical University
2018-2025
Xinjiang Medical University
2016-2024
Zhejiang University
2024
Inner Mongolia University
2021-2023
Xijing University
2021-2023
Fudan University
2019-2022
Texas Tech University Health Sciences Center
2020
Texas Tech University
2020
Huashan Hospital
2019
Glioma is still difficult to treat because of its high malignancy, recurrence rate, and resistance anticancer drugs. An alternative method for research gliomagenesis drug use in vitro tumor model that closely mimics the vivo microenvironment. In this study, we established a 3D bioprinted glioma stem cell model, using modified porous gelatin/alginate/fibrinogen hydrogel extracellular matrix. cells achieved survival rate 86.92%, proliferated with cellular activity immediately following...
As the first line of innate immune cells to migrate towards tumour tissue, neutrophils, can immediately kill abnormal and activate long-term specific adaptive responses. Therefore, enzymes mediated elevation reactive oxygen species (ROS) bioinspired by neutrophils be a promising strategy in cancer immunotherapy. Here, we design core-shell supramolecular hybrid nanogel via surface phosphatase triggered self-assembly oligopeptides around iron oxide nanoparticles simulate productive neutrophil...
The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) unclear. In this study, expression levels were found to be positively correlated with the severity human IVDD. mouse tail suspension (TS)-induced IVDD model, lumbar height index matrix protein reduced significantly largely rescued by deletion. TS discs, reactive oxygen species levels, proportions senescent cells, senescence-associated secretory...
Ligamentum flavum (LF) hypertrophy (LFH) has been recognised as one of the key contributors to lumbar spinal stenosis. Currently, no effective methods are available ameliorate this hypertrophy. In study, human umbilical cord mesenchymal stromal cell-derived extracellular vesicles (hUCMSC-EVs) were introduced for first time promising vehicles drug delivery treat LFH. The downregulation miR-146a-5p and miR-221-3p expressions in LF tissues negatively correlated with increased thickness....
Abstract Glioma stem cells (GSCs) are thought to be the root cause of tumor recurrence and drug resistance in glioma patients. In‐depth study GSCs is great significance for developing treatment strategies glioma. Unfortunately, it difficult takes complicated process obtain GSCs. Therefore, establishing an ideal vitro model enriching will greatly promote In this study, stemness properties were enhanced three‐dimensional (3D) bioprinted model. Furthermore, possible molecular mechanism...
Intervertebral disk degeneration (IDD) is a major cause of low back pain that becomes prevalent age-related disease. However, the pathophysiological processes behind IDD are rarely known. Here, we used bioinformatics analysis based on microarray datasets (GSE34095) to identify differentially expressed genes (DEGs) as biomarkers and therapeutic targets in degenerated discs. From previous studies, oxidative stress has been notified positive inducement IDD, which causes DNA damage accelerates...
Probiotics are gaining attention due to their functions of regulating the intestinal barrier and promoting human health. The production exopolysaccharide (EPS) is one important factors for probiotics exert beneficial properties. This study aimed screen exopolysaccharides-producing lactic acid bacteria (LAB) evaluate probiotic potential. we obtained three fractions (EPS1, EPS2, EPS3) from Lactobacillus pantheris TCP102 purified by a combination ion-exchange chromatography gel permeation...
Osteoarthritis (OA) is a leading cause of pain, disability, and reduced mobility worldwide, characterized by metabolic imbalances in chondrocytes, extracellular matrix (ECM), subchondral bone. Emerging evidence highlights the critical role long non-coding RNAs (lncRNAs) OA pathogenesis. This study focuses on lncRNA PTS-1, novel lncRNA, to explore its function regulatory mechanisms progression. The expression profile lncRNAs was assessed using RNA sequencing qRT-PCR. lnc-PTS-1 further...
In this work, two silicon nanostructures were doped into polymer/nematic liquid crystal composites to regulate the electric-optical performance. Commercial SiO2nanoparticles and synthesized thiol polyhedral oligomeric silsesquioxane (POSS-SH) chosen as dopants afford nanostructures. physically dispersed in nanostructure from POSS-SH was implanted polymer matrix of via photoinduced thiol-ene crosslinking. Scanning electron microscopy results indicated that implantation POSS microstructure...
This work aims to elucidate the effects and potential underlying mechanisms of microRNA-216a-3p (miR-216a-3p) on proliferation, migration, invasion gastric cancer (GC) cells. In this study, we revealed that expression miR-216a-3p was significantly elevated in GC tissues cell lines. The different level firmly correlated with clinicopathological characteristics patients. We next demonstrated upregulation could dramatically promote ability cells using a series experiments, whereas...
To evaluate the curative efficacy by comparing perioperative characteristics and 1.5-year observational outcomes in 1-segment lumbar spondylolisthesis between traditional minimally invasive transforaminal interbody fusion (MIS-TLIF) optimized Endoscopic TLIF techniques.The study was a single-center, randomized controlled trial two different treatment approaches for spondylolisthesis. 102 patients treated MIS-TLIF (48 cases) or Endo-TLIF (54 were included from March 2018 to April 2019....
Purpose: Both percutaneous endoscopic lumbar discectomy (PELD) and open fenestration (OFD) are effective safe surgical procedures for the treatment of LDH. The purpose this retrospective study was to compare outcomes interlaminar (PEID) OFD single-segment huge disc herniation (HLDH). Patients Methods: We retrospectively analyzed 91 patients diagnosed with HLDH treated or PEID. Visual analog scale (VAS), modified Japanese orthopedic association (mJOA) Oswestry disability index (ODI) were used...