A5087287145- HIV Research and Treatment
- Urticaria and Related Conditions
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ocular Surface and Contact Lens
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Corneal Surgery and Treatments
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Corneal surgery and disorders
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Atrial Fibrillation Management and Outcomes
- Cytomegalovirus and herpesvirus research
- Cancer Research and Treatments
- Pancreatic function and diabetes
Capital Medical University
2012-2025
Yan'an University
2024-2025
Affiliated Hospital of Guizhou Medical University
2022-2025
Guiyang Medical University
2022-2025
Soochow University
2009-2025
Southern Medical University
2014-2025
Nanjing Forestry University
2025
Beijing Tongren Hospital
2009-2024
State Key Laboratory of Molecular Oncology
2024
Xiangya Hospital Central South University
2017-2024
Familial advanced sleep phase syndrome (FASPS) is an autosomal dominant circadian rhythm variant; affected individuals are "morning larks" with a 4-hour advance of the sleep, temperature, and melatonin rhythms. Here we report localization FASPS gene near telomere chromosome 2q. A strong candidate (hPer2), human homolog period in Drosophila, maps to same locus. Affected have serine glycine mutation within casein kinase Iepsilon (CKIepsilon) binding region hPER2, which causes...
Lung cancer has long been the most dangerous malignant tumor among males in both well developed and poorly countries. Radiotherapy plays a critical role curative management of inoperable non-small cell lung (NSCLC) is also used as post-surgical treatment patients. Radioresistance an important factor that limits efficacy radiotherapy for NSCLC Increasing evidence suggests microRNAs (miRNAs) possess diverse cellular regulatory roles radiation responses. In this study, we miRNA microarray...
This study aimed to determine the mutational spectrum of familial Parkinson's disease and sporadic early-onset (sEOPD) in a mainland Chinese population clinical features mutation carriers. We performed multiplex ligation-dependent probe amplification assays whole-exome sequencing for 1676 unrelated patients with population, including 192 probands from families autosomal-recessive disease, 242 autosomal-dominant 1242 sEOPD (age at onset ≤ 50). According standards guidelines American College...
Abstract Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of neurochemical underpinning hampered its therapeutic development. Here, we demonstrate that flickering triggered an immediate and sustained increase (up 3 h after flickering) in extracellular adenosine levels primary visual cortex (V1) other brain regions, function frequency intensity, with maximal effects observed at 40 Hz 4000...
Hepatocellular carcinoma (HCC) is the fifth most common malignancy caused by environmental and genetic factors. MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. They participate in diverse biological pathways function as gene regulators. Genetic polymorphisms 3′ untranslated regions (3′ UTRs) targeted miRNAs alter strength miRNA binding, consequences on regulation target genes thereby affecting individual's cancer risk. We have previously...
Abstract The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of brain milieu since it defines cerebral spinal fluid flow in parenchyma and eliminates metabolic waste. Animal human studies have uncovered several important physiological factors regulating glymphatic including sleep, aquaporin-4, hemodynamic factors. Yet, our understanding modulation limited, which has hindered development glymphatic-based treatment aging neurodegenerative disorders....
Background and Objective: Olfactory dysfunction (hyposmia) is an important non-motor symptom of Parkinson’s disease (PD). To investigate the potential prognostic value hyposmia as a marker for progression, we prospectively assessed clinical manifestations longitudinal changes hyposmic PD patients normosmic ones. Methods function was evaluated with Sniffin’ Sticks in at baseline. One hundred five 59 were enrolled followed up 2 years. They subsequently baseline during follow-up periods...
Phosphoglycerate kinase 1 (PGK1) serves as a pivotal enzyme in the cellular glycolysis pathway, facilitating adenosine-triphosphate (ATP) production tumor cells and driving Warburg effect. PGK1 generates ATP through reversible phosphorylation reaction of 1,3-bisphosphoglycerate (1,3-BPG) to Mg-adenosine-5′-diphosphate (Mg-ADP). In addition its role regulating metabolism, plays autophagy induction, regulation tricarboxylic acid cycle (TCA), various mechanisms including cell drug resistance,...
N-glycans play an essential role in biological process and are associated with age, gender, body mass parameters Caucasian populations, whereas no study has been reported Chinese populations. To investigate the correlation between N-glycan structures metabolic syndrome (MetS) components, we conducted a population-based 212 Han individuals. The replication was performed on 520 unrelated individuals from Croatian island Korčula. most prominent observation consistent positive correlations...
Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source increased tumor-infiltrating remains poorly understood. We investigated prevalence, phenotype trafficking property in patients cancer. results showed highly aggregated an activated markedly expression CCR6. Correspondingly, level CCL20 was significantly higher than non-tumor normal control tissues, strongly positively associated cells....
Abstract Background Common and rare variants of guanosine triphosphate cyclohydrolase 1 ( GCH1 ) gene may play important roles in Parkinson’s disease (PD). However, there is a lack comprehensive analysis genotypes, especially non-coding regions. The aim this study was to explore the genetic characteristics , including common coding regions, large population PD patients Chinese mainland, as well phenotypic variant carriers. Methods In first cohort case-control study, we performed whole-exome...
Although M2 macrophages are involved in the orchestration of type 2 inflammation allergic diseases, mechanisms underlying non-coding RNA (ncRNA)-mediated macrophage polarization rhinitis (AR) have not been systematically understood. Here, we identified long (lncRNA) MIR222HG as a key regulator and revealed its role AR. Consistent with our bioinformatic analysis GSE165934 dataset derived from Gene Expression Omnibus (GEO) database, lncRNA-MIR222HG murine mir222hg were downregulated clinical...
The aim of the present study was to investigate association between cell-free DNA (cf-DNA) levels and clinicopathological characteristics patients with ovarian cancer using a branched (bDNA) technique, determine value quantitative cf-DNA detection in assisting diagnosis cancer. Serum specimens were collected from 36 on days 1, 3 7 following surgery, additional serum samples also 22 benign tumor cases, 19 healthy, non-cancerous ovaries. bDNA techniques used detect concentrations. All data...
Upper limb lymphedema is a common complication after radical mastectomy in patients with breast cancer. In this study, we examined the efficacy of self-manual lymph drainage (MLD) modified for prevention upper lymphedema, scar formation, or shoulder joint dysfunction cancer patients.Breast scheduled were randomly apportioned to undergo physical exercise only (PE group, control; n = 500) self-MLD as well (MLD group; surgery. PE started undertake remedial exercises and progressive weight...
Translating from Chinese into another language or vice versa is becoming a widespread phenomenon.However, current neuroimaging studies are insufficient to reveal the neural mechanism underlying translation asymmetry during Chinese/English sight translation.In this study, functional near infrared spectroscopy (fNIRS) was used extract brain activation patterns associated with translation.Eleven unbalanced (L1)/English (L2) bilinguals participated in study based on an intragroup experimental...