A5019195475- Magnetic Properties and Applications
- Immune Cell Function and Interaction
- Microstructure and Mechanical Properties of Steels
- Magnetic properties of thin films
- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- Flavonoids in Medical Research
- Magnetic Properties of Alloys
- CAR-T cell therapy research
- Advanced Breast Cancer Therapies
- Iron-based superconductors research
- Spectroscopy and Laser Applications
- Cancer Treatment and Pharmacology
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Terahertz technology and applications
- Natural product bioactivities and synthesis
- Hematopoietic Stem Cell Transplantation
- Molecular Spectroscopy and Structure
- Metallurgical and Alloy Processes
- Shape Memory Alloy Transformations
Henan Institute of Science and Technology
2025
Institute of Molecular and Cell Biology
2016-2021
Agency for Science, Technology and Research
2017-2020
Nanyang Technological University
2019-2020
Epigénétique et Destin Cellulaire
2019
Institute for Stem Cell Biology and Regenerative Medicine
2019
Beckman Research Institute
2009-2017
City of Hope
2009-2017
Ames National Laboratory
2008-2016
Beijing Institute of Technology
2015-2016
A rare-earth supply crisis has stimulated an intensive search for alternative permanent magnets. Alnico materials, alloys containing Al, Ni, Co and Fe, are functional nanostructured alloys, which show great potential replacing the best commercial Nd-based applications above 200 °C. However, their coercivity is ∼2–3× below theoretical limits. The of alnico depends on nanostructure developed during spinodal decomposition. In this work, atom probe tomography, combined with advanced electron...
To assess the relation of Foxp3(+) regulatory T cells (Treg) in tumor draining lymph nodes (TDLNs) with progression and immune suppression colorectal cancer (CRC).Flow cytometry was used to analyze densities Tregs lymphocytes TDLNs, peripheral blood, tumors from 34 patients CRC. The frequency compared evaluated for association disease stage. effect on function CD8(+) investigated by IFN-gamma production.The density TDLNs dramatically higher than that blood lymphocytes, but significantly...
The blockade of PD-1–PD-L1 pathway is emerging as an effective therapeutic strategy for several advanced cancers. But the immune regulatory role not clear in colorectal cancer (CRC) patients. This study aims to evaluate CD8+ T-cell functions tumour-draining lymph nodes (TDLNs) and tumours CRC PD-1 expression on T cells was examined by flow cytometry, PD-L1 TDLNs tumour tissues were immunohistochemistry. Production IFN-γ, IL-2 granzyme B, perforin detected intracellular staining. markedly...
Joint profiling of transcriptome and chromatin accessibility within single cells allows for the deconstruction complex relationship between transcriptional states upstream regulatory programs determining different cell fates. Here, we developed an automated method with high sensitivity, assay single-cell regions (ASTAR-seq), simultaneous measurement whole-cell same cell. To show utility ASTAR-seq, profiled 384 mESCs under naive primed pluripotent as well a two-cell like state, 424 human...
H3.3 is a histone variant, which deposited on genebodies and regulatory elements, by Hira, marking active transcription. Moreover, heterochromatin Atrx/Daxx complex. The exact role of in cell fate transition remains elusive. Here, we investigate the dynamic changes deposition variant during cellular reprogramming. maintains identities parental cells reprogramming as its removal at early time-point enhances efficiency process. We find that plays similar transdifferentiation to hematopoietic...
We study the relationship between precipitate morphology and superconductivity in KxFe1.6+ySe2 single crystals grown by self-flux method. Scanning electron microscopy (SEM) measurements revealed that superconducting phase forms a network samples quenched above iron vacancy order-disorder transition temperature Ts. For obtained natural cooling down to room furnace, referred as furnace cooling, aggregates into micrometer-sized rectangular bars aligns disconnected chains. Accompanying this...
Integrative single-cell analysis de-constructs the heterogeneity of human reprogramming and uncovers its stage-specific GRNs.
Agonist antibodies against CD137 (4-1BB) on T lymphocytes are used to increase host anti-tumor immunity, but often leading severe liver injury in treated mice or patients during clinical trials. Interleukin-6 (IL-6) has been reported protect hepatocyte death, the role of IL-6 protecting chronic cell-induced diseases is not clearly defined due lack relevant animal models. We aimed define CD8+ cell-mediated induced by a agonistic mAb (clone 2A) mice.We expressed hydrodynamic gene delivery with...
Insight into microstructural features in commercial alnico alloys is revealed through electron microscopy. Significant differences were found the chemical make-up of primary phases and their distributions for different classes alloys. Changes Co + Fe : Al Ni minor alloying elements shift matrix phase from an ordered B2 5-7 to a L2 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> 8 9. The question whether FeCo-rich has or body-centered...
Magnetic and structural transitions in the Ni50Mn50−xSnx (x=10–25) ferromagnetic shape memory alloys are currently of interest. As Ni–Mn–Ga, these feature high-temperature austenite low-temperature martensite phases, where magnetic state is strongly composition dependent. To study role chemical ordering fine-tuning their magnetostructural properties, they were first annealed for 4 weeks/1223 K to achieve compositional homogeneity, then further 1 week (∼150 below reported B2 L21 transition)...
Lorentz microscopy was applied to the observation of magnetic domains in iron-gallium (Fe–Ga) alloys. Results did not show any link between and magnetostriction enhancement by Ga addition, but reveal that drastic decrease for Fe–31.2 at. % due presence large scale precipitates. Magnetic domain features change alloys A2, D03, A2+D03, A2+B2+D03, A2+fine Large precipitates within slow-cooled affected both distribution wall motion domains.
The addition of nonmagnetic Ga into body-centered cubic Fe enhances the magnetostriction constant λ100 over tenfold. Literature reports for substitution Ge at low concentrations suggest that also magnetostriction. In this work, and microstructure Fe–Ge were investigated to correlate with microstructure. Fe100−xGex single crystals x between 0.05 0.18 varies concentration correlates phase changes. value (3∕2)λ100 increases additions in A2 region (up x∼10), reaching a maximum 94ppm solubility...
We fabricated a NOA81 PCR chip (NP-chip) and first proposed simple BSA coating method to successfully overcome the low efficiency induced by inhibition of NP-chip which seriously impacted its application in area gene amplification.