A5007067864- Nanoplatforms for cancer theranostics
- Metal Alloys Wear and Properties
- Microstructure and Mechanical Properties of Steels
- Bone Metabolism and Diseases
- Bone health and treatments
- Smart Grid Energy Management
- Energy Load and Power Forecasting
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Electric Power System Optimization
- High Temperature Alloys and Creep
- Bone Tissue Engineering Materials
- Temporomandibular Joint Disorders
- Photoacoustic and Ultrasonic Imaging
- Advanced materials and composites
- Metallurgy and Material Forming
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Sirtuins and Resveratrol in Medicine
- Orthodontics and Dentofacial Orthopedics
- Extracellular vesicles in disease
Sichuan University
2016-2025
Maine Medical Center
2020-2025
Maine Medical Center Research Institute
2020-2025
Gansu Agricultural University
2023-2025
Stomatology Hospital
2021-2025
Northwest A&F University
2023-2025
Jinhua Academy of Agricultural Sciences
2025
State Key Laboratory of Oral Diseases
2017-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Soochow University
2018-2024
Background Exosomes are membranous vesicles generated by almost all cells. Recent studies demonstrated that mesenchymal stem cell–derived exosomes possessed many effects, including antiapoptosis, anti‐inflammatory stimulation of angiogenesis, anticardiac remodeling, and recovery cardiac function on cardiovascular diseases. However, targeting to recipient cells precisely in vivo still remains a problem. Ligand fragments or homing peptides discovered phage display biopanning methods fused the...
Abstract Fenton reaction–based chemodynamic therapy (CDT) has attracted considerable attention for tumor treatment, because the reaction can degrade endogenous H 2 O within to form reactive oxygen species (ROS) kill cancer cells. The kinetics of significantly influenced its treatment efficacy. It is crucial enhance at maximum concentration quickly produce vast amounts ROS achieve efficacy, which date, not been realized. Herein, reported an efficacious CDT breast using biomimetic CS‐GOD@CM...
Microglia as an important type of innate immune cell in the brain have been considered effective therapeutic target for treatment central nervous degenerative diseases. Herein, we report membrane coated novel biomimetic Cu2–xSe-PVP-Qe nanoparticles (denoted CSPQ@CM nanoparticles, where PVP is poly(vinylpyrrolidone), Qe quercetin, and CM neuron cells) effectively targeting modulating microglia to treat Parkinson's disease (PD). The CSPQ exhibit multienzyme activities could scavenge reactive...
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies a major component fibrillar alpha-synuclein (α-syn). Herein, boosting PD therapeutic efficacy by enhancing the autophagy microglia to phagocytose and degrade α-syn via controlled opening their surface TRPV1 channels rationally designed photothermal nanoagent reported. The Cu2-x Se-anti-TRPV1 nanoparticles (CS-AT NPs) are fabricated target open under second near infrared (NIR-II) laser irradiation cause influx Ca2+...
Glioblastoma (GBM), as a very aggressive cancer of central nervous system, is challenging to completely cure by the conventional combination surgical resection with radiotherapy and chemotherapy. The success emerging immunotherapy in hot tumors has attracted considerable interest for treatment GBM, but unique tumor immunosuppressive microenvironment (TIME) GBM leads failure immunotherapy. Here, we show significant improvement efficacy modulating TIME through novel all-in-one biomimetic...
Abstract Mitochondrial dysfunction of neurons is the core pathogenesis incurable Parkinson's disease (PD). It crucial to ameliorate mitochondrial for boosting therapy PD. Herein, remarkable promotion biogenesis and improve treatment PD by using mitochondria‐targeted biomimetic nanoparticles, which are Cu 2‐ x Se‐based nanoparticles functionalized with curcumin wrapped DSPE‐PEG 2000 ‐TPP‐modified macrophage membrane (denoted as CSCCT NPs), reported. These can efficiently target mitochondria...
Herein we synthesize DOX-loaded ultra-small Cu<sub>2−x</sub>Se nanoparticles for the NIR-II photodynamic therapy and chemotherapy of orthotopic malignant glioblastoma.
The small difference between tumor and normal tissues in their responses to ionizing radiation has been a significant issue for radiotherapy of tumors. Herein, we report that dumbbell-shaped heterogeneous copper selenide-gold nanocrystals can serve as an efficient radiosensitizer enhanced radiotherapy. mean lethal dose X-rays 4T1 cells be drastically decreased about 40%, is, decreasing from 1.81 1.10 Gy after culture with heterostructures. Due the synergetic effect heterostructures, is also...
Breast cancer remains to show high mortality and poor prognosis in women despite of significant progress recent diagnosis treatment. Herein, we report the rational design a highly efficient ultrasmall nanotheranostic agent with excellent photodynamic therapy (PDT) performance against breast its metastasis by eliciting antitumor immunity. The nanoagent (3.1 ± 0.4 nm) was fabricated from polyethylene glycol modified Cu2- xSe nanoparticles, β-cyclodextrin, chlorin e6 under ambient conditions....
Abstract Recent studies have demonstrated the stimulatory effects of adiponectin on bone formation, but mechanism underlying these remains unclear. The Wnt/β-catenin pathway, one most important pathways in osteogenesis, has rarely been associated with osteogenic previous studies. present study was designed to investigate mesenchymal stem cell (BMSC) differentiation and formation through pathway. We detected receptor expression BMSCs, constructed a recombinant adenovirus containing human...
Abstract T cell dysfunction‐induced tumor immune escape is particularly severe in glioblastoma (GBM), and significantly affects the efficacy of immunotherapy. It crucial to innovatively reverse dysfunction for improving GBM Herein, remarkably reversed immunotherapy boosted by repurposing U. S. Food Drug Administration‐approved antidepressant paroxetine (PX) with biomimetic nanoparticles (CS‐J@CM/6 NPs). The PX successfully applied abrogate sequestration bone marrow GBM‐bearing mice increase...
Delayed bone-healing of senile osteoporotic fractures remains a clinical challenge due to the alterations caused by aging in bone and immune systems. The novel biomaterials that address deficiencies both skeletal cells systems are required effectively treat injuries older patients. Zinc (Zn) has shown promise as biodegradable material for use orthopedic implants. To elderly patients with injuries, we developed Zn-based alloy (Zn–2Cu-0.5Zr) enhanced mechanical properties, including yield...
Radiotherapy has been extensively used to treat cancer patients because it can effectively damage most solid tumors without penetration limits. A hypoxic microenvironment in leads severe radioresistance and expression of inducible factor-1 (HIF-1), which results poor efficacy radiotherapy alone. Herein, we report the excellent achieved using a new type yolk–shell Cu2–xSe@PtSe (CSP) nanosensitizer functionalized with HIF-1α inhibitor acriflavine (ACF). We prepare CSP through interfacial redox...
Long lasting persistent luminescence nanoparticles with the highest quantum yield were successfully prepared by a one-step hydrothermal method for bioimaging.