A5015150059- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Retinoids in leukemia and cellular processes
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Glycosylation and Glycoproteins Research
- Axon Guidance and Neuronal Signaling
- Circular RNAs in diseases
- Multiple Myeloma Research and Treatments
- Functional Brain Connectivity Studies
- Acute Lymphoblastic Leukemia research
- Heavy Metal Exposure and Toxicity
- EEG and Brain-Computer Interfaces
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medical Research and Treatments
- Kruppel-like factors research
Jiangsu University
2015-2025
Affiliated Hospital of Jiangsu University
2015-2025
Shanghai Clinical Research Center
2018-2025
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Children's Hospital of Los Angeles
2024
University of Southern California
2024
Guangzhou Medical University
2023-2024
Zhanjiang Experimental Station
2018-2022
Nanjing Medical University
2020
The long non-coding RNA H19 plays a crucial role in solid tumor initiation and progression. However, the potential of its clinical significance acute myeloid leukemia (AML) remain largely elusive. expression was detected by qPCR, AML patients further analyzed. Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) data for were used as validation cohorts. roles cell proliferation apoptosis determined assay flow cytometry analysis. significantly increased but not associated with embedded...
Chemoresistance is one of the causes associated with poor prognosis in gastric cancer. MicroRNAs (miRNAs) are important regulators chemoresistance. Exosome-mediated delivery anti-cancer molecules and drugs have emerged as a new approach for cancer therapy. We first examined expression miR-374a-5p serum by qRT-PCR explored clinicopathological parameters. then performed vitro cell molecular studies, including CCK-8 assay, flow cytometry, qRT-PCR, western blot, to determine roles...
BCL2 protein inhibitor venetoclax (ABT-199) has been authorized by Food and Drug Administration for relapsed/refractory chronic lymphoid leukemia with 17p deletion. Although venetoclax/ABT-199 also caused cell death in acute myeloid (AML), whether it could be applied to clinical treatment needs further studies. Here, we revealed implication of overexpression de novo adult AML, may provide theoretical basis targeted therapy using venetoclax. expression was analyzed AML patients from public...
Abstract Promoter hypermethylation‐mediated inactivation of ID4 plays a crucial role in the development solid tumours. This study aimed to investigate methylation and its clinical relevance myeloid malignancies. hypermethylation was associated with higher IPSS scores, but not an independent prognostic biomarker affecting overall survival (OS) myelodysplastic syndrome (MDS). However, correlated shorter OS leukaemia‐free (LFS) time acted as risk factor acute leukaemia (AML). Moreover,...
DNA methyltransferases (DNMTs) by regulating methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified high incidence DNMT3A mutation AML, and it is correlated with poor prognosis. Although a few studies shown expression DNMTs their clinical significance results remain to be discussed. Herein, we systemically analyzed relationship clinic-pathological features prognosis AML patients....
Receptor-interacting protein kinase 3 (RIPK3) has been implicated in the pathogenesis of diverse human cancers. However, role RIPK3 acute myeloid leukemia (AML) is not fully understood, which needs further research and clarification. We first identified expression clinical prognostic value AML through a public database validated our cohort. In addition, biological function leukemic development was verified vitro experiments. Based on GEPIA database, we screened that overexpression among RIPK...
Diffuse large B-cell lymphoma/high-grade lymphoma with MYC and BCL2 rearrangements (DLBCL/HGBL-MYC/BCL2) represents a distinct entity of mature aggressive lymphoma, constituting substantial gap in the clinical management DLBCL. Conventional R-CHOP-like chemoimmunotherapy regimens have demonstrated limited efficacy DLBCL/HGBL-MYC/BCL2, outcome remains poor, median overall survival less than 2 years, even shorter cases transformed from indolent lymphoma. We reported 66-year-old female was...
Abundant studies have shown that lncRNA PANDAR plays an oncogenic role in human solid tumors. Although abnormal expression of has been well investigated tumors, it was rarely studied hematologic diseases. Hence, the aim this study to determine level and its clinical significance patients with acute myeloid leukemia (AML).For detecting 119 AML 26 controls, real-time quantitative PCR used study. The prognostic values were evaluated by using Kaplan-Meier analysis, Cox regression analyses,...
Background: Altered expression of the BCL-2 family member MCL-1 has been linked to progression and outcome various malignancies. Recently, inhibitor S63845 was reported kill MCL-1-dependent cancer cells potential value in clinical application. Purpose: Herein, we pattern Chinese de novo acute myeloid leukemia (AML) its impact on prognosis may provide theoretical basis for AML patients using clinics. Real-time quantitative PCR carried out detect transcript patients. Results:MCL-1...
Abstract The deregulated DLX gene family members DLX1/2/3/4/5/6 ( DLXs ) caused by DNA methylation has been demonstrated in various cancers with therapeutic target value. However, the potential role of myeloid neoplasms such as acute leukemia (AML) and myelodysplastic syndromes (MDS) remains to be elucidated. Clinical significance methylation/expression was analyzed patient AML MDS. functional roles were determined vitro. In identification stage, we found that lower DLX5 expression...
// Jing-Dong Zhou 1, 3, * , Dong-Ming Yao 2, Xi-Xi Li Ting-Juan Zhang 3 Wei Ji-Chun Ma Hong Guo Zhao-Qun Deng Jiang Lin and Jun Qian 1 Department of Hematology, Affiliated People's Hospital Jiangsu University, Zhenjiang, Jiangsu, Republic China 2 Laboratory Center, The Key Precision Diagnosis Treatment Zhenjiang City, These authors have contributed equally to this work Correspondence to: Qian, email: qianjun0007@hotmail.com Lin, linjiangmail@sina.com Keywords: RAS expression, mutation,...
Methylation-associated SOX family genes have been proved to be involved in multiple essential processes during carcinogenesis and act as potential biomarkers for cancer diagnosis, staging, prediction of prognosis, monitoring response therapy. Herein, we revealed SOX30 methylation its clinical implication acute myeloid leukemia (AML) myelodysplastic syndromes (MDS). In the discovery stage, identified that methylation, a frequent event AML, was negatively associated with expression correlated...
ObjectiveAbnormal expression of microRNA-215 has been identified in a variety solid cancers. However, little is known about the pattern acute myeloid leukemia. This study was to investigate status and further analyze its clinical significance
MircoRNA-335 (miR-335) has been reported as a significant cancer-associated microRNA, which was often epigenetically silenced and acted tumor suppressor gene in diverse human solid tumors. Conversely, recent studies show that miR-335 overexpression identified both adult pediatric acute myeloid leukemia (AML), suggesting it might play an oncogenic role of AML. However, the during leukemogenesis remains to be elucidated. MiR-335/ID4 expression detected by real-time quantitative PCR and/or...
Previous study has revealed that H19 expression is required for efficient tumor growth induced by BCR-ABL in chronic myeloid leukemia (CML). Herein, we further determined and its clinical implication patients with CML. methylation were detected real-time quantitative PCR methylation-specific PCR, then of was analyzed. significantly up-regulated CML (p < 0.001). an area under receiver operating characteristic curve value 0.824 might serve as a promising biomarker distinguishing from controls....
Leukemia stem cell (LSC)-enriched genes have been shown to be highly prognostic in acute myeloid leukemia (AML). However, the value of tumor suppressor (TSGs) that are repressed early LSC remains largely unknown. We compared public available expression/methylation profiling data LSCs with hematopoietic cells (HSCs), order identify potential LSC. The relevance PCDH17 was analyzed on a cohort 173 AML patients from Cancer Genome Atlas (TCGA), and further validated three independent cohorts (n =...