A5101905624- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Chronic Myeloid Leukemia Treatments
- Histone Deacetylase Inhibitors Research
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- RNA Research and Splicing
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Retinoids in leukemia and cellular processes
- Per- and polyfluoroalkyl substances research
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- Circular RNAs in diseases
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Renal and related cancers
- Cancer-related molecular mechanisms research
Capital Medical University
2017-2025
Nanchong Central Hospital
2025
Beijing Anzhen Hospital
2025
Hebei Academy of Agriculture and Forestry Sciences
2024
Bengbu Medical College
2024
Dalian University of Technology
2022
Nankai University
2018-2021
Huazhong University of Science and Technology
2021
Tangshan People's Hospital
2021
State Key Laboratory of Oncogene and Related Genes
2018-2019
Somatic mutations of DNMT3A gene have recently been reported in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We examined the entire coding sequences by high-resolution melting analysis sequencing Chinese patients with malignancies. R882 were found 12/182 AML 4/51 MDS, but not either 79 chronic (CML), or 57 myeloproliferative neoplasms (MPNs), 4 monomyelocytic leukemia. No other detected all patients. associated old age more frequently present monoblastic (M4 M5, 7/52)...
The renal and hepatic clearance rates of organophosphate esters (OPEs) in humans were estimated. Six OPEs their corresponding diester metabolites (mOPEs) quantified respectively 30 paired human plasma urine samples collected Hengshui, Hebei province, China. rate (CLrenal) triphenyl phosphate (TPHP), tris(chloroethyl) (TCEP) tris(1,3-dichloro-isopropyl) (TDCIPP) was estimated to be 68.9, 50.9 33.3 mL/kg/day, respectively, while it not calculated for other three due the low detection...
TCF12, which is known to be involved in the regulation of cell growth and differentiation, has been reported function as an oncogene or a tumor suppressor gene progression various malignant tumors. However, its molecular mechanism hepatocellular carcinoma (HCC) remain unclear. Methods: Stable ectopic TCF12 expression knockdown HCC lines was established by lentiviral infection. Then, MTT, colony formation, migration, invasion HUVECs tube formation assays well orthotopic xenograft model were...
Abstract The polycyclic aromatic hydrocarbon (PAH) concentrations in total suspended particulate matter (TSP) samples collected from October, 2021 to September, 2022 were analyzed clarify the pollution characteristics and sources of 16 PAHs atmospheric TSP Bengbu City. ρ(PAHs) ranged 1.71 43.85 ng/m 3 higher detected winter, followed by spring, autumn, summer. positive matrix factorization analysis revealed that, spring summer, PAH was caused mainly industrial emissions, gasoline diesel fuel...
Somatic mutations of U2AF1 gene have recently been identified in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this study, we analyzed the frequency clinical impact a cohort 452 Chinese patients with neoplasms. Mutations were found 2.5% (7/275) AML 6.3% (6/96) MDS patients, but none 81 CML. All heterozygous missense affecting codon S34 or Q157. There was no significant association mutation blood parameters, FAB subtypes, karyotypes other AML. The overall survival (OS)...
Objective Disulfidptosis is a newly identified type of nonapoptotic programmed cell death related to mechanisms such as ferroptosis, cuproptosis, pyroptosis, and necrotic apoptosis. This study explores the role disulfidptosis-related long non-coding RNAs (DRLs) in gastric cancer their potential prognostic biomarkers. Method We developed model using DRL scores classify patients based on disulfidptosis activity. evaluated these for correlations with drug sensitivity, tumor microenvironment...
Objective To investigate the changes in serum growth hormone (GH), testosterone, and insulin-like factor 1 (IGF-1) during low-intensity resistance exercise under different cuff pressures. Methods We performed a single-blind, cross-over design study. Twenty-five healthy young men three protocols as follows: 1) no blood flow restriction (control group), 2) at 40% of arterial occlusion pressure (AOP) (low 3) 70% AOP (high group). Blood lactate, GH, IGF-1 levels were measured four time points....
The surgical extension of lateral neck dissection (LND) in papillary thyroid carcinoma (PTC) with clinical lymph node metastases (LLNM) remains controversial. aim this study was to explore the pattern and clinicopathologic risk factors for LLNM PTC unilateral LND determine rational extent therapeutic LND. This retrospective reviewed records 246 consecutive patients who simultaneously underwent total thyroidectomy, bilateral central dissection, frequency were analyzed. Grossly, present 80.9%...
Hotspot mutations of serine/arginine-rich splicing factor 2 (SRSF2) gene have been identified in a proportion hematologic malignancies including myelodysplastic syndrome (MDS). The aim the present study was to develop new approach screen SRSF2 mutation and analyze clinical relevance Chinese MDS. A protocol based on high-resolution melting analysis (HRMA) established SRSF2-P95 108 MDS patients compared with Sanger sequencing. further evaluated. HRMA five (4.6%) cases mutation, completely...
Background Accurate diagnosis of papillary thyroid microcarcinoma (PTMC) is important for further management. Ultrasound (US) the most frequently used imaging modality PTMC. Purpose To evaluate diagnostic value conventional US, contrast-enhanced ultrasound (CEUS) and real-time elastography (RTE) patients with Material Methods In total, 135 subcentimeter nodules who underwent CEUS, RTE before surgery were enrolled. A multivariate logistic regression analysis was performed to assess...
Bisphenol AF (BPAF) and perfluorooctanoic acid (PFOA) may display combined estrogenic effects on aquatic organisms, because BPAF PFOA are widely present in the environment reported to have organisms. In this study, zebrafish embryos were exposed BPAF, PFOA, binary mixtures of both for 7 days using estradiol (E2) vitellogenin (VTG) as biomarkers. The estrogen receptor α (erα) expression VTG level increased upon single exposures (0.0372 0.372 μM) (1.21 12.1 μM). Although them stimulated P450...