A5101807110- Extracellular vesicles in disease
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- RNA modifications and cancer
- Folate and B Vitamins Research
- Electrospun Nanofibers in Biomedical Applications
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Connective tissue disorders research
- Cardiac Ischemia and Reperfusion
- Advanced biosensing and bioanalysis techniques
- Congenital heart defects research
- Histone Deacetylase Inhibitors Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA and protein synthesis mechanisms
- Glutathione Transferases and Polymorphisms
- IL-33, ST2, and ILC Pathways
- MXene and MAX Phase Materials
Soochow University
2014-2025
Zhengzhou University
2025
First Affiliated Hospital of Soochow University
2015-2023
Shanghai Children's Hospital
2017-2021
Shanghai Jiao Tong University
2017-2021
National Cheng Kung University
2005
Background Exosomes are membranous vesicles generated by almost all cells. Recent studies demonstrated that mesenchymal stem cell–derived exosomes possessed many effects, including antiapoptosis, anti‐inflammatory stimulation of angiogenesis, anticardiac remodeling, and recovery cardiac function on cardiovascular diseases. However, targeting to recipient cells precisely in vivo still remains a problem. Ligand fragments or homing peptides discovered phage display biopanning methods fused the...
Background . To cure ischemic diseases, angiogenesis needs to be improved by various strategies in area. Considering that microRNA-132 (miR-132) regulates endothelial cell behavior during and the safe efficacious delivery of microRNAs vivo is rarely achieved, an ideal vehicle for miR-132 could bring promise diseases. As a natural carrier biological molecules, exosomes are more developed as miRNA transfer. Meanwhile, mesenchymal stem cells release large amounts exosomes. Thus, this study...
Our study aim was to evaluate the therapeutic efficacy and mechanisms of miR-133-overexpressing mesenchymal stem cells (MSCs) on acute myocardial infarction. Rat MSCs were isolated purified by whole bone marrow adherent culturing. After transfection with agomir or antagomir miR-133, collected for assay cell vitality, apoptosis, cycle progression. At same time, exosomes from supernatant analyze paracrine miR-133. For in-vivo studies, constitutive activation miR-133 in achieved...
Abstract Exosomes derived from human umbilical cord mesenchymal stem cells (UMSC‐Exos) have shown encouraging effects in regulating inflammation and attenuating myocardial injury. Macrophages are regulated dynamically response to environmental cues. However, the underlying mechanisms by which UMSC‐Exos regulate macrophage polarization still not well understood. Herein, it is aimed explore of on their roles cardiac repair after infarction (MI). These results show that improve function...
Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease characterized by impaired pulmonary alveolar development in preterm infants. Until now, little known about the molecular and cellular basis of BPD. There increasing evidence that lncRNAs regulate cell proliferation apoptosis during organogenesis. The potential role pathogenesis BPD unclear. This study aims to clarify MALAT1 process infants illustrate protective effect involved infants.We assessed expression mice tissues...
Nanoparticle-mediated drug delivery has emerged as a highly promising and effective therapeutic approach for addressing myocardial infarction. However, clinical translation tends to be failure due low cardiac retention well liver spleen entrapment in previous therapies. Herein, we report two-step exosome system, which precludes internalization by the mononuclear phagocyte system before of targeting exosomes (ExoCTP). Importantly, curcumin released ExoCTP diminishes reactive oxygen species...
Abstract Background Interleukin 33 is known to have an important influence in the process of myocardial infarction, and immunoregulatory function MSCs could be influenced by cell factors. In this study, we evaluated therapeutic efficacy IL-33-overexpressing bone marrow mesenchymal stem cells (IL33-MSCs) on infarction (MI) detected inflammatory level cardiac rats. Methods results First, proliferation T polarization macrophages that had been co-cultured with Vector-MSCs or IL33-MSCs....
It is still unclear whether the timing of intracoronary stem cell therapy affects therapeutic response in patients with myocardial infarction. The natural course healing infarction and presence putative homing signals within damaged myocardium appear to favor engraftment during transendothelial passage early days after reperfusion. However, adverse inflammatory environment, its high oxidative stress, might be deleterious if cells are administered too Here we highlight several aspects...
Recent studies indicate important roles for SMAD4 in SMCs proliferation, extracellular matrix maintenance, and blood vessel remodeling. However, the genetic effects of pathogenesis thoracic aortic aneurysm dissection (TAAD) are still largely unknown. Here we identified a functional variant which might be involved pathological progression TAAD. Five tagging SNPs were genotyped 202 TAAD cases 400 controls using MALDI-TOF. rs12455792 CT or TT genotypes was associated with an significantly...
Metastasis-associated gene 1(MTA1) has been identified as an oncogene in many tumors, and aberrant MTA1 expression linked to carcinogenesis metastasis. We aim investigate the mechanism of metastasis malignant pleural mesothelioma (MPM).Real-time polymerase chain reaction (PCR) immunohistochemical staining were employed detect E-cadherin MPM tissues corresponding adjacent tissues. Stable clone with knock-down was generated shRNA via lentivirus technology cell lines. Wound-healing assay,...
The length of hospital stay (LOS) is crucial for assessing medical service quality. This study aimed to develop machine learning models predicting risk factors prolonged LOS in patients with aortic dissection (AD). data 516 AD were obtained from the hospital's system, 111 (> 30 days) group based on three quarters entire cohort. Given screened variables and prediction models, XGBoost model demonstrated superior predictive performance identifying LOS, due highest area under receiver operating...
Thoracic aortic aneurysm and dissection (TAAD) is the most fatal macro vascular disease. The mortality of 48h after diagnosis up to approximately 50-68%. However, genetic factors potential mechanism underlying sporadic TAAD remain largely unknown. Our previous study suggested rs12455792 variant SMAD4 gene significantly contributed increased risk might participated pathological progression TAAD. This investigation aims test (1) associations between MØ recruitment, inflammatory response in...
Dysregulation of glutathione-S-transferase M3 (GSTM3) has been related to clear cell renal carcinoma (ccRCC) in our former study. GSTM3 plays a pivotal role detoxification and clearance reactive oxygen species (ROS) tumour tissues. This study aimed examine: (1) the associations between single nucleotide polymorphisms (SNPs) risk ccRCC, (2) potential molecular mechanism accounting for its effects. 5 SNPs 3'UTR were initially genotyped 329 cases 420 healthy controls. A SNP-rs1055259 was found...
Bone marrow-derived mesenchymal stem cells (MSCs) have shown great promise in tissue engineering and regenerative medicine; however, the capacity of senescent MSCs is greatly reduced, thus exhibiting limited therapy potential. Previous studies uncovered that microRNA-206 (miR-206) could largely regulate cell functions, including proliferation, survival, apoptosis, but whether miR-206 involved process remains unknown. In this study, we mainly elucidated effects on MSC senescence underlying...
Myocardial infarction is a leading cause of mortality worldwide. Angiogenesis in the infarct border zone vital for heart function restoration after myocardial infarction. Hypoxia-induced MSC modification safe and effective approach angiogenesis clinical therapy; however, mechanism still requires further investigation. In our study, we preconditioned human umbilical cord mesenchymal stem cells (huMSCs) with hypoxia isolated small extracellular vesicles (sEVs) to promote cardiac repair. We...
Abstract Background- Exosomes derived from human umbilical cord mesenchymal stem cells (UMSCs-Exo) were recommended as ideal substitutes for cell-free cardiac regenerative medicine, which had presented encouraging effects in regulating inflammation and attenuating myocardial injury. The phenotype of macrophages resident myocardium regulated dynamically response to environmental cues, may either protect against injury or promote maladaptive remodeling. However, the underlying mechanisms about...
Thoracic aortic dissection is a devastating cardiovascular disease with an increasing annual incidence. The homozygous mutation in rs1801133 site has been accepted for decreased enzyme activity of mutant MTHFR protein, contributing to accumulated homocysteine blood. Recently, elevated level causally associated increased risk disease. Conversely, the relationship between and thoracic poorly understood. Here, generated human induced pluripotent stem cell (iPSC) line provided novel strategy...
Abstract Background: SARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to human health and causes long-term burden on cardiovascular system. Individuals with pre-existing diseases are at higher risk for SARS-CoV-2 infection tend have worse prognosis. However, relevance pathogenic mechanisms between COVID-19 not yet completely comprehended. Methods: Common differentially expressed genes (DEGs) were obtained in datasets induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)...