A5100764898- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Trace Elements in Health
- Monoclonal and Polyclonal Antibodies Research
- Research in Cotton Cultivation
- Autophagy in Disease and Therapy
- S100 Proteins and Annexins
- Ubiquitin and proteasome pathways
- Congenital Heart Disease Studies
- Circular RNAs in diseases
- Heat shock proteins research
- Enzyme-mediated dye degradation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Heavy Metal Exposure and Toxicity
- Soil erosion and sediment transport
- Advanced biosensing and bioanalysis techniques
- Galectins and Cancer Biology
- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Pyrroles
- Radiomics and Machine Learning in Medical Imaging
- Multicomponent Synthesis of Heterocycles
- Phytochemistry and Biological Activities
China Medical University
2016-2025
Taizhou People's Hospital
2025
Nantong University
2025
Henan University of Technology
2023-2025
Nanjing Medical University
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Northwest A&F University
2015-2024
Qingdao University
2019-2024
Gansu University of Traditional Chinese Medicine
2017-2024
Union Hospital
2021-2024
Plasmonics has drawn significant attention in the area of biosensors for decades due to unique optical properties plasmonic resonant nanostructures. While sensitivity and specificity molecular detection relies significantly on resonance conditions, been dedicated design, fabrication, optimization substrates. The adequate choice materials, structures, functionality goes hand with a fundamental understanding plasmonics enable development practical that can be deployed real life situations....
Abstract Recently, cardiac telocytes were found in the myocardium. However, functional role of and possible changes telocyte population during myocardial infarction myocardium are not known. In this study, recently identified ( MI ) was investigated. Cardiac distributed longitudinally within cross network myocardium, which impaired . zone undetectable from approximately 4 days to weeks after an experimental coronary occlusion used induce Although non‐ischaemic area ischaemic heart...
Yaks living in the high-altitude hypoxic environment of Tibetan plateau (3600 m) have special gut microbes. However, it is still little research on yak probiotics until now. Therefore, purpose our study was to evaluate growth promoting effect, antioxidant capability, immune and anti-inflammatory ability Bacillus subtilis velezensis isolated from yaks mice model. The results showed that strains supplementation not only improve performance but also increased length villus small intestine...
The NaFNFSI-based SPE can deliver the excellent interfacial stability with Na metal and good cycling performances for Na|SPE|NaCu<sub>1/9</sub>Ni<sub>2/9</sub>Fe<sub>1/3</sub>Mn<sub>1/3</sub>O<sub>2</sub> cell.
Engineering of fungal laccases with optimum catalytic activity at alkaline pH has been a long-lasting challenge. In this study, mutant library containing 3000 clones was obtained by error-prone PCR to adapt the laccase Lcc9 from basidiomycete Coprinopsis cinerea. After three rounds functional screening, amino acid changes (E116K, N229D, I393T) named PIE5 selected. showed an 8.5 and 8.0 against guaiacol 2,6-DMP when expressed in Pichia pastoris, representing first that possesses condition....
Aberrantly upregulated choline phospholipid metabolism is a novel emerging hallmark of cancer, and kinase α (CHKα), key enzyme for phosphatidylcholine production, overexpressed in many types human cancer through undefined mechanisms. Here, we demonstrate that the expression levels glycolytic enolase-1 (ENO1) are positively correlated with CHKα glioblastoma specimens ENO1 tightly governs via posttranslational regulation. Mechanistically, reveal both ubiquitin E3 ligase TRIM25 associated CHKα....
Aims: The aim of the present study is to investigate differential expression CD44, CD47 and c-met in ovarian clear cell carcinoma (OCCC), correlation their relationship with biological behavior OCCC. Methods: We used immunohistochemistry examine OCCC (86 cases) investigated effects interaction these molecules on development Results: was significantly high Expression CD44 correlated patient surgical stage, chemotherapy resistance prognosis (all p < 0.05), but did not correlate lymph node...
Abstract We developed an inexpensive, portable platform for urea detection via electrochemistry by depositing silver nanoparticles (AgNPs) on a commercial glucose test strip. modified this strip first removing the enzymes from surface, followed electrodeposition of AgNPs one channel (working electrode). The morphology was characterized Scanning Electron Microscopy (SEM), and its electrochemical performance evaluated Cyclic Voltammetry (CV) Electrochemical Impedance Spectroscopy (EIS). device...
For more effective early-stage cancer diagnostics, there is a need to develop sensitive and specific, non- or minimally invasive, cost-effective methods for identifying circulating nanoscale extracellular vesicles (EVs). Here, we report the utilization of simple plasmonic scaffold composed microscale biosilicate substrate embedded with silver nanoparticles surface-enhanced Raman scattering (SERS) analysis ovarian endometrial EVs. These substrates are rapidly inexpensively produced without...
Ovarian cancer is one of the most common malignant tumors female reproductive system, which seriously threatens health patients. It great significance to identify biomarkers improve clinical status ovarian patients.Methylation, RNA- sequencing, Copy number variation (CNV), mutation and characteristics control samples were downloaded from The Cancer Genome Atlas database (TCGA). "iClusterPlus". R package was used cluster molecular subtypes. copy entire lncRNA genome analyzed using GISTIC....
Type 2 diabetes (T2D) is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by combined static magnetic field (SMF) electric field. We systematically compared four types of SMFs found downward SMF ∼100 mT could effectively reduce the development hyperglycemia, fatty liver, weight gain, tissue injury in high-fat-diet (HFD)/streptozocin-induced T2D mice, but not upward SMF. The markedly restored Bacteroidetes population reversed...
PAK1 plays an important role in proliferation and tumorigenesis, at least partially by promoting ERK phosphorylation of C-RAF (Ser-338) or MEK1 (Ser-298). We observed how that overexpression a kinase-dead mutant form increased MEK1/2 (Ser-217/Ser-221) (Thr-202/Tyr-204), although B-RAF (Ser-445) remained unchanged. Furthermore, activation the activator Rac1 induced formation triple complex Rac1, PAK1, independent kinase activity PAK1. These data suggest can stimulate MEK kinase-independent...
Beclin 1 is an autophagy-associated protein involved in apoptosis and drug resistance, as well various malignancies. We investigated the expression of ovarian epithelial tissues correlated it with prognosis cancer. was determined using immunohistochemistry 148 patients cancer, 26 borderline tumor, 25 benign 30 normal tissue. The relationships between cancer pathological characteristics were analyzed. risk factors for analyzed Cox’s regression model. A survival curve plotted from follow-up...
An efficient and straightforward preparation of cyanoindolizine derivatives <italic>via</italic> a cycloaddition reaction between 1-cyanocyclopropane 1-ester pyridine or benzopyridine.