A5064041037- Sleep and Wakefulness Research
- Adenosine and Purinergic Signaling
- Photoreceptor and optogenetics research
- Bone health and osteoporosis research
- Cervical Cancer and HPV Research
- Neuroscience and Neuropharmacology Research
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Vagus Nerve Stimulation Research
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Retinopathy of Prematurity Studies
- Head and Neck Cancer Studies
- Cerebrospinal fluid and hydrocephalus
- Analytical Methods in Pharmaceuticals
- Photochromic and Fluorescence Chemistry
- Magnolia and Illicium research
- Analytical Chemistry and Chromatography
- Inflammatory mediators and NSAID effects
- Hematological disorders and diagnostics
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- DNA and Nucleic Acid Chemistry
Tsukuba International University
2018-2024
University of Tsukuba
2018-2024
Affiliated Eye Hospital of Wenzhou Medical College
2023-2024
Wenzhou Medical University
2015-2024
Zhejiang Lab
2023-2024
Wenzhou Central Hospital
2015
Fudan University
2012
First Affiliated Hospital of Chengdu Medical College
2001
Abstract Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of neurochemical underpinning hampered its therapeutic development. Here, we demonstrate that flickering triggered an immediate and sustained increase (up 3 h after flickering) in extracellular adenosine levels primary visual cortex (V1) other brain regions, function frequency intensity, with maximal effects observed at 40 Hz 4000...
Major depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum (LS) is thought to control depression, however, cellular circuit substrates largely unknown. Here, we identified subpopulation LS GABAergic adenosine A
Abstract The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of brain milieu since it defines cerebral spinal fluid flow in parenchyma and eliminates metabolic waste. Animal human studies have uncovered several important physiological factors regulating glymphatic including sleep, aquaporin-4, hemodynamic factors. Yet, our understanding modulation limited, which has hindered development glymphatic-based treatment aging neurodegenerative disorders....
Optochemistry, an emerging pharmacologic approach in which light is used to selectively activate or deactivate molecules, has the potential alleviate symptoms, cure diseases, and improve quality of life while preventing uncontrolled drug effects. The development in-vivo applications for optochemistry render brain cells photoresponsive without relying on genetic engineering been progressing slowly. nucleus accumbens (NAc) a region regulation slow-wave sleep (SWS) through integration...
Sleep–wake behavior is controlled by a wide range of neuronal populations in the mammalian brain. Although ventral midbrain/pons (VMP) area suggested to participate sleep–wake regulation, mechanisms have remained unclear. Here, we found that nonspecific cell ablation or selective GABAergic neurons expressing diphtheria toxin fragment A VMP male mice induced large increase wakefulness lasted at least 4 weeks. In contrast, dopaminergic had little effect on wakefulness. Chemogenetic inhibition...
Social conflict is a major source of stress in humans. Animals also experience social conflicts and cope with them by responses that facilitate arousal activate sympathetic neuroendocrine systems. The effect acute defeat (SoD) on the sleep/wake behavior mice has been reported several models based resident-intruder paradigm. However, post-SoD effects vary between studies contribution specific response to SoD or non-specific procedure (e.g., sleep deprivation) not well established. In this...
An ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of tenacissoside G, H, and I in rat plasma. The plasma treated with liquid-liquid extraction using ethyl acetate. performed on UPLC HSS T3 column (50 mm × 2.1 mm, 1.8 μm) a mobile phase consisting acetonitrile-water (containing 0.1% formic acid) gradient elution at flow rate 0.4 mL/min. Electrospray (ESI) positive ion mode detection multireaction monitoring (MRM)...
Purpose: To explore dosimetric effects of brainstem (BS) caused by weight loss during the course intensity‐modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC). Methods: Seventy‐seven patients who were diagnosed with NPC pathology biopsy have been enrolled. Every should receive measurement weekly and three times computed tomography (CT) scans replanning, at 15th 25th fraction treatment, respectively. The vertical diameter level odontoid process (d1) cervical vertebra 3 (d2)...
Abstract Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of neurochemical underpinning hampered its therapeutic development. Here, we demonstrate that flickering triggered an immediate and sustained increase (up 3 hours after flickering) in extracellular adenosine levels primary visual cortex other brain regions, function frequency, intensity, wavelength, with maximal effects observed at...
Abstract An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of monocrotaline and usaramine in rat plasma, to study plasma drug concentration pharmacokinetics, calculate absolute bioavailability. The treated with acetonitrile methanol (9:1, v/v) protein precipitation method. chromatographic column UPLC HSS T3 (50 mm × 2.1 mm, 1.7 μm), mobile phase methanol-water (containing 0.1% formic acid 10 mM ammonium acetate water),...
Abstract Depression is the single largest contributor to burden of disease, yet current antidepressant medications are limited by high non-responsiveness and significant side effects. The lateral septum (LS) thought control depression, however, cellular circuit substrates largely unknown. Here, we identified a subpopulation LS GABAergic adenosine A2A receptors (A2AR)-positive neurons mediating depression via direct projects habenula (LHb) hypothalamus. Activation A2AR in augmented spiking...