A5054416474- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Smart Grid Energy Management
- Microgrid Control and Optimization
- Integrated Energy Systems Optimization
- CAR-T cell therapy research
- Electric Power System Optimization
- Electric Vehicles and Infrastructure
- Energy Load and Power Forecasting
- Viral Infections and Outbreaks Research
- Cancer Immunotherapy and Biomarkers
- Hybrid Renewable Energy Systems
- RNA Interference and Gene Delivery
- Power Systems and Renewable Energy
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Smart Grid and Power Systems
- Frequency Control in Power Systems
- Glycosylation and Glycoproteins Research
- Poxvirus research and outbreaks
- E-commerce and Technology Innovations
- Wind Turbine Control Systems
Xinjiang University
2017-2025
Tsinghua University
2022-2024
University of Tsukuba
2023
East China University of Science and Technology
2022
Technical University of Applied Sciences Lübeck
2022
Institute of Biophysics
2010-2021
Chinese Academy of Sciences
2007-2021
Beijing Institute of Technology
2020
Dongguk University
2018-2019
Liaoning Normal University
2014
Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy. However, potentially lethal toxicity associated with systemic administration IL-12 precludes its clinical application. Here we redesign molecule in such a way that efficacy is not compromised, but toxic effects are eliminated. Deletion N-terminal signal peptide can effect change by preventing secretion from cells. We use newly designed tumor-targeted oncolytic adenovirus (Ad-TD) to deliver...
Tumor resistance is a major hurdle to anti-Her2/neu Ab-based cancer therapy. Current strategies overcome tumor focus on cell-intrinsic resistance. However, the extrinsic mechanisms, especially microenvironment, also play important roles in modulating therapeutic response and of Ab. In this study, we demonstrate that progression highly associated with TAMs immune-suppressive M2 phenotypes, deletion markedly enhanced effects Ab HER2/neu-dependent breast cell TUBO model. local delivery IL-21...
This study establishes that the experience of narrative transportation has a positive influence on viral advertising. The relative strength this relationship, however, depends several boundary conditions associated with paratextual features social networking service (SNS) environments. Specifically, it is stronger if senders and intended receivers have personal ties. Moreover, negatively moderated by advertising disclosure elicits persuasion knowledge. Finally, negative effect knowledge...
Oncolytic adenoviruses (Ad) represent an innovative approach to cancer therapy. Its efficacy depends on multiple actions, including direct tumor lysis and stimulation of antiviral antitumor immune responses. In this study, we investigated the roles T-cell responses in oncolytic adenoviral therapy.An immunocompetent viral replication-permissive Syrian hamster model was used. The therapeutic mechanisms Ad were by deletion, immunohistochemical staining, CTL assay.Deletion T cells with anti-CD3...
Purpose This paper aims to examine when and how the number of “likes” can exert significant influence on consumer evaluations social media advertising. It sheds a novel perspective “likes”, advertising disclosures presence firm-serving motives effectiveness. Design/methodology/approach Study 1 examines influences attitudes towards sponsoring brand by strengthening credibility, ads are effectively (vs non-effectively) disclosed. 2 further establishes for disclosed varies depending whether...
The efficacy of oncolytic viruses depends on multiple actions including direct tumor lysis, modulation perfusion, and stimulation tumor-directed immune responses. In this study, we investigated whether a sequential combination immunologically distinct might enhance antitumor through the induction tumor-specific immunity circumvention or mitigation antiviral responses.The Syrian hamster as an immune-competent model that supports replication both adenovirus vaccinia virus was evaluated in...
Vaccinia virus has strong potential as a novel therapeutic agent for treatment of pancreatic cancer. We investigated whether arming vaccinia with interleukin-10 (IL10) could enhance the antitumor efficacy view that IL10 might dampen host immunity to virus, increasing viral persistence, thus maximizing oncolytic effect and associated virus.The IL10-armed (VVLΔTK-IL10) control VVΔTK was assessed in cancer cell lines, mice bearing subcutaneous tumors transgenic mouse model. Viral persistence...
Abstract Chronic hepatitis B virus (HBV) infection is characterized by sustained liver inflammation with an influx of lymphocytes, which contributes to the development cirrhosis and hepatocellular carcinoma. The mechanisms underlying this immune-mediated hepatic pathogenesis remain ill defined. We report in article that repetitive infusion anti-CD137 agonist mAb HBV-transgenic mice closely mimics process sequentially inducing hepatitis, fibrosis, cirrhosis, and, ultimately, cancer. CD137...
Agonist antibodies against CD137 (4-1BB) on T lymphocytes are used to increase host anti-tumor immunity, but often leading severe liver injury in treated mice or patients during clinical trials. Interleukin-6 (IL-6) has been reported protect hepatocyte death, the role of IL-6 protecting chronic cell-induced diseases is not clearly defined due lack relevant animal models. We aimed define CD8+ cell-mediated induced by a agonistic mAb (clone 2A) mice.We expressed hydrodynamic gene delivery with...
This paper propose a Nash Stackelberg game based trading decision model of joint power market contain frequency/regulation/reserve for day ahead transaction to deal with the challenges brought by insufficient peak shaving and frequency regulation capacity high proportion renewable energy. utilizes Copula-CVaR quantify risk revenue loss caused uncertainty generation consumption. The double layer considering total cost profits multiple types independent operating entities. So proposed is...
To improve the utilization of flexible resources in microgrids and meet energy storage requirements different scenarios, a centralized shared capacity optimization configuration model for based on bi-level is proposed. First, response characteristics controllable load resilience microgrid are analyzed, operation mode meeting regulatory demand multi-scenarios designed. Then, optimal allocation constructed, which takes maximum net income as upper layer minimum payment cost lower layer....