A5034534226- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- IL-33, ST2, and ILC Pathways
- Seaweed-derived Bioactive Compounds
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Helicobacter pylori-related gastroenterology studies
- Pregnancy and preeclampsia studies
- Genetic and Kidney Cyst Diseases
- Natural product bioactivities and synthesis
- Inflammatory Bowel Disease
- Rheumatoid Arthritis Research and Therapies
- Hippo pathway signaling and YAP/TAZ
- Birth, Development, and Health
- Cancer-related Molecular Pathways
- Sleep and Wakefulness Research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Whipple's Disease and Interleukins
Shandong University
2015-2024
Hebei Medical University
2019-2024
Xingtai People's Hospital
2019-2024
Shandong Provincial Hospital
2021-2024
Linyi People's Hospital
2015-2021
Linyi University
2015
Institute of Biophysics
2010
Chinese Academy of Sciences
2010
Chinese Academy of Medical Sciences & Peking Union Medical College
2010
To assess the relation of Foxp3(+) regulatory T cells (Treg) in tumor draining lymph nodes (TDLNs) with progression and immune suppression colorectal cancer (CRC).Flow cytometry was used to analyze densities Tregs lymphocytes TDLNs, peripheral blood, tumors from 34 patients CRC. The frequency compared evaluated for association disease stage. effect on function CD8(+) investigated by IFN-gamma production.The density TDLNs dramatically higher than that blood lymphocytes, but significantly...
Abstract Gastric cancer is one of the most lethal human malignancies in world. Although great efforts are put developing novel therapeutic targets, effective targeting drugs still limited. Recent studies reveal abnormality Hippo/YAP axis play critical role oncogenic process gastric cancer. It importance to demonstrate regulation Hippo signaling activity and YAP protein turnover Besides, phosphorylation cascade on function, which has been thoroughly investigated, ubiquitination also important...
Long noncoding RNA (lnc ) DLEU 2 has been shown to be dysregulated in several type of tumor. However, the potential biological roles and molecular mechanisms pancreatic cancer ( PC progression are poorly understood. In this study, we found that level was substantially upregulated tissues cell lines, significantly associated with poor clinical outcomes patients. Overexpression induced proliferation invasion, whereas knockdown impaired invasion vitro. Furthermore, bioinformatics analysis,...
miR-522-3p is known to degrade bloom syndrome protein (BLM) and enhance expression of other proto-oncogenes, leading tumorigenesis. This study aimed investigate the molecular mechanisms in human colorectal cancer (CRC) cells. Expressions CRC adjacent tissues, as well normal colon epithelial cell line (FHC) five lines, were detected. Human HCT-116 HT29, transfected with mimic, inhibitor, or scrambled controls. Then viability, apoptosis, cycle progression, expressions c-myc, cyclin E, CDK2,...
Among all of the miRNAs, miR-204 has gained considerable attention in field cancer research. This study aimed to reveal detailed functions and underlying mechanism colorectal (CRC) cells. The expressions CRC tumor tissues cell lines were monitored. Expressions CXCL8 Caco-2 HT-29 cells altered by transfection, then viability, apoptosis, migration, invasion, EMT-related protein expression, PI3K/AKT/mTOR pathway expression assessed. We found that was expressed at low levels when compared their...
Chemotherapy resistance poses a major challenge for the clinical treatment of colorectal cancer, therefore, aim present study was to examine its underlying mechanisms. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used determine microRNA (miRNA)/mRNA protein expression levels, respectively. A dual luciferase assay conducted verification interaction between miR‑106a 3'untranslated region (UTR) Forkhead box Q1 (FOXQ1). Cell viability assessed using...
Background: Crohn's disease (CD) and rheumatoid arthritis (RA) are immune-mediated inflammatory diseases. However, the molecular mechanisms linking these two diseases remain unclear. Methods: To identify shared core genes between CD RA, we employed differential gene analysis least absolute shrinkage selection operator (LASSO) algorithm. Functional annotation of biomarkers was performed using consensus clustering set enrichment analysis. We also constructed a protein-protein network...
// Zhulei Sun 1, * , Juncai Liu 2, Hong Jing 1 Shu-Xiao Dong 3 and Jiang Wu Department of Pathology, Huaihe Hospital, Henan University, 8 Bao Bei Lu, GuLou Qu, Kaifeng 475000, China 2 Radiotherapy, Gastrointestinal Surgery, Linyi People's 276001, Shandong, These authors contributed equally to this work Correspondence to: Wu, email: jiangwumi@hotmail.com Keywords: CHFR, methylation, biomarker, CRC, colorectal carcinoma Received: March 13, 2017 Accepted: June 24, Published: July 20, ABSTRACT...
The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility gastric cancer. Samples from a total 202 cancer patients and 237 controls were collected Linyi People's Hospital between March 2013 2015. IL-17 gene polymorphism identified by polymerase chain reaction restriction fragment length polymorphism. When compared with control subjects, older in age (OR = 3.89, 95%CI 2.55-5.95), male 2.08,...
Chemotherapy is widely used in a variety of solid tumors, such as lung cancer, gastric cancer and breast cancer. The genotoxic drugs, cisplatin, suppress progression either by inhibition cell proliferation or facilitating apoptosis. However, the chemotherapy resistance remains an urgent challenge therapy, especially advanced stages. Several studies showed that activation pro-survival pathways, PI3K-AKT, participated mediating resistance. insights into molecular mechanisms for underlying are...
Background: Kinesin Family Member 3B (KIF3B) is one of the most ubiquitously expressed KIFs, which related to numerous physiological responses. KIF3B has also been implicated in carcinogenesis such as hepatocellular carcinoma cells. However, expression not studied pancreatic cancer along with its clinical significance. Methods: Immunohistochemical assays were performed detect levels tumor tissues and adjacent non-tumor tissues. Patients sequentially divided into different group based on...
Preeclampsia and eclampsia are severe pregnancy disorders marked by hypertension potential organ damage. The etiological basis of preeclampsia is not fully understood. Previous studies have revealed a link between sleep abnormality preeclampsia/eclampsia, but the causal relationship remains unclear. In this study, we explored genetic links preeclampsia/eclampsia using genome-wide association study (GWAS) summary data Mendelian randomization (MR) analysis.
Male breast cancer is a rare studied of disease and the relevant research also very scarce. Current treatment male modeled after female cancer, namely surgery-based comprehensive treatment, which for men to bear trauma psychological blow. In this study, we explored efficacy hapten enhanced intratumoral chemotherapy treating cancer. We used scRNA-Seq profile changes induced by chemotherapy. demonstrate that Hapten-enhanced (HEIC) induces an acute immune response, in turn helps kill control...