A5078408795- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Acute Kidney Injury Research
- T-cell and B-cell Immunology
- HIV Research and Treatment
- S100 Proteins and Annexins
- Respiratory Support and Mechanisms
- Virus-based gene therapy research
- Neonatal and Maternal Infections
- Advanced battery technologies research
- Advanced Battery Technologies Research
- Immunotherapy and Immune Responses
- Congenital Diaphragmatic Hernia Studies
- Inflammation biomarkers and pathways
- Electrocatalysts for Energy Conversion
- Infant Nutrition and Health
- Pneumonia and Respiratory Infections
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Immune Response and Inflammation
- Mechanical Circulatory Support Devices
- Microbial infections and disease research
Shanghai Children's Hospital
2013-2024
Shanghai Jiao Tong University
2013-2024
Guangzhou Automobile Group (China)
2024
Xinyang College of Agriculture and Forestry
2019-2024
ZTE (China)
2024
Hebei General Hospital
2015-2024
Union Hospital
2024
Hunan University
2023
Changji University
2023
Donghua University
2023
Increased albuminuria is associated with obesity and diabetes a risk factor for cardiovascular renal disease. However, the link between early adiposity remains unclear. To determine whether adiponectin, an adipocyte-derived hormone, communication signal adipocytes kidney, we performed studies in cohort of patients at high kidney disease as well adiponectin-knockout (Ad–/–) mice. Albuminuria had negative correlation plasma adiponectin obese patients, Ad–/– mice exhibited increased fusion...
As a prerequisite for clinical application, we determined the long-term therapeutic effectiveness and safety of adeno-associated virus (AAV)-S100A1 gene therapy in preclinical large animal model heart failure. S100A1, positive inotropic regulator myocardial contractility, becomes depleted failing cardiomyocytes humans animals, myocardial-targeted S100A1 transfer rescues cardiac contractile function by restoring sarcoplasmic reticulum calcium (Ca(2+)) handling acutely chronically hearts small...
Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein-coupled receptors (GPCRs) protects myocardium in ischemia/reperfusion injury (I/R) models. GPCR signaling pathways are regulated (GRKs), GRK2 has been shown to be a critical molecule normal pathological cardiac function.A loss activity is known arrest progression heart failure (HF), at least part normalization β-adrenergic receptor (βAR) signaling. Chronic HF studies have performed with...
OBJECTIVES: To determine the diagnostic and clinical utility of trio-rapid genome sequencing in critically ill infants. DESIGN: In this prospective study, samples from infants were analyzed using both proband-only exome (proband biological parents). The study occurred between April 2019 December 2019. SETTING: Thirteen member hospitals China Neonatal Genomes Project spanning 10 provinces involved. PARTICIPANTS: Critically ( n = 202), birth up until 13 months life enrolled based on...
Hydrogen is a renewable energy source with various features, clean, carbon-free, high density, which being recognized internationally as “future energy.” The US, the EU, Japan, South Korea, China, and other countries or regions are gradually clarifying development position of hydrogen. rapid hydrogen industry requires more hydrogenation infrastructure to meet need fuel cell vehicles. Nevertheless, due frequent occurrence accidents, their safety has become an obstacle large-scale...
Tibial dyschondroplasia (TD) is an intractable poultry problem that characterized by the appearance of non-vascularized and non-mineralized cartilage masses in tibial growth plates (TGPs). However, role angiogenesis inhibition occurrence TD remains unknown. In this study, we found that, compared to low-altitude Arbor Acres chickens (AACs), high-altitude Tibetan showed higher vascular distributions were accompanied up-regulation hypoxia-inducible factor-1α (HIF-1α), endothelial factor A...
Abstract Tibial dyschondroplasia (TD) is the most-prevalent leg disorder in fast-growing chickens; it intractable and characterized by abnormal endochondral bone formation of proximal tibial growth-plates (TGPs). Previous studies have shown that a highly vascularized tissue dependent on coordinated coupling between angiogenesis osteogenesis, but underlying mechanisms remodeling are poorly defined TD chickens. Here, we observed inhibition vasculogenesis remarkably impaired vascular invasion...
Double-layer pipelines are widely used in deep-sea energy transport because of their strong thermal insulation and enhanced structural safety. The stress distribution the interaction mechanism between inter-pipes double-layer elucidated. A mechanical model is developed to characterize deformation difference two layers. response pipeline can be divided into distinct modes based on initial stages: (1) an inner-pipe-dominated elongation that creates compressive inner pipe tensile outer pipe,...
Neonates are at high risk of meningitis and resulting neurologic complications. Early recognition neonates poor prognosis would be helpful in providing timely management. From January 2008 to June 2014, we enrolled 232 term with bacterial admitted 3 neonatology departments Shanghai, China. The clinical status on the day discharge from these hospitals or a postnatal age 2.5 months was evaluated using Glasgow Outcome Scale (GOS). Patients were classified into two outcome groups: good (167...
Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease characterized by impaired pulmonary alveolar development in preterm infants. Until now, little known about the molecular and cellular basis of BPD. There increasing evidence that lncRNAs regulate cell proliferation apoptosis during organogenesis. The potential role pathogenesis BPD unclear. This study aims to clarify MALAT1 process infants illustrate protective effect involved infants.We assessed expression mice tissues...
The G(βγ)-sequestering peptide β-adrenergic receptor kinase (βARK)ct derived from the G-protein-coupled (GRK)2 carboxyl terminus has emerged as a promising target for gene-based heart failure therapy. Enhanced downstream cAMP signaling been proposed underlying mechanism increased (βAR) responsiveness. However, molecular targets mediating improved cardiac contractile performance by βARKct and its impact on G(βγ)-mediated have yet to be fully elucidated.
Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons the efficacy these inhibitors carried out. Moreover, most studies not examined whether are able induce survival advantage that results in an expansion genetically-modified cells following infection. We evaluated three leading replication: 1) HIV-1 tat/rev-specific small hairpin (sh) RNA; 2) RNA antisense gene specific for envelope; and 3) viral entry inhibitor, maC46. In stably...
Background: Candida species is an important cause of nosocomial infection in neonatal intensive care units (NICUs). However, most reports China have been limited to single institutions. The aim this study investigate the epidemiology invasive candidiasis multiple NICUs across China. Methods: We retrospectively collected demographic data, clinical characteristics, microbiological results and outcome preterm infants with discharged from 11 academic tertiary during January 2009 December 2011....
Tibial dyschondroplasia (TD) is one of the most common problems in poultry industry and leads to lameness by affecting proximal growth plate tibia. However, due unique environmental geographical conditions Tibet, no case TD has been reported Tibetan chickens (TBCs). The present study was designed investigate effect high altitude hypoxia on blood parameters tibial development using complete count, morphology, histological examination. results this showed an undesirable impact overall...
The diagnosis of neonatal invasive fungal disease (IFD) is difficult and often delayed. platelet parameters (1, 3)-β-D-Glucan (BG) may be useful for diagnosing IFD, but their diagnostic performance are not well characterized in neonates. We studied 63 preterm infants with 160 without sepsis (preterm control), 41 bacterial sepsis. Platelet at the first day onset IFD fourteenth after antifungal treatment were evaluated. Serum BG was measured. count (PC), plateletcrit (PCT), distribution width...