A5005557287- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- PARP inhibition in cancer therapy
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Dermatologic Treatments and Research
- Cancer Cells and Metastasis
- Body Contouring and Surgery
- PI3K/AKT/mTOR signaling in cancer
- Osteoarthritis Treatment and Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Anorectal Disease Treatments and Outcomes
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
Shanghai Sixth People's Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
University of Electronic Science and Technology of China
2023-2024
Sun Yat-sen University
2023
Chongqing University
2023
Shenyang University of Technology
2023
Xuzhou University of Technology
2023
Sichuan University
2020-2022
West China Hospital of Sichuan University
2020-2022
Xuzhou Medical College
2022
Articular cartilage injury is a prevalent clinical condition resulting from trauma, tumors, infection, osteoarthritis, and other factors. The intrinsic lack of blood vessels, nerves, lymphatic vessels within tissue severely limits its self-regenerative capacity after injury. Current treatment options, such as conservative drug therapy joint replacement, have inherent limitations. Achieving perfect regeneration repair articular remains an ongoing challenge in the field regenerative medicine....
TCF12, which is known to be involved in the regulation of cell growth and differentiation, has been reported function as an oncogene or a tumor suppressor gene progression various malignant tumors. However, its molecular mechanism hepatocellular carcinoma (HCC) remain unclear. Methods: Stable ectopic TCF12 expression knockdown HCC lines was established by lentiviral infection. Then, MTT, colony formation, migration, invasion HUVECs tube formation assays well orthotopic xenograft model were...
AKR1C3 is an enzyme belonging to the aldo-ketoreductase family, members of which catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. plays important role tumor progression metastasis, however, little known about function molecular mechanism underlying hepatocellular carcinoma (HCC). In this study, we report that significantly upregulated HCC increased associated with poor survival. positively regulated cell proliferation metastasis
Abstract Cancer-associated fibroblasts (CAF) constitute a major component of the tumor microenvironment. The effects CAFs on progression colorectal cancer remain controversial. In this study, we found ectopic overexpression Fibronectin leucine-rich transmembrane protein 3 (FLRT3) inhibited process epithelial–mesenchymal transition (EMT), as well proliferation, migration, invasion, and promote apoptosis cells, whereas silencing FLRT3 expression resulted in opposite phenomenon. downregulation...
Abstract Background Metabolic syndrome (MetS) is characterized by a cluster of signs metabolic disturbance and has caused huge burden on the health system. The study aims to explore prevalence characteristics MetS defined different criteria in Chinese population. Methods Using data China Hypertension Survey (CHS), nationally representative cross-sectional from October 2012 December 2015, total 28,717 participants aged 35 years above were included analysis. definitions International Diabetes...
The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe new CRC tumor suppressor potential therapeutic target: thymocyte selection associated high mobility group box (TOX) protein. expression TOX was lower in than para-CRC. With the increase stage, decreased, indicating presence relates to better overall survival (OS). suppressed mechanistic target rapamycin kinase (mTOR) signaling inhibit cell proliferation, migration,...
Long noncoding RNA (lncRNA) plays a crucial role in the pathogenesis of various diseases, including colorectal cancer (CRC). The gene mutations adenomatous polyposis coli (APC) were found most patients with CRC. They function as important inducers tumorigenesis. Based on our microarray results, we identified specific upregulated lncRNA CRC (SURC). Further analysis showed that high SURC expression correlated poorer disease-free survival and overall Furthermore, mutated APC genes can promote...
To investigate the abundance and potential functions of LAP+CD4+ T cells in colorectal cancer (CRC).Proportions were examined peripheral blood tumor/paratumor tissues CRC patients healthy controls using flow cytometry. Expression phenotypic markers such as forkhead box (Fox)p3, cytotoxic T-lymphocyte-associated protein (CTLA)-4, chemokine CC receptor (CCR)4 CCR5 was measured LAP-CD4+ isolated a magnetic cell-sorting system cell purity analyzed by Real-time quantitative polymerase chain...
Recently, endoplasmic reticulum (ER) stress has been shown to influence tumor progression and immune cell function in the microenvironment (TME). However, underlying role of ER stress-related gene patterns colorectal cancer (CRC) development remains unclear. We analyzed 884 patients with CRC from Gene Expression Omnibus database evaluated cell-infiltrating TME. Two were identified that had distinct TME clinical characteristics. A risk score nomogram based on 14 screened prognosis-correlated...
Colorectal cancer (CRC)-associated senescent fibroblasts may play a crucial role in tumor progression, but the mechanism remains unclear. In order to solve this complicated problem, we randomly collected sixteen patients with CRC, who had been treated oxaliplatin and capecitabine (XELOX). Hematoxylin-eosin (HE) staining revealed that Tumor-stroma ratio (TSR) of CRC was affected by XELOX treatment. Immunohistochemistry (IHC) senescence‐associated β‐galactosidase (SAβG) were used verify stable...
Malignant transformation of gastrointestinal stromal tumors (GISTs) is correlated with poor prognosis; however, the underlying biological mechanism not well understood. In present study, low-risk (LR) GISTs, GISTs categorized as high-risk based on tumor size (HBS), and mitotic rate (HBM) were collected for RNA sequencing. Candidate hub lncRNAs selected by Oncomine analysis. Expression a lncRNA, DNM3OS, its correlation patients' prognosis analyzed using FISH staining, followed determination...