A5064269829- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrolyte and hormonal disorders
- Erythrocyte Function and Pathophysiology
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Vagus Nerve Stimulation Research
- Cerebrospinal fluid and hydrocephalus
- Ion Transport and Channel Regulation
- Connexins and lens biology
- Oral and Maxillofacial Pathology
- Materials Engineering and Processing
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Bone Tumor Diagnosis and Treatments
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Hemostasis and retained surgical items
- Phagocytosis and Immune Regulation
University of Coimbra
2020-2025
Universidade Estadual de Montes Claros
2012
Abstract The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of brain milieu since it defines cerebral spinal fluid flow in parenchyma and eliminates metabolic waste. Animal human studies have uncovered several important physiological factors regulating glymphatic including sleep, aquaporin-4, hemodynamic factors. Yet, our understanding modulation limited, which has hindered development glymphatic-based treatment aging neurodegenerative disorders....
ABSTRACT Astrocytes participate in brain clearance of extracellular proteins and metabolites, through the activity water channel aquaporin‐4 (AQP4), which can be deregulated stress‐related disorders, impairing waste clearance. The present study investigates impact dexamethasone (Dexa), a synthetic glucocorticoid used as simplified vitro stress model, on astrocytic AQP4 its modulation by adenosine A 2A receptors (A R), blockade reverses conditions related with maladaptive stress, such anxiety...
Depressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P 2X7 receptors (P R) and adenosine A 2A (A antagonists attenuate behavioral modifications upon exposure to stress. Since it is unknown if these two purinergic modulation systems work independently, we now investigated putative interplay between P R R. Adult rats exposed restraint for 14 days displayed an anxious (thigmotaxis, elevated plus maze),...
Increased ATP release and its extracellular catabolism through CD73 (ecto-5′-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood memory dysfunction caused by repeated stress, but it is unknown if increased coupled CD73-mediated formation responsible for upon stress. This was now investigated adult rats subject stress 14 consecutive days. Frontocortical hippocampal synaptosomes from stressed displayed...
To identify and quantify mast cell (MC), vascular endothelial growth factor (VEGF) expression microvessel density (MVD) in human periapical cysts granulomas.Archived samples of (n = 40) granulomas 28) were sectioned stained with toluidine blue. MCs identified counted. Immunohistochemical reactions employed to evaluate the tissue VEGF vessels. MVD was estimated by determining areas labelled CD31 antibody. The data analysed using Mann-Whitney test (P < 0.05).MCs observed peripheral regions...
Background and Objective Stress anxiety have been associated with chronic periodontitis, but few studies examining the effects of psychotropic drugs on periodontal health performed. Therefore, we aimed to investigate diazepam progression periodontitis in chronically stressed rats. Material Methods Fourteen W istar rats were submitted ligature‐induced disease divided into four groups . Two not stressed, whereas two a conditioned fear stress paradigm for 38 d. Daily treatment (2 mg/kg, orally)...