A5081693504- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Cervical and Thoracic Myelopathy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Circular RNAs in diseases
- Musculoskeletal pain and rehabilitation
- Cardiovascular Effects of Exercise
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
- Anesthesia and Pain Management
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Medical Imaging and Analysis
- Spinal Hematomas and Complications
- Adenosine and Purinergic Signaling
- Sleep and Wakefulness Research
- Scoliosis diagnosis and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiomyopathy and Myosin Studies
- Protease and Inhibitor Mechanisms
- Cardiac Arrhythmias and Treatments
- PARP inhibition in cancer therapy
University of Tsukuba
2016-2024
Xuzhou Medical College
2012-2024
Lianyungang Oriental Hospital
2021-2024
Huadong Sanatorium
2023
Nanjing Medical University
2021-2023
Huadong Hospital
2023
The First People’s Hospital of Lianyungang
2012-2022
Jiangsu Province Hospital
2021
Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, inflammatory response. However, little is about the effect of agonist on progression myocardial infarction (MI) heart failure. To investigate it, wild-type male mice underwent sham-operation or permanent ligation left anterior descending coronary artery to create MI model. SR9009 (100 mg/kg/day) vehicle was intraperitoneally administered. Echocardiography performed evaluate...
Spinal cord injury (SCI) is a devastating neuropathological condition. Long noncoding RNA X-inactive specific transcript (XIST) an acknowledged cancer-related gene and participates in the development of SCI. However, role XIST SCI remains to be well revealed. Expression XIST, miRNA-27a-3p (miR-27a) smad ubiquitination regulatory factor 1 (Smurf1) was detected using RT-qPCR western blotting. Cell apoptosis inflammatory were assessed by sulforhodamine B (SRB) assay, flow cytometry, blotting...
Aim: The aim of this study is to assess the long-term clinical and radiological outcomes between minimally invasive (MIS) conventional transforaminal lumbar interbody fusion (TLIF) in treating one-segment disc herniation (LDH).Material methods: One-hundred six patients treated by MIS-TLIF (50 cases) or TLIF (56 were included. Perioperative results evaluated. Clinical compared preoperatively postoperatively. Radiologic parameters based on a comparison preoperative three-year postoperative...
Abstract Anterior reduction and interbody fusion fixation has not been compared directly with posterior short-segmental pedicle screw for lower cervical dislocation, so consensus is lacking as to which the optimal method. The purpose of this paper compare long-term outcomes anterior versus approach traumatic dislocation spinal cord injury. One hundred fifty-nine patients could be followed more than 10 years (follow-up rate 84.1%). Ninety-two underwent fixation, 67 fixation. Japanese...
To evaluate the early clinical effect of percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF) and minimally invasive (MIS-TLIF) surgery in treatment middle-aged elderly patients with single-level disc herniation accompanied by instability. From January 2019 to June 2020, a total 82 consecutive were categorised into PE-TLIF group MIS-TLIF based on different surgical methods. The visual analog scale (VAS), Oswestry disability index (ODI), Japanese Orthopaedic Association...
Microendoscopic discectomy (MED) and percutaneous transforaminal endoscopic (PTED) are 2 of the most popular minimally invasive spinal surgery techniques. We investigating whether early annular closure can achieve a better clinical effect in treatment lumbar disc herniation (LDH).
To evaluate the curative efficacy by comparing perioperative characteristics and 1.5-year observational outcomes in 1-segment lumbar spondylolisthesis between traditional minimally invasive transforaminal interbody fusion (MIS-TLIF) optimized Endoscopic TLIF techniques.The study was a single-center, randomized controlled trial two different treatment approaches for spondylolisthesis. 102 patients treated MIS-TLIF (48 cases) or Endo-TLIF (54 were included from March 2018 to April 2019....
Exercise can improve morbidity and mortality in heart failure patients; however, the underlying mechanisms remain to be fully investigated. Thus, we investigated effects of exercise on cardiac function ventricular arrhythmias myocardial infarction (MI) induced mice. Wild-type male mice underwent sham-operation or permanent left coronary artery ligation induce MI. MI were divided into a sedentary (MI-Sed) two intervention groups: MI-Ex (underwent 6-week treadmill training) MI-βb (oral...
MicroRNAs (miRs) play an important role in the development and progression of spinal cord injury (SCI). The miR‑138‑5p SCI was investigated present study. anti‑inflammatory effects underlying mechanisms were rat model vitro model. Reverse transcription‑quantitative PCR (RT‑qPCR) used to examine expression vivo models, as well patients with SCI; it found that significantly upregulated SCI. Bioinformatics dual‑luciferase reporter assays performed predict confirm binding sites between...
Aging and obesity are the most prominent risk factors for onset of atrial fibrillation (AF). Nicotinamide phosphoribosyltransferase (Nampt) is rate-limiting enzyme that catalyzes nicotinamide adenine dinucleotide (NAD) activity. Nampt NAD essential maintenance cellular redox homeostasis modulation metabolism, their expression levels decrease with aging obesity. However, a role in AF unknown. The present study aims to test whether there Nampt/NAD axis pathogenesis obesity-induced AF. Male...
Inherited arrhythmia syndromes (IASs) can cause life-threatening arrhythmias and are responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress in the development devices to prevent SCDs, precise molecular mechanisms that induce detrimental remain be fully investigated, more effective therapies desirable. In present study, we screened large-scale randomly mutagenized mouse library by electrocardiography establish disease model IASs consequently found one...
Spinal cord injury (SCI) is a devastating traumatic condition accompanied with excessive inflammatory response and apoptosis of microglia. Long noncoding RNAs (lncRNAs) have been confirmed to be key regulators cell response. Nevertheless, the role lncRNA KCNQ1OT1 in microglia or after SCI remains explored. Our study focused on exploring mechanism SCI. RT-qPCR showed that induced increase level mice spinal cord. Inhibition suppressed In addition, was proved bind miR-589-5p, NPTN directly...
China has established a goal of reducing adult smoking prevalence from 27.7% to 20% by 2030. Understanding the possible ongoing impairment in lung function smokers, is critically important encourage populations change their behavior.A total 14,273 males joined health examination at Huadong Sanatorium Jan 2012 Dec 2019 were included. In cross-sectional analysis, we used multiple linear regression evaluate association between baseline and status. Then, 3,558 who received ≥2 spirometry exams...
Ventilation (VE) increases linearly with the increase of carbon dioxide output (VCO2) during cardiopulmonary exercise testing. VE-VCO2 slope rises in parallel intensity, reaches a turning point (called RC point), then steepens because respiratory compensation for lactic acidosis. While this can be identified universally, it is undetectable some patients. In study we evaluated whether testing has clinical significance cardiac total, 152 patients exchange ratio at peak (peak R) between 1.10...
BACKGROUND This study from a single center aimed to compare short-term patient outcomes the Interlaminar Endoscopic Surgical System iLESSYS® Delta system vs bilateral laminotomy in 80 patients with degenerative lumbar spinal stenosis (DLSS). MATERIAL AND METHODS We selected DLSS for study. Of these, 40 were treated and laminotomy. followed these 1 year. recorded compared data on incision length, operation time intraoperative blood loss, hospitalization time, postoperative complications,...