A5072825307- Adenosine and Purinergic Signaling
- Sleep and Wakefulness Research
- Neuropeptides and Animal Physiology
- Sleep and related disorders
- Vagus Nerve Stimulation Research
- Pharmacological Receptor Mechanisms and Effects
- Photochromic and Fluorescence Chemistry
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
Tsukuba International University
2018-2024
University of Tsukuba
2018-2024
Optochemistry, an emerging pharmacologic approach in which light is used to selectively activate or deactivate molecules, has the potential alleviate symptoms, cure diseases, and improve quality of life while preventing uncontrolled drug effects. The development in-vivo applications for optochemistry render brain cells photoresponsive without relying on genetic engineering been progressing slowly. nucleus accumbens (NAc) a region regulation slow-wave sleep (SWS) through integration...
Background: Insomnia is associated with psychiatric illnesses such as bipolar disorder or schizophrenia. Treating insomnia improves psychotic symptoms severity, quality of life, and functional outcomes. Patients disorders are often dissatisfied the available therapeutic options for their insomnia. In contrast, positive allosteric modulation adenosine A 2A receptors (A Rs) leads to slow-wave sleep without cardiovascular side effects in contrast R agonists. Methods: We investigated hypnotic...