A5064299667- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Salivary Gland Disorders and Functions
- Gut microbiota and health
- Immune responses and vaccinations
- Adenosine and Purinergic Signaling
- Periodontal Regeneration and Treatments
- Receptor Mechanisms and Signaling
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Medical Imaging and Analysis
- Immune cells in cancer
- Oral Health Pathology and Treatment
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Meningioma and schwannoma management
- S100 Proteins and Annexins
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Intensive Care Unit Cognitive Disorders
Zhejiang University
2023-2024
Stomatology Hospital
2023-2024
Zhejiang Chinese Medical University
2023-2024
Peking University
2024
Peking University Third Hospital
2024
Zhejiang University Medical College Affiliated Stomatological Hospital
2024
Affiliated Eye Hospital of Wenzhou Medical College
2019-2023
Wenzhou Medical University
2019-2023
First Affiliated Hospital Zhejiang University
2023
Photodynamic therapy (PDT) and photothermal therapies (PTTs) are both promising strategies for effective tumor therapy. However, the absence of O2 at sites hinders sustained response photosensitizers. Here, we develop a recycled cerium oxide (CeO2) catalase nanozyme-loaded hyaluronic acid nanovesicle to address hypoxic microenvironments targeted delivery photosensitizers [indocyanine green (ICG)] tumors. A polysaccharide complex effectively modifies surface polyethylenimine phenylboronic...
Major depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum (LS) is thought to control depression, however, cellular circuit substrates largely unknown. Here, we identified subpopulation LS GABAergic adenosine A
Abstract Background Recent research has established the correlation between gut microbiota and periodontitis via oral-gut axis. Intestinal dysbiosis may play a pivotal bridging role in extra-oral inflammatory comorbidities caused by periodontitis. However, it is unclear whether link merely correlative or orchestrated causative mechanistic interactions. This two-sample Mendelian randomization (MR) study was performed to evaluate potential bidirectional causal relationships Materials Methods A...
Periodontitis drives irreversible destruction of periodontal tissue and is prone to exacerbating inflammatory disorders. Systemic immunomodulatory management continues be an attractive approach in care, particularly within the context ‘predictive, preventive, personalized’ periodontics. The present study incorporated genetic proxies identified through genome-wide association studies for circulating immune cells periodontitis into a comprehensive Mendelian randomization (MR) framework....
Abstract In tumor therapeutics, the transition from conventional cytotoxic drugs to targeted molecular therapies, such as those targeting receptor tyrosine kinases, has been pivotal. Despite this progress, clinical outcomes have remained modest, with glioblastoma patients' median survival stagnating at less than 15 months. This underscores urgent need for more specialized treatment strategies. Our review delves into progression toward immunomodulation in glioma treatment. We dissect critical...
Periodontitis drives irreversible destruction of periodontal tissue and is prone to exacerbating inflammatory disorders. Systemic immunomodulatory management continues be an attractive approach in care, particularly within the context ‘predictive, preventive, personalized’ periodontics. The present study incorporated genetic proxies identified through genome-wide association studies for circulating immune cells periodontitis into a comprehensive Mendelian randomization (MR) framework....
The deficits of cognitive flexibility (including attentional set-shifting and reversal learning) concomitant with dysfunction the striatum are observed in several neuropsychiatric disorders. Rodent human studies have identified [particularly dorsomedial (DMS) nucleus accumbens (NAc)] as critical locus for control flexibility, but effective neuromodulator pharmacological remains to be determined. adenosine A2A receptors (A2ARs) highly enriched striatopallidal neurons where they integrate...
Abstract Background Recent studies have found that there is a certain correlation between gut microbiota (GM) and oral cavity cancer (OCC). However, their causality unclear. This study aimed to evaluate the causal relationship GM OCC identify specific pathogenic microbial taxa. Materials Methods In this Two-Sample Mendelian Randomization Study,GWAS of microbiome from MiBioGen consortium (18,340 samples 24 population-based cohorts) were used as exposure data. addition, outcome data (357 cases...
Periodontitis drives irreversible destruction of periodontal tissue and is prone to exacerbating inflammatory disorders. Systemic immunomodulatory management continues be an attractive approach in care, particularly within the context "predictive, preventive, personalized" periodontics. In present study, genetic proxies identified through genome-wide association studies (GWAS) for circulating immune cells periodontitis were incorporated into a comprehensive Mendelian randomization (MR)...
Abstract Periodontitis drives irreversible destruction of periodontal tissue and is prone to exacerbating inflammatory disorders. Systemic immunomodulatory management continues be an attractive approach in care, particularly within the context "predictive, preventive, personalized" periodontics. In present study, genetic proxies identified through genome-wide association studies (GWAS) for circulating immune cells periodontitis were incorporated into a comprehensive Mendelian randomization...
Periodontitis drives irreparable destruction of periodontal tissue and possesses a tendency to aggravate inflammatory disorders. Systemic immunomodulation management remains an attractive approach in care within context “predictive, preventive, personalized” periodontics. Leveraging comprehensive Mendelian randomization (MR), the present study aims evaluate causal relationships between circulating immune cells risk periodontitis.Genetic proxies for periodontitis were obtained from...
Abstract Depression is the single largest contributor to burden of disease, yet current antidepressant medications are limited by high non-responsiveness and significant side effects. The lateral septum (LS) thought control depression, however, cellular circuit substrates largely unknown. Here, we identified a subpopulation LS GABAergic adenosine A2A receptors (A2AR)-positive neurons mediating depression via direct projects habenula (LHb) hypothalamus. Activation A2AR in augmented spiking...