A5066886328- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Mobile Ad Hoc Networks
- Opportunistic and Delay-Tolerant Networks
- Cooperative Communication and Network Coding
- Optical measurement and interference techniques
- Image Processing Techniques and Applications
- Medical Image Segmentation Techniques
- Advanced X-ray and CT Imaging
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Functional Brain Connectivity Studies
- Advanced Vision and Imaging
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Distributed systems and fault tolerance
- Optical Imaging and Spectroscopy Techniques
- Distributed and Parallel Computing Systems
- Crystallography and molecular interactions
- Parkinson's Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Acupuncture Treatment Research Studies
- Cell Image Analysis Techniques
- Optimization and Search Problems
- Pharmacological Receptor Mechanisms and Effects
Washington University in St. Louis
2020-2024
Second Hospital of Shandong University
2022-2024
University of Tennessee Health Science Center
2024
Third Affiliated Hospital of Zhengzhou University
2024
Wuhan Ship Development & Design Institute
2024
Anhui Xinhua University
2024
Beijing Union University
2023
Shandong University
2022
Xinxiang Medical University
2022
Southeast Missouri State University
2004-2022
Abstract Gastric cancer is one of the most lethal human malignancies in world. Although great efforts are put developing novel therapeutic targets, effective targeting drugs still limited. Recent studies reveal abnormality Hippo/YAP axis play critical role oncogenic process gastric cancer. It importance to demonstrate regulation Hippo signaling activity and YAP protein turnover Besides, phosphorylation cascade on function, which has been thoroughly investigated, ubiquitination also important...
This paper proposes a novel method to substantially reduce motion-introduced phase error in phase-shifting profilometry. We first estimate the motion of an object from difference between two subsequent 3D frames. After that, by leveraging projector's pinhole model, we can determine motion-induced shift estimated motion. A generic algorithm considering is then utilized compute phase. Experiments demonstrated that proposed effectively improved measurement quality compensating for introduced...
We propose a hybrid computational framework to reduce motion-induced measurement error by combining the Fourier transform profilometry (FTP) and phase-shifting (PSP). The proposed method is composed of three major steps: Step 1 extract continuous relative phase maps for each isolated object with single-shot FTP spatial unwrapping; 2 obtain an absolute map entire scene using PSP method, albeit errors exist on extracted map; 3 shift from generate final referring 2. Experiments demonstrate...
We had successfully applied the near-infrared CuInS<sub>2</sub> QDs-based fluorescence acid phosphatases probe to perform <italic>in vitro</italic> imaging of human prostate cancer cells.
Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few examined clinical pain. In the current study, we combined an experimental acute low back pain (ALBP) model and functional magnetic resonance imaging (fMRI) to explore neural mechanisms of analgesia. All ALBP subjects first underwent two resting state fMRI scans at baseline during painful episode then additional scans, once stimulation (ACUP)...
Abstract Post stroke depression (PSD) is a serious complication of stroke. Brain imaging an important method studying the mechanism PSD. However, few studies have focused on single lesion location. The aim this study was to investigate brain frontal lobe PSD using combined voxel-based morphometry (VBM) and functional magnetic resonance (fMRI). In total, 30 first-time ischemic patients underwent T1 weighted MRI resting-state fMRI scans. Clinical assessments included 24-item Hamilton Rating...
The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis commonly observed gastric cancer, while effective therapeutic targets for are lacking. Identification reliable drug underlying mechanisms that could inhibit activity cancer progression urgently needed.We used several cell lines xenograft models performed immunoblotting, qPCR, vivo studies to investigate function CXCR7 progression.In our current study, we demonstrate membrane receptor...
Abstract Background Functional imaging studies have indicated that patients with low back pain can significant reductions in cerebral cortex grey matter. However, the mechanisms governing nociceptive pathways human brain are unclear. The aim of this study was to use functional magnetic resonance (fMRI) and regional homogeneity (ReHo) investigate changes resting-state activity subjects experienced experimentally induced pain. Methods Healthy (n = 15) underwent fMRI (3.0 T) at baseline during...
A new anticancer drug delivery system was developed based on the electrostatic complex of positively charged CuInS2 quantum dots (QDs) and negatively poly(l-glutamic acid) (PGA) conjugated with model doxorubicin (DOX). Water-soluble near-infrared QDs capped l-cysteine were directly synthesized by a hydrothermal method. DOX can quench photoluminescence in QDs/PGA-DOX nanoparticles through photoinduced electron transfer process, thus are fluorescence "turn-off" state. After exposed to...
Functional magnetic resonance imaging studies have shown that the insular cortex has a significant role in pain identification and information integration, while default mode network is associated with cognitive memory-related aspects of perception. However, changes functional connectivity between insula during remain unclear. This study used 3.0 T scans 12 healthy subjects aged 24.8 ± 3.3 years to compare differences activity baseline condition induced by intramuscular injection hypertonic...
Reliable performance of PET segmentation algorithms on clinically relevant tasks is required for their clinical translation. However, these are typically evaluated using figures merit (FoMs) that not explicitly designed to correlate with task performance. Such FoMs include the Dice similarity coefficient (DSC), Jaccard (JSC), and Hausdorff distance (HD). The objective this study was investigate whether evaluating task-agnostic yields interpretations consistent evaluation quantitative tasks.
Abstract Background The Hippo pathway functions as a tumor suppressor in human cancers, while dysfunction of the is frequently observed malignancies. Although YAP/TAZ activity tightly controlled by phosphorylation cascade MST-LATS-YAP/TAZ axis, it still unclear why proteins are activated cancers despite activation. Recent studies have suggested that addition to phosphorylation, several other posttranslational modifications, including ubiquitination, also play critical roles modulating TAZ...
Abstract Background Ubiquitous mitochondrial creatine kinase (uMtCK) transfers high-energy phosphates from mitochondrially generated ATP to generate phosphocreatine. uMtCK overexpression has been reported in several malignant tumors, however, the clinical significance and impact of gastric cancer (GC) not comprehensively studied. Methods We first examined expression GC by quantitative real-time PCR western blot assays. Then clinicopathological aberrant was determined immunohistochemical...
Research on the mechanism of post stroke depression (PSD) is key way to improve treatment PSD. However, functional brain network PSD has not been entirely supported by results magnetic resonance imaging (fMRI) studies. The aims this study are investigate response in three different lesions. responses subgroups were similar. each subgroup had its own characteristics network. In temporal lobe subgroup, right thalamus increased degree centrality (DC) values which from other two subgroups....
Abstract Tumor segmentation in oncological PET is challenging, a major reason being the partial-volume effects (PVEs) that arise due to low system resolution and finite voxel size. The latter results tissue-fraction (TFEs), i.e. voxels contain mixture of tissue classes. Conventional methods are typically designed assign each image as belonging certain class. Thus, these inherently limited modeling TFEs. To address challenge accounting for PVEs, particular, TFEs, we propose Bayesian approach...
Although high serum cholesterol is widely recognized as a major risk factor for heart disease, the health effects of low are less clear. Several studies have found correlation between and depression, but results inconsistent.Data from National Health Nutrition Examination Survey (NHANES) 2005-2018 were utilized in this cross-sectional study. The analysis relationship depression was performed at three levels: total cholesterol, high-density lipoprotein (HDL) low-density (LDL) cholesterol....
Ovarian cancer is the most lethal gynecological malignancy, with a 5-year survival rate of approximately 50%. The dismal prognosis due in part to metastatic disease and acquired drug resistance conventional chemotherapies such as taxanes. Colchicine binding site inhibitors (CBSIs) are attractive alternatives taxanes because they could potentially achieve oral bioavailability overcome associated prolonged use VERU-111 one advanced CBSIs that orally available, potent, well tolerated has shown...