A5060389661- Gut microbiota and health
- Probiotics and Fermented Foods
- Bone Metabolism and Diseases
- Parasitic Infections and Diagnostics
- Viral gastroenteritis research and epidemiology
- Animal Nutrition and Physiology
- Clostridium difficile and Clostridium perfringens research
- Animal Disease Management and Epidemiology
- Trace Elements in Health
- Helminth infection and control
- Osteoarthritis Treatment and Mechanisms
- Connective tissue disorders research
- Herpesvirus Infections and Treatments
- Peroxisome Proliferator-Activated Receptors
- Parasites and Host Interactions
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Viral Infections and Vectors
- Ruminant Nutrition and Digestive Physiology
- Parasite Biology and Host Interactions
- Toxoplasma gondii Research Studies
- Animal Virus Infections Studies
- TGF-β signaling in diseases
- High Altitude and Hypoxia
Huazhong Agricultural University
2016-2025
Tibet University
2016-2025
University of Science and Technology of China
2011-2025
Jilin Agricultural University
2025
Zhejiang Chinese Medical University
2025
Army Medical University
2025
Southwest Hospital
2025
Henan Agricultural University
2022-2025
Chinese PLA General Hospital
2025
CAS Key Laboratory of Urban Pollutant Conversion
2025
Ulcerative colitis (UC) is a chronic and progressive inflammatory gastrointestinal disease closely associated with gut microbiota dysbiosis metabolic homeostasis disruption. Although targeted microbial therapies are an emerging intervention strategy for bowel (IBD), the mechanisms by which specific probiotics, such as Lactobacillus fermentum 016 (LF), alleviate UC remain unclear. The current study evaluated effects of LF supplementation on health in basal model using C57BL/6 mice....
Poly(vinyl alcohol) (PVA) hydrogel nanoparticles have been prepared by using a water-in-oil emulsion technology plus cyclic freezing-thawing process. The PVA this method are suitable for protein/peptide drug delivery since formation of the does not require crosslinking agents or other adjuvants and involve any residual monomer. Particularly, there is no emulsifier involved in new method. Bovine serum albumin (BSA), as model protein drug, incorporated into nanoparticles. possess skewed...
Yaks living in the high-altitude hypoxic environment of Tibetan plateau (3600 m) have special gut microbes. However, it is still little research on yak probiotics until now. Therefore, purpose our study was to evaluate growth promoting effect, antioxidant capability, immune and anti-inflammatory ability Bacillus subtilis velezensis isolated from yaks mice model. The results showed that strains supplementation not only improve performance but also increased length villus small intestine...
The purpose of this study was to evaluate the antibacterial activity and safety bacterias with probiotic potential isolated from free-ranging Tibetan yaks in high altitude regions Tibet. For purpose, one Leuconostoc pseudomesenteroides strain (named P1) two Lactobacillus johnsonii mucosae strains LY1 LY2), respectively, were fecal samples yaks. isolates studied using Escherichia coli (E. ATCC 25922), Staphylococcus aureus (S. 26112), Salmonella enteritidis NCTC 13349) as indicator pathogens....
Abstract Background Colonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed ameliorative effect milk replacer administration gut microbial development early-weaned ruminants. Yimeng black goats (YBGs) inhabiting Shandong, China show a complex ecosystem, but studies their are still insufficient report. Here, this study was performed investigate how develops weaned YBGs with age replacer....
Industrial production, ore smelting and sewage disposal plant can discharge large amounts of heavy metals every year, which may contaminate soil, water air, posing a great threat to ecological environment animal production. Hexavalent chromium [Cr (VI)], recognized metallic contaminant, has been shown impair kidney, liver gastrointestinal tract many species, but little is known about the gut microbial characteristics chickens exposed Cr (VI). Herein, this study characterized alternations...
The continuous spread of highly pathogenic avian influenza virus (AIV) subtype H5N1 is threatening the poultry industry and human health worldwide. Rapid sensitive diagnostic methods are required for surveillance. In this study, fluorescent (FL) probe CdTe quantum dots (QDs) was designed using covalently linked rabbit anti-AIV antibody. Based on these QD-antibody conjugates, a novel sandwich FL-linked immunosorbent assay (sFLISA) developed viral antigen detection. sFLISA allowed...
Abstract Background Tibial dyschondroplasia (TD) is a common skeletal disorder in broiler chickens. It characterized by the presence of non-vascularized and unmineralized cartilage growth plate. Previous studies have investigated differential expression genes related to development during latter stages TD. The aim our study was identify differentially expressed (DEGs) plate chickens, which were associated with early stage We induced TD using tetramethylthiuram disulfide (thiram) for 1, 2, 6...
Tibial dyschondroplasia (TD) is an important long bone defect of broiler chickens that disturbs the proximal growth plate and characterized by non-vascularized cartilage, a distended lameness. Celastrol, medicinal root extract from plant Tripterygium wilfordii, reported widely as well-known heat-shock protein 90 (Hsp90) inhibitor. Recently, Hsp90 inhibition in chondrocyte differentiation growth-plate vascularization were effective restoring morphology plate. The present study was aimed at...
Tibial dyschondroplasia (TD) is an abnormality of the growth cartilage that occurs in chickens and other rapidly growing avian species. This disease not only cause huge economic losses, but also greatly affects animal welfare. The total flavonoids Rhizoma drynariae (TFRD) has been used to cure wide variety diseases including bone fractures osteoarthritis osteoporosis. However, less information available about using TFRD against TD. aim this study was determine effect on TD by regulating...
Tibial dyschondroplasia (TD) is an intractable poultry problem that characterized by the appearance of non-vascularized and non-mineralized cartilage masses in tibial growth plates (TGPs). However, role angiogenesis inhibition occurrence TD remains unknown. In this study, we found that, compared to low-altitude Arbor Acres chickens (AACs), high-altitude Tibetan showed higher vascular distributions were accompanied up-regulation hypoxia-inducible factor-1α (HIF-1α), endothelial factor A...
Abstract Tibial dyschondroplasia (TD) is the most-prevalent leg disorder in fast-growing chickens; it intractable and characterized by abnormal endochondral bone formation of proximal tibial growth-plates (TGPs). Previous studies have shown that a highly vascularized tissue dependent on coordinated coupling between angiogenesis osteogenesis, but underlying mechanisms remodeling are poorly defined TD chickens. Here, we observed inhibition vasculogenesis remarkably impaired vascular invasion...
Abstract Background The gut microbiota is a complex ecosystem, which essential for the metabolism, health and immunity of host. Many diseases have been shown to be closely related alteration intestinal flora. Aeromonas veronii as conditioned pathogen can cause disease in Yangtze finless porpoise through infections. However, it not clear whether caused by changes In current study, diversity composition healthy -infected were evaluated high-throughput sequencing further investigate potential...
Gut microbiota has been demonstrated to be associated with multiple gastrointestinal diseases, but information regarding the gut microbial alternations in diarrheic giraffe remains scarce. Here, 16S rDNA and ITS gene amplicon sequencing were conducted investigate composition variability giraffes. Results that Firmicutes Proteobacteria most dominant phyla bacterial community, whereas Ascomycota Basidiomycota observed predominant fungal community regardless of health status. However, species...