A5026568367- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Ion channel regulation and function
- Advanced Fluorescence Microscopy Techniques
- Sleep and Wakefulness Research
- stochastic dynamics and bifurcation
- Cardiac electrophysiology and arrhythmias
- Advanced Memory and Neural Computing
- Muscle Physiology and Disorders
- Gene Regulatory Network Analysis
- Muscle activation and electromyography studies
- Cardiomyopathy and Myosin Studies
- Neuroscience and Neural Engineering
- Force Microscopy Techniques and Applications
- Cell Image Analysis Techniques
- Complex Systems and Time Series Analysis
- Neurobiology and Insect Physiology Research
- Blind Source Separation Techniques
- Advanced MRI Techniques and Applications
- Nonlinear Dynamics and Pattern Formation
- Exercise and Physiological Responses
- thermodynamics and calorimetric analyses
- Mitochondrial Function and Pathology
- Molecular Communication and Nanonetworks
UNSW Sydney
2020-2025
University of Lübeck
2023
University Hospital Schleswig-Holstein
2023
Kiel University
2023
Goethe University Frankfurt
2011-2020
University Hospital Frankfurt
2010-2020
Heidelberg University
2006-2019
Imaging Center
2012
Klinik und Poliklinik für Neurologie
2010-2012
Czech Academy of Sciences, Institute of Physiology
2011
This study identifies by microautoradiography activated microglia/macrophages as the main cell type expressing peripheral benzodiazepine binding site (PBBS) at sites of active CNS pathology. Quantitative measurements PBBS expression in vivo obtained PET and [11C](R)-PK11195 are shown to correspond animal experimental human post-mortem data on distribution pattern microglia inflammatory brain disease. Film autoradiography with [3H](R)-PK11195, a specific ligand for PBBS, showed minimal normal...
Neural oscillations subserve many human perceptual and cognitive operations. Accordingly, brain functional connectivity is not static in time, but fluctuates dynamically following the synchronization desynchronization of neural populations. This dynamic has recently been demonstrated spontaneous fluctuations Blood Oxygen Level-Dependent (BOLD) signal, measured with Magnetic Resonance Imaging (fMRI). We analyzed temporal BOLD their electrophysiological correlates, by means long (approx. 50...
The integration of segregated brain functional modules is a prerequisite for conscious awareness during wakeful rest. Here, we test the hypothesis that temporal integration, measured as long-term memory in history neural activity, another important quality underlying awareness. For this aim, study blood oxygen level-dependent signals across human nonrapid eye movement sleep cycle. Results reveal property gradually decreases from wakefulness to deep and such affect areas identified with...
In ventricular cardiac myocytes, T-tubule density is an important determinant of the synchrony sarcoplasmic reticulum (SR) Ca2+ release and could be involved in reduced SR ischemic cardiomyopathy. We therefore investigated properties pigs, 6 weeks after inducing severe stenosis circumflex coronary artery (91+/-3%, N=13) with myocardial infarction (8.8+/-2.0% total left mass). Severe dysfunction infarct adjacent myocardium was documented by magnetic resonance Doppler velocity imaging....
This review focuses on recent development in artificial synaptic devices, including working principles, device structures, processing techniques, energy consumption, the functional materials of synapses and applications.
We analyze statistical and information-theoretical properties of EEG microstate sequences, as seen through the lens five different clustering algorithms. Microstate sequences are computed for $n=20$ resting state recordings during wakeful rest. The input all algorithms is set topographic maps obtained at local maxima spatial variance. This data processed by two classical (1) atomize agglomerate hierarchical (AAHC) (2) a modified K-means algorithm, well (3) K-medoids, (4) principal component...
We use second harmonic generation (SHG) imaging to study and quantify a strong intrinsic SHG signal in skeletal muscle fiber preparations single isolated myofibrils. The follows the striation pattern of cells is positioned at sarcomeric location myosin filaments. Interestingly, enhanced region where heads are located on As reflects subcellular structure an accurate way, can be used for noninvasive high resolution structural without exogenous labels living cells. This may very important...
Store-operated Ca(2+) entry (SOCE) is an important mechanism in virtually all cells. In adult skeletal muscle, this highly specialized for the rapid delivery of from transverse tubule into junctional cleft during periods depleting release. dystrophic muscle fibers, SOCE may be a source overload, leading to cell necrosis. However, possibility yet examined fiber To examine this, tubular system and cytoplasm were simultaneously imaged direct release sarcoplasmic reticulum (SR) fibers healthy...
Higher-order syntax properties of EEG microstate sequences offer insight into the transition dynamics functional brain networks. We here define higher-order as sequence that are not explained by first-order matrix, and we postulate three requirements surrogate data should fulfill to provide a null hypothesis for tests. then compare two general approaches generation have been used in research, (a) surrogates from Markov chain model, and, (b) obtained shuffling. There different ways...
Background In dystrophic skeletal muscle, osmotic stimuli somehow relieve inhibitory control of dihydropyridine receptors (DHPR) on spontaneous sarcoplasmic reticulum elementary Ca2+ release events (ECRE) in high external environments. Such ‘uncontrolled’ sparks were suggested to act as signals. They may be related mechanosensitive pathways but the mechanisms are elusive. Also, it is not known whether truncated dystrophins can correct disinhibition. Methodology/Principal Findings We recorded...
Spatio-temporal patterns in electroencephalography (EEG) can be described by microstate analysis, a discrete approximation of the continuous electric field produced cerebral cortex. Resting-state EEG microstates are largely determined alpha frequencies (8-12 Hz) and we recently demonstrated that occur periodically with twice frequency. To understand origin periodicity, analyzed analytic amplitude phase resting-state oscillations independently. In data found rotating organized around small...
Abstract Purpose: Selective delivery of drugs into the target tissue is expected to result in high drug concentrations interest and therefore enhanced efficacy. To develop a peptide-based radiopharmaceutical, we investigated properties peptide with affinity for human breast cancer, which has been selected through phage display. Experimental Design: The bioactivity p160 (VPWMEPAYQRFL) was evaluated vitro vivo. specific binding cancer MDA-MB-435 cells confirmed competition experiments....
Ajmaline is a widely used antiarrhythmic drug. Its action on voltage-gated ion channels in skeletal muscle not well documented and we have here elucidated its effects Na(+) K(+) channels.Sodium (I(Na)) potassium (I(K)) currents amphibian fibres were recorded using 'loose-patch' two-microelectrode voltage clamp techniques (2-MVC). Action potentials generated current clamp.Under 'loose patch' conditions, the IC(50) for I(Na) was 23.2 microM with Hill-coefficient h=1.21. For I(K), 9.2 microM,...
The G(βγ)-sequestering peptide β-adrenergic receptor kinase (βARK)ct derived from the G-protein-coupled (GRK)2 carboxyl terminus has emerged as a promising target for gene-based heart failure therapy. Enhanced downstream cAMP signaling been proposed underlying mechanism increased (βAR) responsiveness. However, molecular targets mediating improved cardiac contractile performance by βARKct and its impact on G(βγ)-mediated have yet to be fully elucidated.