A5100451612- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Biological and pharmacological studies of plants
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Ophthalmology and Eye Disorders
- Anesthesia and Pain Management
- GABA and Rice Research
- Retinal and Optic Conditions
- Diagnosis and Treatment of Venous Diseases
- CNS Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Colorectal and Anal Carcinomas
- Peripheral Artery Disease Management
- Esophageal Cancer Research and Treatment
- Cerebral Venous Sinus Thrombosis
- NF-κB Signaling Pathways
- Venous Thromboembolism Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Pituitary Gland Disorders and Treatments
Qiqihar Medical University
2025
Army Medical University
2025
Southwest Hospital
2025
Sun Yat-sen University Cancer Center
2025
Sun Yat-sen University
2013-2024
Henan University of Science and Technology
2024
Sichuan Cancer Hospital
2002-2023
University of Electronic Science and Technology of China
2017-2023
Northeast Forestry University
2021-2023
Second Hospital of Anhui Medical University
2019-2023
Inflammasome activation plays key roles in host defense, but also contributes to the pathogenesis of auto-inflammatory, and neurodegenerative diseases. As autophagy is connected with both innate adaptive immune systems, autophagic dysfunction closely related inflammation, infection, neurodegeneration. Here we identify that lincRNA-Cox2, previously known as a mediator repression genes expression cells, could bind NF-κB p65 promote its nuclear translocation transcription, modulating...
The Cancer Genome Atlas Project (TCGA) is a National Institute effort to profile at least 500 cases of 20 different tumor types using genomic platforms and make these data, both raw processed, available all researchers. TCGA data are currently over 1.2 Petabyte in size include whole genome sequence (WGS), exome sequence, methylation, RNA expression, proteomic, clinical datasets. Publicly accessible released through public portals, but many challenges exist navigating obtained from sites. We...
Alzheimer's disease (AD) is the most common type of age-related neurodegenerative disorder; nevertheless, nowadays there are no reliable biomarkers or non-invasive techniques available for its early detection. Recent studies have indicated that circulating level profiles microRNAs (miRNAs) h ave potential to be used as valuable diagnosis, staging, and progress monitoring various diseases. Here we report a novel 9-miRNA signature (hsa-miR-26a-5p, hsa-miR-181c-3p, hsa-miR-126-5p,...
Small cell lung cancer (SCLC) accounts for nearly 15% of human cancers and is one the most aggressive solid tumors. The SCLC cells are thought to derive from self-renewing pulmonary neuroendocrine by oncogenic transformation. However, whether possess stemness plasticity differentiation as normal stem has not been well understood thus far. In this study, we investigated expressions multilineage markers in line (NCI-H446) analyzed their clonogenicity, tumorigenicity, inducing differentiation....
Extranodal natural killer/T-cell lymphoma (ENKTL), nasal-type, is a distinct subtype of non-Hodgkin lymphoma. ENKTL sensitive to radiotherapy, but the prognosis poorer than those other types early stage To date, optimal treatment strategies for patients with have not been fully defined.We retrospectively investigated efficacy and safety pegaspargase, gemcitabine, oxaliplatin (P-GEMOX) combined different dose radiotherapy (RT) in 35 newly diagnosed, IE IIE at our institution from October 2011...
Abstract Background The clinical correlates, prognosis and determinants of acute kidney injury (AKI) in patients with coronavirus disease 2019 (Covid-19) remain largely unclear. Methods We retrospectively reviewed medical records all adult laboratory-confirmed Covid-19 who were admitted to the intensive care unit (ICU) between January 23rd 2020 April 6th at Wuhan JinYinTan Hospital First Affiliated Guangzhou Medical University. Results Among 210 patients, 131 males (62.4%). median Age was 64...
Abstract Background Tumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding diversity in retinoblastoma (RB), the primary intraocular malignancy children, remains limited. Methods The landscape of RB was constructed based on single-cell transcriptomic sequencing from 11 and 5 retina samples. Various analyses were conducted, including assessing overall activity, correlation between hypoxia pathways. Additionally, expression pattern monocarboxylate...
Uncoupling protein 2 (UCP2) is essential for maintaining redox homeostasis and regulating energy metabolism. Abnormal expression of UCP2 has been associated with various tumors, including leukemia. Genipin (GEN), a specific inhibitor UCP2, long history use in traditional Chinese medicine. However, the precise role underlying mechanisms inhibition leukemia cells by GEN remain inadequately understood. This study focuses on levels myeloid (ML) investigates effects proliferation, mitochondrial...
Rationale: Myogenesis is a strictly regulated process driven by signaling pathways activating muscle-specific gene expression. During myogenesis, muscle stem cells exhibit DNA damage response (DDR) features, which are essential for myoblast differentiation and skeletal regeneration. However, the specific roles of DDR-associated proteins in these processes not yet fully understood. Methods: Gene knockdown knockout were used cell animal models to study RNF138's function Multi-omics profiling,...
Background: Altered expression of the BCL-2 family member MCL-1 has been linked to progression and outcome various malignancies. Recently, inhibitor S63845 was reported kill MCL-1-dependent cancer cells potential value in clinical application. Purpose: Herein, we pattern Chinese de novo acute myeloid leukemia (AML) its impact on prognosis may provide theoretical basis for AML patients using clinics. Real-time quantitative PCR carried out detect transcript patients. Results:MCL-1...
MircoRNA-335 (miR-335) has been reported as a significant cancer-associated microRNA, which was often epigenetically silenced and acted tumor suppressor gene in diverse human solid tumors. Conversely, recent studies show that miR-335 overexpression identified both adult pediatric acute myeloid leukemia (AML), suggesting it might play an oncogenic role of AML. However, the during leukemogenesis remains to be elucidated. MiR-335/ID4 expression detected by real-time quantitative PCR and/or...
Previous studies have been indicated that integrin α2 (ITGA2) may be important in cell migration, invasion, survival, and angiogenesis. However, the correlation between ITGA2 expression acute myeloid leukemia (AML) is still unclear. Real‐time quantitative polymerase chain reaction was carried out to analyze messenger RNA level. Methylation‐specific (PCR) bisulfite sequencing PCR were performed detect methylation of promoter. significantly upregulated 134 de novo AML patients compared with 33...
Acute myeloid leukemia (AML) is a highly heterogenous hematological malignancy and its prognostication depends on the genetic mutation expression profile of each patient. Pantothenate kinase (PANK) regulatory enzyme that controls coenzyme A (CoA) biosynthesis. It has four isoforms encoded by PANK1-4, respectively. Whether PANK family prognostic significance in AML remains unclear.We screened The Cancer Genome Atlas database for patients with complete PANK1-4 data. Eighty-four met criteria...
Previous studies demonstrated that inflammatory microenvironment promoted prostate cancer progression. This study investigated whether total glucosides of paeony (TGP), the active constituents extracted from root Paeonia Lactiflora Pall, suppressed lipopolysaccharide (LPS)-stimulated proliferation, migration and invasion in androgen insensitive cells. PC-3 cells were incubated with LPS (2.0 μg/mL) absence or presence TGP (312.5 μg /mL). As expected, at S phase nuclear CyclinD1, markers cell...
BACKGROUND:Renal fibrosis occurs in the end-stage of all chronic kidney disease. Transforming growth factor-β1 (TGF-β1) is a central contributor fibrosis. Identifying effective biomarkers that targets TGF-β1 necessary for development therapeutic agents In this study, we investigated effects and mechanism long non-coding RNA (LncRNA)-ATB induced human 2 (HK-2) cells. MATERIAL AND METHODS:We either overexpression or knockdown LncRNA-ATB on inflammation, cell apoptosis, senescence HK-2 cells...