A5086384018- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Sleep and Wakefulness Research
- Food Industry and Aquatic Biology
- Cytomegalovirus and herpesvirus research
- Adenosine and Purinergic Signaling
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Food composition and properties
- Atrial Fibrillation Management and Outcomes
- Protease and Inhibitor Mechanisms
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
- Neurological Complications and Syndromes
- Vagus Nerve Stimulation Research
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- S100 Proteins and Annexins
- Protein Hydrolysis and Bioactive Peptides
- Phytase and its Applications
- Advanced Glycation End Products research
- Surgical site infection prevention
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Diseases and Immunity
First Affiliated Hospital of Jinan University
2025
Jinan University
2025
Union Hospital
2022
Huazhong University of Science and Technology
2022
University of Tsukuba
2017-2021
Beijing Chao-Yang Hospital
2016
Capital Medical University
2016
Anshan Hospital
2012
Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, inflammatory response. However, little is about the effect of agonist on progression myocardial infarction (MI) heart failure. To investigate it, wild-type male mice underwent sham-operation or permanent ligation left anterior descending coronary artery to create MI model. SR9009 (100 mg/kg/day) vehicle was intraperitoneally administered. Echocardiography performed evaluate...
Neutrophils are recruited into the heart at an early stage following a myocardial infarction (MI). These secrete several proteases, one of them being neutrophil elastase (NE), which promotes inflammatory responses in disease models. It has been shown that there is increase NE activity patients with MI; however, role MI remains unclear. Therefore, present study aimed to investigate pathogenesis mice. expression peaked on day 1 infarcted hearts. In addition, deficiency improved survival and...
Genetic factors may have a significant influence on the likelihood of liver fibrosis in individuals with nonalcoholic fatty disease (NAFLD). The present study was conducted to explore how single-nucleotide polymorphism (SNP) impacts development those suffering from NAFLD. Utilizing UK Biobank dataset, we nested case-control analysis among NAFLD participants, defining case group as and cirrhosis during follow-up. For our vitro investigations, employed LX-2 human hepatic stellate cell line....
Exercise can improve morbidity and mortality in heart failure patients; however, the underlying mechanisms remain to be fully investigated. Thus, we investigated effects of exercise on cardiac function ventricular arrhythmias myocardial infarction (MI) induced mice. Wild-type male mice underwent sham-operation or permanent left coronary artery ligation induce MI. MI were divided into a sedentary (MI-Sed) two intervention groups: MI-Ex (underwent 6-week treadmill training) MI-βb (oral...
Aging and obesity are the most prominent risk factors for onset of atrial fibrillation (AF). Nicotinamide phosphoribosyltransferase (Nampt) is rate-limiting enzyme that catalyzes nicotinamide adenine dinucleotide (NAD) activity. Nampt NAD essential maintenance cellular redox homeostasis modulation metabolism, their expression levels decrease with aging obesity. However, a role in AF unknown. The present study aims to test whether there Nampt/NAD axis pathogenesis obesity-induced AF. Male...
Programmed death ligand 2 (PD-L2) is the second of programmed 1 (PD-1) protein. In autoimmune myocarditis, protective roles PD-1 and its first (PD-L1) have been well documented; however, role PD-L2 remains unknown. this study, we report that deficiency exacerbates myocardial inflammation in mice with experimental myocarditis (EAM). EAM was established wild-type (WT) PD-L2-deficient by immunization murine cardiac myosin peptide. We found had more serious inflammatory infiltration heart a...
Abstract Macrophages are fundamental components of inflammation in post‐myocardial infarction (MI) and contribute to adverse cardiac remodelling heart failure. However, the regulatory mechanisms macrophage activation have not been fully elucidated. Previous studies showed that myeloid‐associated immunoglobulin–like receptor II (MAIR‐II) is involved inflammatory responses macrophages. its role MI unknown. Thus, this study aimed determine a novel mechanism MAIR‐II MI. We first identified...
Oxidative stress could be a possible mechanism and therapeutic target of atrial fibrillation (AF). However, the effects xanthine oxidase (XO) inhibition for AF remain to fully elucidated. We investigated novel XO inhibitor febuxostat on compared with allopurinol in hypertension rat model. Five-week-old Dahl salt-sensitive rats were fed either low-salt (LS) (0.3% NaCl) or high-salt (HS) (8% diet. After 4 weeks diet, HS diet divided into three groups: orally administered vehicle (HS-C), (5...
Granular cell tumor is an infrequent, predominantly benign originating from Schwann cells. of the breast (GCTB) can simulate malignant carcinoma on clinical assessment. We herein present a rare case GCTB which recurred in contralateral breast. believe contrast-enhanced ultrasound (CEUS) findings have never been described. The high similarity makes its differential diagnosis difficult and radiological features. In this report, we CEUS GCTB, explore possible value between lesions ones, briefly...
Objective: To explore the application of new chest holder in median sternotomy for open heart surgery adults. Methods: Two hundred adult patients Henan Provincial People's Hospital from May 2013 to 2015 were enrolled study and randomly divided into two groups. Experimental group included 100 cases who accepted type surgery. Control also composed whose sternums fixed with pure steel wire cerclage. Sternal closure time was recorded since sternum closing. All subjects followed up obtain...
Objective The aim of this study was to evaluate and compare the surgical outcomes endoscop ic conventional open thyroidectomies in patients with thyroid disease.Methods 116 tyroid tumor were enrolled.56 underwent endoscopic thyroidectomy ( group ),and 60 thyroidectomy( group).We analyzed patients' clinic characteristics,surgical complications between two groups.Results blood loss less than group[( 16.8 ± 9.6) ml vs 24.9 14.2 ) ml,t =- 2.427,P ＜ 0.05].The degree satisfaction for cosmetic...